ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(47), P. 32578 - 32588
Published: Nov. 15, 2024
Gene
therapy
has
emerged
as
a
promising
approach
to
address
challenging
cardiovascular
diseases.
Extensive
efforts
have
been
focused
on
developing
highly
efficient
gene
vectors
with
precise
delivery
techniques
enhance
its
effectiveness.
In
this
study,
we
present
multifunctional
dopamine-gelatin
microneedle
patches
capabilities
achieve
perivascular
for
intimal
hyperplasia
treatment.
These
that
were
fabricated
through
freeze-drying
of
gelatin
are
recombinant
adeno-associated
virus
(rAAVs)-carrying
tips
and
dopamine
coating
backing
layers.
The
lyophilized
could
not
only
effectively
preserve
the
therapeutic
activity
rAAVs
but
also
demonstrate
capability
penetrate
adventitia
delivery.
incorporation
facilitated
patch
adhesion
extended
release
duration.
Based
these
advantages,
demonstrated
rAAVs-loaded
(AMNPs)
behave
satisfactorily
in
inhibit
carotid
artery
restenosis
rats.
features
indicate
AMNPs
clinically
valuable
treatment
vascular
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(23)
Published: March 14, 2023
Abstract
Microneedles
provide
an
effective
strategy
for
transdermal
drug
delivery.
Many
endeavors
have
been
devoted
to
developing
smart
microneedles
that
can
respond
and
interact
with
pathophysiological
environments.
Here,
novel
bioinspired
adaptable
indwelling
therapeutic
exosome
encapsulation
are
presented
diabetic
wound
healing
by
a
combined
fabrication
of
template
replication
3D
transfer
printing.
Such
composed
mesenchymal
stem
cell
(MSC)‐exosomes‐encapsulated
adjustable
poly(vinyl
alcohol)
(PVA)
hydrogel
needle
tips
detachable
3M
medical
tape
supporting
substrate.
As
the
mechanical
strength
PVA
is
ionically
responsive
due
Hofmeister
effects,
hardness
resultant
microneedle
be
upregulated
sulfate
ions
ensure
skin
penetration
softened
nitrate
after
tip–substrate
detachment
adapt
surrounding
tissue
release
exosomes.
Because
MSC‐exosomes
effectively
activate
fibroblasts,
vascular
endothelial
cells,
macrophages,
demonstrated
function
promoting
regeneration
in
full‐thickness
cutaneous
wounds
rat
models.
These
features
indicate
practical
values
clinical
prospects
regeneration.
Smart Medicine,
Journal Year:
2024,
Volume and Issue:
3(3)
Published: July 1, 2024
Chinese
medicine
is
identified
as
a
candidate
for
wound
healing.
Attempts
in
this
field
tend
to
develop
efficient
dosage
forms
delivering
with
low
side
effects.
In
paper,
we
proposed
novel
photothermal
responsive
porous
hollow
microneedles
(PRPH-MNs)
versatile
delivery
system
antibacterial
treatment.
The
PRPH-MNs
are
composed
of
resin
shells
good
mechanical
property,
hydrogel
cores,
and
graphene
oxide
hybrid
substrate.
structure
provides
sufficient
space
loading
the
drug
dispersed
hydrogel,
while
could
not
only
block
direct
contact
between
drugs
sites
but
also
provide
channels
facilitating
release
from
core.
addition,
benefiting
effect
their
substrate,
be
heated
under
near-infrared
(NIR)
irradiation
controllable
promotion
release.
Based
on
these
features,
have
proved
that
Rhein
loaded
were
effective
promoting
healing
due
property
on-demand
Thus,
believe
valuable
different
clinical
applications.
Small,
Journal Year:
2024,
Volume and Issue:
20(45)
Published: July 28, 2024
Several
natural
Chinese
herbal
medicines
have
demonstrated
considerable
potential
in
facilitating
wound
healing,
while
the
primary
concern
remains
centered
around
optimizing
formulation
and
structure
to
maximize
their
efficacy.
To
address
this,
a
microneedles
drug
delivery
system
is
proposed
that
harnesses
gelatinized
starch
key
ingredients-aloe
vera
berberine.
After
aged
well-designed
mold,
starch-based
are
fabricated
with
suitable
mechanical
strength
load
components.
The
resulting
hydrogel
microneedles,
enriched
integrated
berberine
aloe,
exhibit
antibacterial,
anti-inflammatory,
fibroblast
growth-promoting
properties,
thereby
healing
whole
process.
In
vivo
experimental
results
underscore
notable
achievements
of
early-stage
antibacterial
effects
subsequent
tissue
reconstruction,
contributing
significantly
overall
These
emphasize
advantageous
combination
traditional
medicine
presenting
novel
strategy
for
repair
opening
new
avenues
application
medicine.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(46)
Published: June 28, 2024
Abstract
Hydrogels
hold
great
promise
in
the
field
of
flexible
electronics.
Attempts
this
area
tend
to
microstructure
design
hydrogels,
giving
them
specific
adhesion
and
multi‐sensing
functions.
