2D Black Ferroelectric Perovskite Nanocatalysts Enable Defect Modulation‐Augmented Piezocatalytic Glioma Therapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Enhancing the efficacy of glioma treatment poses a significant challenge. Ferroelectric nanomaterials, renowned for their remarkable piezoelectric properties, generate reactive oxygen species (ROS) when exposed to external stimuli or specific environmental conditions. This characteristic positions them as promising platforms highly effective cancer therapies. In this study, two‐dimensional (2D) black Bi 4 Ti 3 O 12 ferroelectric perovskite nanocatalysts with engineered vacancies are designed potent sources ROS efficient therapy. The band bending due polarization and narrowed bandgap induced by vacancy defects effectively enhance carrier separation, suppress recombination rates, markedly increase production. Moreover, mitochondrial dysfunction activation mitogen‐activated protein kinase (MAPK) pathways contribute favorable anti‐tumor effects. vitro cellular‐level assessments in vivo antineoplastic evaluations unequivocally demonstrate enhanced cytotoxicity tumor suppression enabled piezo‐catalytic strategy. research underscores role defect engineering optimizing effectiveness semiconductors catalytically inducing apoptosis cells.

Language: Английский

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Nanomaterial‐Triggered Ferroptosis and Cuproptosis in Cancer Therapy

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Cancer remains one of the leading causes death individuals globally. Conventional treatment techniques like chemotherapy and radiation often suffer various drawbacks toxicity drug resistance. The study cell has been predominantly focused on classical forms apoptosis, but role metal ions in governing controlled is a fascinating less explored area. Metal‐mediated process where triggers via unique mechanism. Nanomaterial‐based strategies have gained attention for their ability to deliver precise therapeutic agents while also triggering Regulated Cell Death (RCD) mechanisms cancer cells. recently discovered metal‐mediated cuproptosis ferroptosis can be used as they selectively drug‐resistant cancer. Nano material‐based delivery system targeted sites. In this review, we given some idea about mechanism (ferroptosis cuproptosis) how initiate deaths using nanomaterials treatment.

Language: Английский

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Recent Advances in the Design and Biocidal Mechanisms of Room-temperature Catalytic Nanomaterials for Efficient Inactivation of Bioaerosols

Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 106449 - 106449

Published: April 1, 2025

Language: Английский

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Breathable core–shell microneedle patches for diabetic wound treatment

Materials Futures, Journal Year: 2025, Volume and Issue: 4(2), P. 025402 - 025402

Published: April 23, 2025

Abstract Microneedles have demonstrated valuable applications in diabetic wound management. Many endeavors are devoted to developing microneedles with well-designed structures and enhanced functions. Herein, we present an elaborate microneedle patch breathability for healing by a multi-step replication method. The consists of breathable porous supporting substrate core–shell tips involving poly (vinyl alcohol) shells loaded antimicrobial peptides (PVA@AMPs shell) crosslinked Gelma cores encapsulated exosomes (Gelma@exo core). PVA was ROS-responsive linker, which results degradation the shell inflammatory microenvironment, thus inducing release AMPs inhibit bacteria. Further, continuously from exposed Gelma@exo core, promoting tissue regeneration regulating immune response. Besides, high porosity makes patches more suitable chronic wounds. Based on these features, it that exhibits desirable performance vivo animal tests. Thus, believe proposed remarkable potential related fields.

Language: Английский

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Biomineralize Mitochondria in Metal‐Organic Frameworks to Promote Mitochondria Transplantation From Non‐Tumorigenic Cells Into Cancer Cells

Smart Medicine, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 26, 2025

Mitochondria are crucial to cellular physiology, and growing evidence highlights the significant impact of mitochondrial dysfunction in diabetes, aging, neurodegenerative disorders, cancers. Therefore, transplantation shows great potential for therapeutic use treating these diseases. However, process is notably challenging due very low efficiency rapid loss bioactivity post-isolation, leading poor reproducibility reliability. In this study, we develop a novel strategy form nanometer-thick protective shell around isolated mitochondria using Metal-Organic Frameworks (MOFs) through biomineralization. Our findings demonstrate that encapsulation method effectively maintains at least 4 weeks room temperature. Furthermore, intracellular delivery significantly enhanced surface functionalization MOFs with polyethyleneimine (PEI) cell-penetrating peptide Tat. The successful from non-tumorigenic cells into cancer results notable tumor-suppressive effects. Taken together, our technology represents advancement research, particularly on understanding their role cancer. It also lays groundwork utilizing as agents treatment.

