Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(5)
Published: April 9, 2025
ABSTRACT
In
this
study,
we
have
synthesized
imidazo[1,2‐a]
pyridine
derivatives
with
NO
(
EA
02
)
and
NH
2
03
functional
groups.
These
groups
the
advantage
of
providing
sites
for
future
branching
to
stabilize
molecule
in
chosen
target
environment.
The
results
obtained
from
our
theoretical
analyses
(density
theory,
molecular
orbital
analysis,
electrostatic
potential
Mulliken
dynamics
simulations)
ADMET
(absorption,
distribution,
metabolism,
excretion
toxicity)
score
show
that
are
comparable
lapatinib
(4‐anilino‐quinazoline),
an
inhibitor
intracellular
tyrosine
kinase
domains
epidermal
growth
factor
receptor
(EGFR).
What
is
more,
meet
all
Lipinski,
Muegge,
Egan,
Veber
Ghose
rules
drug
similarity.
