Mitochondria-Targeting Virus-Like Gold Nanoparticles Enhance Chemophototherapeutic Efficacy Against Pancreatic Cancer in a Xenograft Mouse Model DOI Creative Commons
Y Meng, Chuan Chen,

Ronggui Lin

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 14059 - 14074

Published: Dec. 1, 2024

Background:The dense and fibrotic nature of the pancreatic tumor microenvironment significantly contributes to invasion metastasis.This challenging environment acts as a formidable barrier, hindering effective drug penetration delivery, which ultimately limits efficacy conventional cancer treatments.Gold nanoparticles (AuNPs) have emerged promising nanocarriers overcome extracellular matrix barrier; however, their limited targeting precision, poor delivery efficiency, insufficient photothermal conversion present challenges.Methods: We developed triphenyl phosphonium-functionalized high-branch gold nanoparticles, denoted Dox@TPAu, enhance capabilities.The targeted penetration, biopharmaceutical pharmacokinetic properties Dox@TPAu were characterized, synergistic therapeutic effect was evaluated by BxPC-3 xenograft mouse model.Results: exhibits superior efficiency (91.0%) alongside high loading (26%) photo-triggered drug-release potential.This system adeptly accumulates at sites due its unique properties, enabling localization within cells mitochondria stromal fibroblasts.This disrupts mitochondrial function transfer-processes crucial for energy production, metabolism, cell signaling microenvironment.Pharmacokinetic analyses revealed an optimal spatiotemporal distribution site.This strategic accumulation enables precise disruption both physical barrier cells, enhancing treatment through near-infrared light-triggered local chemo-photothermal therapy.Conclusion: Our findings demonstrate that this innovative strategy effectively leverages mitochondriatargeting, virus-like AuNPs efficient depletion, presenting approach treatment.

Language: Английский

Silencing Ribosome biogenesis regulator 1 homolog (RRS1) inhibits angiogenesis and cisplatin resistance of lung cancer cells by activating ferroptosis mediated by p53 pathway DOI
Ling Lin, Ying Zou, Di Zhang

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 94, P. 102796 - 102796

Published: Feb. 14, 2025

Language: Английский

Citations

0
Progress in the application of molecular imaging technology in immunological tolerance and immune metabolism visualization research DOI Creative Commons
Kailang Li, Fang Xie, Yongfu Xiong

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

Immunological tolerance and immune metabolism play crucial roles in maintaining homeostasis the response to diseases. The advancement of molecular imaging technologies, particularly optical imaging, nuclear medicine magnetic resonance has led a significant progress visualization metabolism. Molecular technologies enable real-time monitoring analysis dynamic changes mechanisms living organisms, allowing development new strategies for early disease diagnosis, targeted therapy, immunotherapy. This article reviews latest advancements application fields immunological metabolism, with focus on their applications regulation regulation,

Language: Английский

Citations

0
Tumor-targeting Nanomaterials Based on Metal-organic Frameworks Mediate Tumor Immunotherapy by Promoting Cuproptosis and Pyroptosis in Hepatocellular Carcinoma Cells DOI Creative Commons

Xiaoyuan Yi,

Huaying Xie,

Kunzhao Huang

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101745 - 101745

Published: April 1, 2025

Language: Английский

Citations

0
Mitochondria-Targeting Virus-Like Gold Nanoparticles Enhance Chemophototherapeutic Efficacy Against Pancreatic Cancer in a Xenograft Mouse Model DOI Creative Commons
Y Meng, Chuan Chen,

Ronggui Lin

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 14059 - 14074

Published: Dec. 1, 2024

Background:The dense and fibrotic nature of the pancreatic tumor microenvironment significantly contributes to invasion metastasis.This challenging environment acts as a formidable barrier, hindering effective drug penetration delivery, which ultimately limits efficacy conventional cancer treatments.Gold nanoparticles (AuNPs) have emerged promising nanocarriers overcome extracellular matrix barrier; however, their limited targeting precision, poor delivery efficiency, insufficient photothermal conversion present challenges.Methods: We developed triphenyl phosphonium-functionalized high-branch gold nanoparticles, denoted Dox@TPAu, enhance capabilities.The targeted penetration, biopharmaceutical pharmacokinetic properties Dox@TPAu were characterized, synergistic therapeutic effect was evaluated by BxPC-3 xenograft mouse model.Results: exhibits superior efficiency (91.0%) alongside high loading (26%) photo-triggered drug-release potential.This system adeptly accumulates at sites due its unique properties, enabling localization within cells mitochondria stromal fibroblasts.This disrupts mitochondrial function transfer-processes crucial for energy production, metabolism, cell signaling microenvironment.Pharmacokinetic analyses revealed an optimal spatiotemporal distribution site.This strategic accumulation enables precise disruption both physical barrier cells, enhancing treatment through near-infrared light-triggered local chemo-photothermal therapy.Conclusion: Our findings demonstrate that this innovative strategy effectively leverages mitochondriatargeting, virus-like AuNPs efficient depletion, presenting approach treatment.

Language: Английский

Citations

0