Camouflaged Nanozymes with Oxidation‐Promoting Activities Triggering Ferroptosis for Radio‐Immunotherapy DOI Creative Commons
Kun Qiao, Yongbiao Huang, Shipeng Ning

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Abstract Radioresistance presents a substantial obstacle to achieving optimal therapeutic outcomes for breast cancer treatment. In this study, we develop cell membrane (CM) ‐ coated nanozyme system (MPPC@CM), specifically designed radioimmunotherapy address issue. This innovative involves the in situ reduction of platinum and palladium on mesoporous silica nanospheres, followed by functionalization with cinnamaldehyde via surface grafting. The CM coating endows enhanced tumor‐specific targeting capability due its homing properties. Upon uptake tumor cells, MPPC@CM catalytically generates O 2 from H , mitigating hypoxic microenvironment reducing radioresistance. intracellular glutathione depletion mediated Michael addition reactions concurrently disrupts endogenous antioxidant defenses against reactive oxygen species (ROS). redox imbalance is synergistically amplified through nanozyme‐mediated catalytic activities including both peroxidase‐like oxidase‐like functions. resultant massive ROS accumulation establishes self‐reinforcing oxidative cascade that ultimately induces functional inactivation peroxidase 4. immunosuppressive environment remodeled disturbance balance, which accelerates ferroptosis increases CD8 + T‐cell infiltration dendritic maturation. Overall, membrane‐camouflaged holds significant potential enhance efficacy radioimmunotherapy.

Language: Английский

Reprogramming Lung Redox Homeostasis by NIR Driven Ultra‐Small Pd Loaded Covalent Organic Framework Inhibits NF‐κB Pathway for Acute Lung Injury Immunotherapy DOI Creative Commons

Doudou Lei,

Lin Liao, Tao Qin

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Acute lung injury (ALI) refers to damage related cells, typically caused by an uncontrollable inflammatory response, and over‐generated reactive oxygen species (ROS). Increasing evidence suggests that reprogramming redox homeostasis holds significant potentials for the clinical treatment of ALI. Herein, simple synthesis ultra‐small Pd loaded covalent organic framework (COF) (TP@Pd) is reported, which, when combined with near infrared (NIR) irradiation, exhibits nanozyme functionalities, including multiple enzyme mimicking activities broad spectrum ROS scavenging, thereby promoting tissue repair ALI immunotherapy. Mechanistically, through therapeutic strategy TP@Pd+NIR, damaged cells tissues are ameliorated decreasing intracellular levels (total ROS, ·OH ·O 2 − ), downregulating cytokines (IL‐6, TNF‐α IL‐1β), upregulating antioxidant factor level (SOD2), inducing macrophage M2 directional polarization (downregulation iNOS CD86, upregulation IL‐10 CD206), activating immunoregulation (CD4 + /CD8 ratio increase), (upregulation HSP70 CD31), suppressing NF‐κB signaling pathway phosphorylated p65 IκBα). Furthermore, following intravenous (IV) injection in rats, TP@Pd accumulated 6 h, indicating promising efficacy via this administration route. Notably, TP@Pd+NIR demonstrated excellent synergistic effects alleviating inflammation storms, reducing diffuse alveolar damage, accelerating repair. Summarily, work has designed a novel enhancement amelioration, which may serve as approach other diseases.

Language: Английский

Citations

0
Wearable artificial kidney technology for toxin removal: The need, opportunities, and challenges in incorporating advanced materials DOI
Hanlin Yao, Xinyu You,

Refate Yushan

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161659 - 161659

Published: March 1, 2025

Language: Английский

Citations

0
Camouflaged Nanozymes with Oxidation‐Promoting Activities Triggering Ferroptosis for Radio‐Immunotherapy DOI Creative Commons
Kun Qiao, Yongbiao Huang, Shipeng Ning

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Abstract Radioresistance presents a substantial obstacle to achieving optimal therapeutic outcomes for breast cancer treatment. In this study, we develop cell membrane (CM) ‐ coated nanozyme system (MPPC@CM), specifically designed radioimmunotherapy address issue. This innovative involves the in situ reduction of platinum and palladium on mesoporous silica nanospheres, followed by functionalization with cinnamaldehyde via surface grafting. The CM coating endows enhanced tumor‐specific targeting capability due its homing properties. Upon uptake tumor cells, MPPC@CM catalytically generates O 2 from H , mitigating hypoxic microenvironment reducing radioresistance. intracellular glutathione depletion mediated Michael addition reactions concurrently disrupts endogenous antioxidant defenses against reactive oxygen species (ROS). redox imbalance is synergistically amplified through nanozyme‐mediated catalytic activities including both peroxidase‐like oxidase‐like functions. resultant massive ROS accumulation establishes self‐reinforcing oxidative cascade that ultimately induces functional inactivation peroxidase 4. immunosuppressive environment remodeled disturbance balance, which accelerates ferroptosis increases CD8 + T‐cell infiltration dendritic maturation. Overall, membrane‐camouflaged holds significant potential enhance efficacy radioimmunotherapy.

Language: Английский

Citations

0