Copper-coordination Driven Nano-frameworks for Efficient Colorectal Cancer Chemo-immunotherapy by Suppression of Cancer Cell Stemness DOI Creative Commons

Yi‐Chun Huang,

Hailong Tian,

Zongliang Yue

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101707 - 101707

Published: March 1, 2025

Cancer stemness, characterized by the self-renewal and differentiation capabilities of cancer stem cells (CSCs), is a critical determinant colorectal (CRC) chemo-immunotherapy. Herein, we repurposed copper-coordination driven metal-organic nano-frameworks (Cu-MOFs) to address chemo-immunotherapy resistance posed stemness. These Cu-MOFs were loaded with chemotherapeutic agent cisplatin (CDDP), resulting in formation Cu-MOF@CDDP. The Cu-MOF@CDDP are efficiently internalized CRC via nanoparticle mediated endocytosis, where they release free copper ions (Cu2+) CDDP high-glutathione (GSH) environment. After that, forms DNA-CDDP adducts that inhibit DNA synthesis repair, while Cu2+ induces cuproptosis disrupting mitochondrial metabolism. Moreover, fragments originating from both nucleus mitochondria activate cGAS-STING pathway, thereby initiating anti-tumor immune responses. Meanwhile, depletes intracellular GSH cuproptosis, leading downregulation stemness-related proteins such as ZEB1 c-MYC, which enhances efficacy targeting pathways involved maintaining Consequently, our results underscore substantial promise overcoming stemness-driven therapeutic resistance, offering transformative approach sensitize

Language: Английский

Immunomodulating Platelet-mimicking Nanoparticles for AIE-based Enhanced Photodynamic Immunotherapy against Lung Cancer DOI Creative Commons
Yuan Zhang,

Zhiji Wang,

Jia Wang

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101683 - 101683

Published: March 1, 2025

Language: Английский

Citations

0
Copper-coordination Driven Nano-frameworks for Efficient Colorectal Cancer Chemo-immunotherapy by Suppression of Cancer Cell Stemness DOI Creative Commons

Yi‐Chun Huang,

Hailong Tian,

Zongliang Yue

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101707 - 101707

Published: March 1, 2025

Cancer stemness, characterized by the self-renewal and differentiation capabilities of cancer stem cells (CSCs), is a critical determinant colorectal (CRC) chemo-immunotherapy. Herein, we repurposed copper-coordination driven metal-organic nano-frameworks (Cu-MOFs) to address chemo-immunotherapy resistance posed stemness. These Cu-MOFs were loaded with chemotherapeutic agent cisplatin (CDDP), resulting in formation Cu-MOF@CDDP. The Cu-MOF@CDDP are efficiently internalized CRC via nanoparticle mediated endocytosis, where they release free copper ions (Cu2+) CDDP high-glutathione (GSH) environment. After that, forms DNA-CDDP adducts that inhibit DNA synthesis repair, while Cu2+ induces cuproptosis disrupting mitochondrial metabolism. Moreover, fragments originating from both nucleus mitochondria activate cGAS-STING pathway, thereby initiating anti-tumor immune responses. Meanwhile, depletes intracellular GSH cuproptosis, leading downregulation stemness-related proteins such as ZEB1 c-MYC, which enhances efficacy targeting pathways involved maintaining Consequently, our results underscore substantial promise overcoming stemness-driven therapeutic resistance, offering transformative approach sensitize

Language: Английский

Citations

0