Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(12), P. 1571 - 1571
Published: Dec. 9, 2024
Microneedles
(MNs),
composed
of
multiple
micron-scale
needle-like
structures
attached
to
a
base,
offer
minimally
invasive
approach
for
transdermal
drug
delivery
by
penetrating
the
stratum
corneum
and
delivering
therapeutic
agents
directly
epidermis
or
dermis.
Hydrogel
microneedles
(HMNs)
stand
out
among
various
MN
types
due
their
excellent
biocompatibility,
high
drug-loading
capacity,
tunable
drug-release
properties.
This
review
systematically
examines
matrix
materials
fabrication
methods
HMN
systems,
highlighting
advancements
in
natural
synthetic
polymers,
explores
applications
treating
conditions
such
as
wound
healing,
hair
loss,
cardiovascular
diseases,
cancer.
Furthermore,
potential
HMNs
disease
diagnostics
is
discussed.
The
identifies
key
challenges,
including
limited
mechanical
strength,
efficiency,
lack
standardization,
while
proposing
strategies
overcome
these
issues.
With
integration
intelligent
design
enhanced
control
over
dosage
safety,
are
poised
revolutionize
expand
personalized
medicine.
Gels,
Journal Year:
2025,
Volume and Issue:
11(3), P. 206 - 206
Published: March 15, 2025
Hydrogel
microneedles
(HMNs)
have
emerged
as
a
transformative
platform
for
minimally
invasive
drug
delivery
and
biosensing,
offering
enhanced
bioavailability,
controlled
release,
real-time
biomarker
detection.
By
leveraging
swelling
hydrogels,
nanomaterial
integration,
stimuli-responsive
properties,
HMNs
provide
precision
medicine
capabilities
across
diverse
therapeutic
diagnostic
applications.
However,
challenges
remain
in
mechanical
stability,
hydrogel-based
MNs
must
balance
flexibility
with
sufficient
strength
skin
penetration.
Drug
retention
release
require
optimization
to
prevent
premature
diffusion
ensure
sustained
effects.
Additionally,
biosensing
accuracy
is
influenced
by
variability
interstitial
fluid
extraction
signal
transduction.
Clinical
translation
hindered
regulatory
hurdles,
scalability
concerns,
the
need
extensive
safety
validation
human
trials.
This
review
critically
examines
key
materials,
fabrication
techniques,
functional
testing
frameworks
of
while
addressing
these
limitations.
Furthermore,
we
explore
future
research
directions
smart
wearable
MNs,
AI-assisted
hybrid
drug–device
platforms
optimize
transdermal
medicine.
Overcoming
barriers
will
drive
clinical
adoption
HMNs,
paving
way
next-generation
patient-centered
therapeutics
diagnostics.
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
15
Published: April 17, 2025
Melanoma
is
highly
invasive
and
resistant
to
conventional
treatments,
accounting
for
nearly
75%
of
skin
cancer-related
deaths
globally.
Traditional
therapies,
such
as
chemotherapy
immunotherapy,
often
exhibit
limited
efficacy
are
associated
with
significant
side
effects
due
systemic
drug
exposure.
Microneedles
(MNs),
an
emerging
delivery
system,
offer
multiple
advantages,
including
safety,
painlessness,
minimal
invasiveness,
controlled
release.
Among
these,
hydrogel
microneedles
(HMNs)
stand
out
their
extracellular
matrix-like
structure
swelling-induced
continuous
channels,
which
enable
the
direct
therapeutic
agents
into
tumor
microenvironment
(TME).
This
approach
enhances
bioavailability
while
reducing
toxicity,
establishing
HMNs
a
promising
platform
melanoma
treatment.
review
highlights
recent
advancements
in
therapy,
focusing
on
applications
biomarker
extraction
early
diagnosis
role
supporting
multimodal
treatment
strategies,
chemotherapy,
phototherapy,
targeted
combination
therapy.
Furthermore,
current
matrix
materials
fabrication
techniques
discussed.
Finally,
limitations
critically
analyzed,
recommendations
future
research
development
provided.
World Journal of Diabetes,
Journal Year:
2025,
Volume and Issue:
16(5)
Published: April 24, 2025
Diabetic
wounds
represent
a
significant
challenge
in
the
medical
field,
significantly
impacting
patient
quality
of
life
and
imposing
heavy
burden
on
healthcare
systems.
Intelligent
hydrogel
dressings
have
attracted
attention
diabetic
wound
treatment
due
to
their
unique
properties.
This
review
systematically
explores
three
main
categories
intelligent
hydrogels
(natural,
synthetic,
composite),
dissecting
composition,
structure,
mechanisms
that
enable
responses.
The
crucial
roles
these
maintaining
moist
environment,
efficiently
absorbing
exudate,
precisely
delivering
drugs
are
expounded.
Moreover,
application
advantages
combating
bacteria
infections,
regulating
inflammation
immunity,
promoting
angiogenesis
tissue
regeneration,
as
well
enabling
real-time
monitoring
personalized
treatment,
explored
depth.
Additionally,
we
discuss
future
research
directions
prospects
for
precision
medicine
care,
aiming
inspire
innovation
provide
comprehensive
theoretical
basis
development
next-generation
dressings.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
30, P. 101432 - 101432
Published: Dec. 28, 2024
Flap
techniques
are
indispensable
in
modern
surgery
because
of
their
role
repairing
tissue
defects
and
restoring
function.
Ischemia-reperfusion
oxidative
stress-induced
injuries
the
main
causes
flap
failure.
Oxidative
stress
exacerbates
cell
damage
through
accumulation
reactive
oxygen
species
(ROS),
thereby
affecting
function
survival.
