β-Cyclodextrin Encapsulated Platinum(II)-Based Nanoparticles: Photodynamic Therapy and Inhibition of the NF-κB Signaling Pathway in Glioblastoma DOI

Sakira Tabassum Borah,

Anushka Mondal, Bishnu Das

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

This study explores cell death through photodynamic therapy (PDT) with β-cyclodextrin-encapsulated platinum(II)-based nanoparticles (Pt-NPs) and the effect on NF-κB stress pathways in glioblastoma. The encapsulation of cyclometalated Pt(II) complex Pt(LL') within β-cyclodextrin (β-CD) enhances its biocompatibility, improves cellular penetration, boosts emission, thereby increasing effectiveness PDT. Both Pt-NPs show minimal toxicity dark; however, significantly increase toward glioblastoma Kr158 cells upon irradiation at 390 nm. PDT-induced is further validated apoptosis assays modulation some key survival like NF-κB/p65, DJ-1, ERp29. first report designed to target PDT, offering a promising strategy for enhancing therapeutic efficacy.

Language: Английский

β-Cyclodextrin Encapsulated Platinum(II)-Based Nanoparticles: Photodynamic Therapy and Inhibition of the NF-κB Signaling Pathway in Glioblastoma DOI

Sakira Tabassum Borah,

Anushka Mondal, Bishnu Das

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

This study explores cell death through photodynamic therapy (PDT) with β-cyclodextrin-encapsulated platinum(II)-based nanoparticles (Pt-NPs) and the effect on NF-κB stress pathways in glioblastoma. The encapsulation of cyclometalated Pt(II) complex Pt(LL') within β-cyclodextrin (β-CD) enhances its biocompatibility, improves cellular penetration, boosts emission, thereby increasing effectiveness PDT. Both Pt-NPs show minimal toxicity dark; however, significantly increase toward glioblastoma Kr158 cells upon irradiation at 390 nm. PDT-induced is further validated apoptosis assays modulation some key survival like NF-κB/p65, DJ-1, ERp29. first report designed to target PDT, offering a promising strategy for enhancing therapeutic efficacy.

Language: Английский

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