Here,
a
novel
phase
separation‐derived
anisotropic
adhesive
structural
color
hydrogel
film
is
presented
for
visually
The
generated
by
template
replicating
colloidal
crystal
using
separation
emulsions
hydrophilic
monomer
(acrylic
acid,
AA),
hydrophobic
(lauryl
methacrylate,
LMA),
co‐monomer
([2‐(methacryloyloxy)
ethyl]
dimethyl‐(3‐sulfopropyl)
ammonium
hydroxide
(SBMA)),
surfactants
(hexadecyl
trimethyl
bromide,
CTAB)
initiator
(ammonium
persulphate
(APS)).
appearance
results
asymmetric
morphologies
film,
imparting
with
performance.
Attributed
formation
inverse
opal
scaffold
structure,
featured
vivid
color,
showing
superior
capability
self‐reporting
mechanical
behavior.
Additionally,
benefitting
from
presence
abundant
ions,
exhibits
conductivity.
Thus,
resultant
demonstrated
stable
dual‐signal
sensing
properties
involving
color‐changing
conductivity
feedback
ability
respond
human
activities.
These
features
make
proposed
highly
potential
electronic
field.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(39), P. 26733 - 26750
Published: Sept. 6, 2024
Rescuing
or
compensating
mitochondrial
function
represents
a
promising
therapeutic
avenue
for
radiation-induced
chronic
wounds.
Adult
stem
cell
efficacies
are
primarily
dependent
on
the
paracrine
secretion
of
mitochondria-containing
extracellular
vesicles
(EVs).
However,
effective
strategies
addressing
quantity
mitochondria
and
mitochondria-delivery
system
lacking.
Thus,
in
this
study,
we
aimed
to
design
an
hydrogel
microneedle
patch
(MNP)
loaded
with
cell-derived
mitochondria-rich
EVs
gradually
release
deliver
into
wound
tissues
boost
healing.
We,
first,
used
metformin
enhance
biogenesis
thereby
increasing
(termed
"Met-EVs")
adipose-derived
cells.
To
verify
effects
Met-EVs,
established
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(20)
Published: March 16, 2023
Lipid
nanoparticle-based
drug
delivery
systems
have
a
profound
clinical
impact
on
nucleic
acid-based
therapy
and
vaccination.
Recombinant
human
insulin,
negatively-charged
biomolecule
like
mRNA,
may
also
be
delivered
by
rationally-designed
positively-charged
lipid
nanoparticles
with
glucose-sensing
elements
released
in
glucose-responsive
manner.
Herein,
we
designed
phenylboronic
quaternary
amine-type
cationic
lipids
that
can
self-assemble
into
spherical
an
aqueous
solution.
Upon
mixing
insulin
the
nanoparticles,
heterostructured
complex
is
formed
immediately
arising
from
electrostatic
attraction.
In
hyperglycemia-relevant
glucose
solution,
become
less
positively
charged
over
time,
leading
to
reduced
attraction
subsequent
release.
Compared
native
this
shows
prolonged
blood
regulation
ability
glucose-triggered
release
type
1
diabetic
mouse
model.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 31, 2024
Photonic
crystals
are
a
new
class
of
optical
microstructure
materials
characterized
by
dielectric
constant
that
varies
periodically
with
space
and
features
photonic
bandgap.
Inspired
natural
such
as
butterfly
scales,
series
artificial
developed
for
use
in
integrated
platforms,
biosensing,
communication,
other
fields.
Among
them,
colloidal
(CPCs)
have
gained
widespread
attention
due
to
their
excellent
properties
advantages,
ease
preparation
functionalization.
This
work
reviews
the
classification
self-assembly
principles
CPCs,
details
some
latest
biomedical
applications
large-area,
high-quality
CPCs
prepared
using
advanced
methods,
summarizes
existing
challenges
CPC
construction
application,
anticipates
future
development
directions
optimization
strategy.
With
further
advancements,
expected
play
more
critical
role
biosensors,
drug
delivery,
cell
research,
fields,
bringing
significant
benefits
research
clinical
practice.
Smart Medicine,
Journal Year:
2024,
Volume and Issue:
3(3)
Published: July 25, 2024
Oral
disease
is
a
severe
healthcare
challenge
that
diminishes
people's
quality
of
life.
Functional
hydrogels
with
suitable
biodegradability,
biocompatibility,
and
tunable
mechanical
properties
have
attracted
remarkable
interest
been
developed
for
treating
oral
diseases.
In
this
review,
we
present
up-to-date
research
on
the
management
dental
caries,
endodontics,
periapical
periodontitis,
depending
progression
The
strategies
mucosal
diseases
salivary
gland
are
then
classified.
After
that,
focus
application
related
to
tumor
therapy
tissue
defects.
Finally,
review
prospects
restrictions
perspectives
utilization
in
treatment.
We
believe
will
promote
advancement
more
amicable,
functional
personalized
approaches