Effective
management
these
factors
is
essential
for
improving
survival
post-operative
recovery.
In
this
study,
we
utilized
hollow
mesoporous
cerium
dioxide
nanoparticles
loaded
with
quercetin,
which
were
later
into
a
light-cured
double
cross-linked
hydrogel
(HQu@BC)
injected
site
to
activate
macrophage
reprogramming
maintain
local
ROS
homeostasis
reduce
inflammation.
Quercetin
scavenges
reduces
mitochondrial
due
its
intrinsic
reducing
structures
such
as
catechols,
carbon-carbon
bonds,
hydroxyl
synergistic
nanoparticles,
inhibits
inflammation
by
suppressing
M1
polarization.
This
system
continuously
regulates
levels,
kills
bacteria
ultimately
inflammation,
creating
favorable
microenvironment
innovative
injectable
composite
nanoparticle
material
has
anti-inflammatory,
antioxidant,
antimicrobial,
healing-promoting
properties,
providing
new
approach
success
surgery.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(8)
Published: Feb. 1, 2025
Abstract
Chronic
wounds,
as
a
kind
of
long‐term
disease
that
is
difficult
to
cure,
are
challenged
in
healthcare,
placing
substantial
physical,
emotional,
and
economic
burdens
on
patients
society.
Effective
treatment
chronic
wounds
essential
for
improving
patient
quality
life,
reducing
healthcare
costs,
alleviating
the
strain
medical
resources.
Hydrogel
materials
have
emerged
promising
candidates
wound
due
their
exceptional
adaptability
environments
ability
deliver
various
therapeutic
agents,
effectively
promoting
healing
wounds.
However,
wide
array
available
with
diverse
functionalities
presents
challenge
selecting
most
appropriate
components
synthesizing
hydrogel
dressings.
This
review
summarizes
common
materials,
including
properties,
cross‐linking
methods,
applications.
Additionally,
it
systematically
categorizes
different
elucidating
action
mechanisms
effects.
Furthermore,
this
work
offers
guidance
material
selection
dressing
design
based
characteristics
Finally,
challenges
future
perspectives
composite
hydrogels
field
dressings
discussed.
provides
readers
comprehensive
understanding
reliable
basis
synthesize
ideal
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 6, 2025
Diabetic
wound
healing
remains
a
significant
clinical
challenge
because
of
hyperglycaemia-induced
cellular
senescence,
impaired
angiogenesis,
and
chronic
inflammation.
To
address
these
issues,
we
developed
multifunctional
hydrogel
(GelMA/PNS/Alg@IGF-1)
that
integrates
gelatine
methacryloyl
(GelMA),
Panax
notoginseng
saponins
(PNS),
sodium
alginate
microspheres
encapsulating
insulin-like
growth
factor-1
(IGF-1).
This
was
engineered
to
achieve
gradient
sustained
release
bioactive
agents
target
senescence
promote
vascular
repair.
In
vitro
studies
demonstrated
the
significantly
reduced
oxidative
stress,
suppressed
markers
senescence-associated
secretory
phenotypes,
restored
endothelial
cell
function
under
high-glucose
conditions
by
inhibiting
NF-κB
pathway
activation.
Transcriptomic
analysis
revealed
modulation
pathways
linked
inflammation,
apoptosis,
angiogenesis.
accelerated
diabetic
closure
in
rat
model
vivo
enhanced
collagen
deposition,
granulation
tissue
formation,
neovascularization.
Furthermore,
mitigated
stress
promoted
remodelling.
The
synergistic
effects
PNS
IGF-1
within
established
pro-regenerative
microenvironment
both
pathological
ageing
dysfunction.
These
findings
highlight
GelMA/PNS/Alg@IGF-1
as
promising
therapeutic
platform
for
management,
this
material
offers
dual
anti-senescence
proangiogenic
efficacy
overcome
complexities
healing.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Microneedle
patches
have
emerged
as
a
promising
approach
for
diabetic
wound
healing
by
enabling
the
targeted
delivery
of
therapeutic
agents
such
stem
cells
and
their
derived
exosomes,
well
localized
bioactive
moieties.
These
offer
non-invasive
efficient
method
administering
payloads
directly
to
site
wound,
bypassing
systemic
circulation
minimizing
potential
side
effects.
The
holds
immense
promoting
tissue
regeneration
accelerating
in
patients.
Similarly,
cell-derived
which
are
known
regenerative
anti-inflammatory
properties,
can
enhance
process.
Furthermore,
microneedle
enable
precise
controlled
release
moieties,
growth
factors
cytokines,
site,
creating
conducive
microenvironment
repair
regeneration.
challenges
associated
with
multifaceted.
Biocompatibility
issues,
variability
skin
characteristics
among
patients,
regulatory
hurdles,
scalability,
cost
considerations,
long-term
stability,
patient
acceptance
compliance
all
present
significant
barriers
widespread
adoption
optimization
technology
clinical
practice.
Overcoming
these
will
require
collaborative
efforts
from
various
stakeholders
advance
field
address
critical
gaps
research
development.
Ongoing
focuses
on
enhancing
biocompatibility
mechanical
properties
materials,
developing
customizable
technologies
personalized
treatment
approaches,
integrating
advanced
functionalities
sensors
real-time
monitoring,
improving
engagement
adherence
through
education
support
mechanisms.
advancements
improve
management
providing
tailored
therapies
that
promote
faster
reduce
complications.
This
review
explores
current
landscape
context
management,
highlighting
both
need
be
addressed
future
perspectives
this
innovative
modality.
