Highly Photostable Deep-NIR Chromophore with a Superior Molar Absorptivity for Efficient Photothermal Therapy

Industrial & Engineering Chemistry Research, Journal Year: 2024, Volume and Issue: 63(3), P. 1239 - 1247

Published: Jan. 11, 2024

Organic chromophores, especially those absorbing/emitting in the deep near-infrared region (deep-NIR, i.e., 800 nm and beyond), have prominent potentials photothermal cancer therapy due to tissue penetration good biocompatibility. Although many cyanine/DAD-based agents been successfully used clinical preclinical trials, they are limited poor photostability molar absorptivity. There is still an imperative demand for robust deep-NIR exhibiting high We previously invented a bright push–pull fluorochromic scaffold (EC5) absorbing emitting spectral region. In this work, EC5 was rationally tailored suppress its fluorescence emission promote conversion efficiency. This led design synthesis of EC5PM EC5DP by changing two or four N-alkyl groups headgroups into phenyl groups, respectively. The intensities completely quenched TICT effect associated with N–Ph bonds. particular, maximally absorbs at longer wavelength 879 superior photostability, efficiency 54.8%, extinction coefficient 224,000 M–1 cm–1. Upon encapsulation DSPE-mPEG2000 micelles, phototoxicity showcased 4T1 cells remarkable therapeutic tumors tumor-bearing mouse model. work provides rational strategy ultraphotostable highly organic chromophores therapy.

Language: Английский

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2D Black Ferroelectric Perovskite Nanocatalysts Enable Defect Modulation‐Augmented Piezocatalytic Glioma Therapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Enhancing the efficacy of glioma treatment poses a significant challenge. Ferroelectric nanomaterials, renowned for their remarkable piezoelectric properties, generate reactive oxygen species (ROS) when exposed to external stimuli or specific environmental conditions. This characteristic positions them as promising platforms highly effective cancer therapies. In this study, two‐dimensional (2D) black Bi 4 Ti 3 O 12 ferroelectric perovskite nanocatalysts with engineered vacancies are designed potent sources ROS efficient therapy. The band bending due polarization and narrowed bandgap induced by vacancy defects effectively enhance carrier separation, suppress recombination rates, markedly increase production. Moreover, mitochondrial dysfunction activation mitogen‐activated protein kinase (MAPK) pathways contribute favorable anti‐tumor effects. vitro cellular‐level assessments in vivo antineoplastic evaluations unequivocally demonstrate enhanced cytotoxicity tumor suppression enabled piezo‐catalytic strategy. research underscores role defect engineering optimizing effectiveness semiconductors catalytically inducing apoptosis cells.

Language: Английский

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Preclinical Assessment of Living Therapeutic Materials: State-of-Art and Challenges

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Living Therapeutic Materials represent a promising technology to tackle therapeutic problems that classical materials cannot address. Despite the advancements on new functions of these devices, applications, and fabrication methods, preclinical evaluation is still very limited challenges appear when incorporating living devices in contact with host. This critical bottleneck path translation clinic. Therefore, we have compiled literature Materials, focus microorganism-based materials, summarized investigations carried out assess their biocompatibility, safety, efficacy. We split three parts: vitro, ex vivo, vivo assessments, where describe common practices remaining challenges.

Language: Английский

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Mitochondrial biogenesis microcarriers break membrane barriers for endogenous nucleus pulposus repair

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160668 - 160668

Published: Feb. 1, 2025

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Biomimetic cascade-released hydrogel scaffolds from microfluidics for efficient T cell recruitment and expansion

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152467 - 152467

Published: May 21, 2024

Language: Английский

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Targeted Microglial Membrane-Coated MicroRNA Nanosponge Mediates Inhibition of Glioblastoma

ACS Nano, Journal Year: 2024, Volume and Issue: 18(42), P. 29089 - 29105

Published: Oct. 11, 2024

Glioblastoma (GBM) is the most prevalent primary brain tumor. Recent research emphasizes crucial role of microRNAs (miRs) in GBM pathogenesis, and targeting miRs offers an effective approach for precise therapy. However, inhibiting a single miR may not be sufficient due to compensatory mechanisms GBM. Herein, we developed miR-nanosponge capable specifically capturing multiple involved tumor growth, migration, invasion, angiogenesis, creation immunosuppressive microenvironment, thereby offering comprehensive treatment Coated with BV2 cell membrane (BM) enhanced blood–brain barrier (BBB) crossing targeting, BM@miR-nanosponge targets miR-9, miR-21, miR-215, miR-221, significantly progression modulating immune system thorough eradication. The notably extended median survival time GBM-bearing mice outperformed standard drug temozolomide (TMZ). This study introduces miR-based strategy highlights importance associated

Language: Английский

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Biomimetic Hydrogel Strategies for Cancer Therapy

Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 437 - 437

Published: June 30, 2024

Recent developments in biomimetic hydrogel research have expanded the scope of biomedical technologies that can be used to model, diagnose, and treat a wide range medical conditions. Cancer presents one most intractable challenges this arena due surreptitious mechanisms it employs evade detection treatment. In order address these challenges, design principles adapted beat cancer at its own game. Biomimetic strategies are inspired by natural biological systems offer promising opportunities for developing life-changing methods detect, treat, cure various types static metastatic cancers. particular, focusing on cellular subcellular phenomena serve as fundamental drivers peculiar behavioral traits provide rich insights into eradicating all manifestations. This review highlights nanocomposite hydrogels contribute therapies via enhanced drug delivery modeling mechanobiology relation metastasis synergistic sensing systems. Creative efforts amplify advance development more effective will discussed alignment with international collaborative goals cancer.

Language: Английский

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Photothermal Responsive Microcarriers Encapsulated With Cangrelor and 5‐Fu for Colorectal Cancer Treatment

Small Methods, Journal Year: 2023, Volume and Issue: 8(7)

Published: Dec. 21, 2023

Abstract Localized chemotherapy is emerging as a potential strategy for cancer treatment due to its low systemic toxicity. However, the immune evasion of tumor cells and lack an intelligent design delivery system limit clinical application. Herein, photothermal responsive microcarriers are designed by microfluidic electrospray colorectal treatment. The loaded with Cangrelor, 5‐FU MXene (G‐M@F/C+NIR) show sustained antiplatelet drug thus inhibiting activity platelets, interactions platelet‐tumor cell, well invasion epithelial‐mesenchymal transition (EMT). In addition, chemotherapeutics effect provided enable inhibit proliferation migration. vivo studies validate that G‐M@F/C+NIR significantly inhibites growth, decreased expression Ki‐67 in vascular endothelial growth factor (VEGF) microenvironment, while increased E‐cadherin. It believe means proposed microcarriers, synergistic platelet inhibition, chemotherapy, therapy can find practical applications

Language: Английский

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A preclinical design approach for translation of biohybrid photosensitive nanoplatform for photodynamic therapy of breast cancer

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 378, P. 543 - 558

Published: Dec. 25, 2024

Language: Английский

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