In Vivo Screening of Barcoded Gold Nanoparticles Elucidates the Influence of Shapes for Tumor Targeting DOI
Xu-Dong Huang, Zhicheng Le, M. Ba

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 24, 2024

Abstract Gold nanoparticles (NPs) are promising for cancer therapy due to their versatile shapes, optical properties, adjustable sizes, and facile functionalization. However, diverse physicochemical complex in vivo environments, cellular heterogeneity lead markedly different interactions with cells, impacting reproducibility application selection. To address this, we implemented a DNA barcoding system label gold NPs varying surface modifications tumor delivery optimization. Six NP species, comprising three shapes (sphere, rod, triangle) two sizes (40 nm, 80 nm), were tagged unique barcodes. Barcodes demonstrated minimal detachment, no interference cell interactions, resistance DNase digestion. Next‐generation sequencing revealed that sphere exhibited poor vitro uptake but superior targeting, likely enhanced endothelial reduced macrophage clearance. Additionally, nm nanotriangles displayed excellent targeting both vivo. Supporting experiments validated these findings. demonstrate practical utility, the applied siRNA photothermal breast model. This study pioneers integration of systematically explore shape, size, delivery.

Language: Английский

Multiple bacteria recognition mechanisms and their applications DOI

Xuechi Yin,

Jinrui Shan,

Leina Dou

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 517, P. 216025 - 216025

Published: June 18, 2024

Language: Английский

Citations

7
Recent advances in AIE-based platforms for cancer immunotherapy DOI
Ziyi Chen, Xue‐Ping Li, Qian Liu

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 1 - 19

Published: Oct. 5, 2024

Language: Английский

Citations

2
Coordination chemistry in CRISPR-Cas-based point of care testing: A review of molecular probe development and applications DOI

Ying Jia,

Mashooq Khan,

Tangbin Hu

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216081 - 216081

Published: July 16, 2024

Language: Английский

Citations

1
In Vivo Screening of Barcoded Gold Nanoparticles Elucidates the Influence of Shapes for Tumor Targeting DOI
Xu-Dong Huang, Zhicheng Le, M. Ba

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 24, 2024

Abstract Gold nanoparticles (NPs) are promising for cancer therapy due to their versatile shapes, optical properties, adjustable sizes, and facile functionalization. However, diverse physicochemical complex in vivo environments, cellular heterogeneity lead markedly different interactions with cells, impacting reproducibility application selection. To address this, we implemented a DNA barcoding system label gold NPs varying surface modifications tumor delivery optimization. Six NP species, comprising three shapes (sphere, rod, triangle) two sizes (40 nm, 80 nm), were tagged unique barcodes. Barcodes demonstrated minimal detachment, no interference cell interactions, resistance DNase digestion. Next‐generation sequencing revealed that sphere exhibited poor vitro uptake but superior targeting, likely enhanced endothelial reduced macrophage clearance. Additionally, nm nanotriangles displayed excellent targeting both vivo. Supporting experiments validated these findings. demonstrate practical utility, the applied siRNA photothermal breast model. This study pioneers integration of systematically explore shape, size, delivery.

Language: Английский

Citations

1