Photocurable Dual‐Network Hydrogels Based on Natural Polymers for Sutureless Repair of Large Corneal Defects DOI Open Access
Qing Li,

Ruyin Zhang,

Chengpei Ouyang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract Corneal transplantation remains the prevailing treatment for corneal defects, which is always restricted by donor shortages and numerous postoperative complications accompanying suturing. Photocurable hydrogels have emerged as alternative therapeutic strategies repair of but most focus on repairing focal defects still suffer from low transparency poor mechanical properties. Herein, photocurable hydrogel GelMA/OCS composed gelatin methacryloyl (GelMA) oxidized chondroitin sulfate (OCS) developed sutureless large (6 mm). This injectable hybridized demonstrates excellent transparency, swelling rate, enhanced properties, superior adhesion In vitro experiments reveal that can support proliferation migration, growth human epithelial cells (HCECs), demonstrating satisfactory cytocompatibility cell affinity. addition, capable accurately filling in rabbits forming grafts with smooth surfaces. Postoperative slit lamp, histological evaluation, transcriptomic analysis significantly facilitate re‐epithelialization integration reconstruction stromal structures, well reduce inflammation responses scar formation. Therefore, may provide a promising defects.

Language: Английский

Photocurable Dual‐Network Hydrogels Based on Natural Polymers for Sutureless Repair of Large Corneal Defects DOI Open Access
Qing Li,

Ruyin Zhang,

Chengpei Ouyang

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract Corneal transplantation remains the prevailing treatment for corneal defects, which is always restricted by donor shortages and numerous postoperative complications accompanying suturing. Photocurable hydrogels have emerged as alternative therapeutic strategies repair of but most focus on repairing focal defects still suffer from low transparency poor mechanical properties. Herein, photocurable hydrogel GelMA/OCS composed gelatin methacryloyl (GelMA) oxidized chondroitin sulfate (OCS) developed sutureless large (6 mm). This injectable hybridized demonstrates excellent transparency, swelling rate, enhanced properties, superior adhesion In vitro experiments reveal that can support proliferation migration, growth human epithelial cells (HCECs), demonstrating satisfactory cytocompatibility cell affinity. addition, capable accurately filling in rabbits forming grafts with smooth surfaces. Postoperative slit lamp, histological evaluation, transcriptomic analysis significantly facilitate re‐epithelialization integration reconstruction stromal structures, well reduce inflammation responses scar formation. Therefore, may provide a promising defects.

Language: Английский

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