A Multifunctional Electrochemical Biosensor Based on Near-Infrared Light-Responsive Hydrogel for In Vivo Recording and Modulation DOI
Congyu Zhang, Qi Zheng, Cui Li

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: June 3, 2025

Monitoring and regulating neural signals are crucial for the management of neurological disorders. Herein, we constructed a near-infrared light (NIR)-responsive device controllable recording modulation based on enzyme-loaded microgels/multiwalled carbon nanotubes (MWCNTs) composite-modified microelectrodes. The embedded MWCNTs within composites can convert NIR into heat via photothermal effect. Consequently, one hand, enzyme-catalyzed reactions electrode surface be reversibly modulated by light. Under irradiation, contraction temperature-responsive microgels not only facilitates direct bioelectrocatalysis but also promotes enzyme cascade catalysis surface. proposed method determine glucose concentrations ranging from 0.3 to 6.0 mM with detection limit 0.098 mM. Taking advantage superior antifouling ability biocompatibility, this was applied monitoring in vivo excellent stability up 2 h. On other implanted enabled activation TRPV1 channels, which further promoted autophagy microglia degradation alpha-synuclein mouse brain Parkinson's disease. We believe system, high spatiotemporal controllability, multifunctionality, has great prospects diagnostics therapeutics neurodegenerative diseases.

Language: Английский

Recent Trends in Molecularly Imprinted Photoelectrochemical Sensors DOI
Kheibar Dashtian,

Forough Zahedpour,

Amin Foroozandeh

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118271 - 118271

Published: April 1, 2025

Language: Английский

Citations

1
Preparation and Application of Enzyme-based Hydrogels DOI Creative Commons
Y. R. Wen, Xinghai Wang,

Jinxue Zhao

et al.

Biosensors and Bioelectronics X, Journal Year: 2025, Volume and Issue: unknown, P. 100594 - 100594

Published: Feb. 1, 2025

Language: Английский

Citations

0
Engineered Intelligent Electrochemical Biosensors for Portable Point-of-Care Diagnostics DOI Creative Commons

Jiamin Lin,

Yuanyuan Chen, Xiaohui Liu

et al.

Chemosensors, Journal Year: 2025, Volume and Issue: 13(4), P. 146 - 146

Published: April 16, 2025

The development of cost-effective, rapid-response, and user-friendly biosensing platforms has become paramount importance for achieving precise biomarker quantification in early disease detection. Implementing timely diagnostic interventions through accurate analysis not only significantly improves treatment outcomes but also enables effective management strategies, ultimately leading to substantial reductions patient mortality rates. These clinical imperatives have consequently driven the innovation portable point-of-care (POC) systems. Electrochemical biosensors are attractive diagnosis diseases due their low cost, simple operation, high sensitivity. This review examines prevalent material innovations electrode functionalization electrochemical platforms, with specific emphasis on translational applications early-stage included three important types: proteins, nucleic acids, small molecule metabolites. Furthermore, work proposes novel research trajectories next-generation biosensor development, advocating synergistic integration artificial intelligence-driven analytics, Internet Medical Things (IoMT)-enabled networks, advanced micro/nanofabrication techniques.

Language: Английский

Citations

0
A Multifunctional Electrochemical Biosensor Based on Near-Infrared Light-Responsive Hydrogel for In Vivo Recording and Modulation DOI
Congyu Zhang, Qi Zheng, Cui Li

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: June 3, 2025

Monitoring and regulating neural signals are crucial for the management of neurological disorders. Herein, we constructed a near-infrared light (NIR)-responsive device controllable recording modulation based on enzyme-loaded microgels/multiwalled carbon nanotubes (MWCNTs) composite-modified microelectrodes. The embedded MWCNTs within composites can convert NIR into heat via photothermal effect. Consequently, one hand, enzyme-catalyzed reactions electrode surface be reversibly modulated by light. Under irradiation, contraction temperature-responsive microgels not only facilitates direct bioelectrocatalysis but also promotes enzyme cascade catalysis surface. proposed method determine glucose concentrations ranging from 0.3 to 6.0 mM with detection limit 0.098 mM. Taking advantage superior antifouling ability biocompatibility, this was applied monitoring in vivo excellent stability up 2 h. On other implanted enabled activation TRPV1 channels, which further promoted autophagy microglia degradation alpha-synuclein mouse brain Parkinson's disease. We believe system, high spatiotemporal controllability, multifunctionality, has great prospects diagnostics therapeutics neurodegenerative diseases.

Language: Английский

Citations

0