Language: Английский

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Cu‐Intercalated MoS₂ Nanosheets with Enhanced Antibacterial Activity for Treatment of Bacterial Keratitis

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Bacterial keratitis (BK) is a critical and sight-threatening corneal infection that significantly impairs the quality of life. Due to widespread antibiotic-resistant microbes slow development in antibiotics, there an increasingly growing demand create new antimicrobial agents for treatment BK. Herein, copper-intercalated molybdenum disulfide (Cu-MoS2) nanosheets are constructed by intercalating Cu into interlayer structure MoS2 via intercalation chemistry, which not only introduces Fenton reaction but also modulates electronic MoS2. Cu-MoS2 can convert H2O2 more toxic reactive oxygen species (ROS), thereby exhibiting excellent bactericidal performance against Staphylococcus aureus (S. aureus), methicillin-resistant (MRSA) Escherichia coli (E. coli) at room temperature dark. Animal experiments indicated effectively treat BK caused MRSA. This work demonstrates chemistry as novel effective strategy tune antibacterial agent with no reliance on light has great potential therapeutic effects clinical drug-resistant

Language: Английский

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“On-demand” nanosystem-integrated microneedles for amplified triple therapy against recalcitrant bacteria and biofilm growth

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101327 - 101327

Published: Nov. 6, 2024

Phototherapy has emerged to eradicate recalcitrant bacteria without causing drug resistance, but it is often accompanied by considerable limitations owing a high tolerance of heat and oxidative damage, leading low efficiency monotherapy unwanted side effects. Assuming that employing antimicrobial peptides (AMPs) disrupt bacterial membranes could reduce tolerance, multifunctional "on-demand" nanosystem based on zeolitic imidazolate framework-8 (ZIF-8) with metal ions for intrinsic antibacterial activity was constructed potently kill methicillin-resistant

Language: Английский

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Biomimetic Materials for Antibacterial Applications

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

The rise of antibiotic resistance poses a critical threat to global health, necessitating the development novel antibacterial strategies mitigate this growing challenge. Biomimetic materials, inspired by natural biological systems, have emerged as promising solution in context. These mimicking entities such plants, animals, cells, viruses, and enzymes, offer innovative approaches combat bacterial infections effectively. This review delves into integration biomimicry with materials science develop agents that are not only effective but also biocompatible less likely induce resistance. study explores design function various biomimetic highlighting their therapeutic potential anti-infection applications. Further, provides comprehensive summary recent advancements field, illustrating how these been engineered enhance efficacy safety. discusses challenges facing transition from laboratory clinical settings, scalability, cost-effectiveness, long-term stability. Lastly, vast opportunities hold for future therapy, suggesting continued research multidisciplinary collaboration will be essential realize full potential.

Language: Английский

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Nitric Oxide-Releasing Mesoporous Hollow Cerium Oxide Nanozyme-Based Hydrogel Synergizes with Neural Stem Cell for Spinal Cord Injury Repair

ACS Nano, Journal Year: 2024, Volume and Issue: 19(2), P. 2591 - 2614

Published: Dec. 26, 2024

Neural stem cell (NSCs) transplantation is a promising therapeutic strategy for spinal cord injury (SCI), but its efficacy greatly limited by the local inhibitory microenvironment. In this study, based on l-arginine (l-Arg)-loaded mesoporous hollow cerium oxide (AhCeO2) nanospheres, we constructed an injectable composite hydrogel (AhCeO2-Gel) with microenvironment modulation capability. AhCeO2-Gel protected NSCs from oxidative damage eliminating excess reactive oxygen species while continuously delivering Nitric Oxide to lesion of SCI in pathological microenvironment, latter which effectively promoted neural differentiation NSCs. The process was confirmed be closely related up-regulation cAMP-PKA pathway after NO-induced calcium ion influx. addition, significantly polarization microglia toward M2 subtype as well enhanced regeneration nerves and myelinated axons. prepared bioactive system also efficiently facilitated integration transplanted host circuits, replenished damaged neurons, alleviated neuroinflammation, inhibited glial scar formation, thus accelerating recovery motor function rats. Therefore, synergized has great potential integrated treat comprehensively reversing

Language: Английский

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