Molecular Imprinting: Green Perspectives and Strategies

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(30)

Published: June 18, 2021

Abstract Advances in revolutionary technologies pose new challenges for human life; response to them, global responsibility is pushing modern toward greener pathways. Molecular imprinting technology (MIT) a multidisciplinary mimic simulating the specific binding principle of enzymes substrates or antigens antibodies; along with its rapid progress and wide applications, MIT faces challenge complying green sustainable development requirements. With identification environmental risks associated unsustainable MIT, aspect termed has emerged developed. However, so far, no clear definition been provided appraise MIT. Herein, implementation process chemistry demonstrated mnemonic device form an acronym, GREENIFICATION, proposed present principles. The entire greenificated surveyed, including element choice, polymerization implementation, energy input, strategies, waste treatment, recovery, as well impacts these processes on operator health environment. Moreover, assistance upgraded instrumentation deploying goals considered. Finally, future perspectives are presented provide more complete picture road map pave way further development.

Language: Английский

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The Past and the Future of Langmuir and Langmuir–Blodgett Films

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 6459 - 6513

Published: Feb. 3, 2022

The Langmuir–Blodgett (LB) technique, through which monolayers are transferred from the air/water interface onto a solid substrate, was first method to allow for controlled assembly of organic molecules. With its almost 100 year history, it has been inspiration most methods functionalize surfaces and produce nanocoatings, in addition serving explore concepts molecular electronics nanoarchitectonics. This paper provides an overview history Langmuir LB films, including potential use devices discussion on why films seldom considered practical applications today. Emphasis is then given two areas where these offer unique opportunities, namely, mimicking cell membrane models exploiting nanoarchitectonics sensors, investigate recognitions, assemble machines. promising topics short- long-term prospects technique also highlighted.

Language: Английский

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Nanoarchitectonics: what's coming next after nanotechnology?

Nanoscale Horizons, Journal Year: 2021, Volume and Issue: 6(5), P. 364 - 378

Published: Jan. 1, 2021

The nanoarchitectonics concept has the ability to bridge nanoscale science and visual size materials. final goal of approaches is creation living-creature-like functional material systems from simple objects.

Language: Английский

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Ubiquitination Flow Repressors: Enhancing Wound Healing of Infectious Diabetic Ulcers through Stabilization of Polyubiquitinated Hypoxia‐Inducible Factor‐1α by Theranostic Nitric Oxide Nanogenerators

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(45)

Published: Sept. 23, 2021

Current treatments for diabetic ulcers (DUs) remain unsatisfactory due to the risk of bacterial infection and impaired angiogenesis during healing process. The increased degradation polyubiquitinated hypoxia-inducible factor-1α (HIF-1α) compromises wound efficacy. Therefore, maintenance HIF-1α protein stability might help treat DU. Nitric oxide (NO) is an intrinsic biological messenger that functions as a ubiquitination flow repressor antibacterial agent; however, its clinical application in DU treatment hindered by difficulty controlling NO release. Here, intelligent near-infrared (NIR)-triggered nanogenerator (SNP@MOF-UCNP@ssPDA-Cy7/IR786s, abbreviated SNP@UCM) presented. SNP@UCM represses ubiquitination-mediated proteasomal inhibiting interaction with E3 ubiquitin ligases under NIR irradiation. Increased expression endothelial cells enhances sites, promoting vascular growth factor (VEGF) secretion cell proliferation migration. also enables early detection infections ROS-mediated killing bacteria. potential utility further demonstrated infected full-thickness model first reported HIF-1α-stabilizing advanced nanomaterial, materials engineering offer facile, mechanism-based method management.

Language: Английский

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Preparation methods of different nanomaterials for various potential applications: A review

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1281, P. 135148 - 135148

Published: Feb. 12, 2023

Language: Английский

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Bioinspired 2D Isotropically Fatigue‐Resistant Hydrogels

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(8)

Published: Dec. 10, 2021

Engineering conventional hydrogels with muscle-like anisotropic structures can efficiently increase the fatigue threshold over 1000 J m-2 along alignment direction; however, perpendicular to is still as low ≈100-300 , making them nonsuitable for those scenarios where isotropic properties are desired. Here, inspired by distinct structure-properties relationship of heart valves, a simple yet general strategy engineer unprecedented resistance, record-high 1,500 two arbitrary in-plane directions reported. The two-step process involves formation preferentially aligned lamellar micro/nanostructures through bidirectional freeze-casting process, followed compression annealing, synergistically contributing extraordinary resistance crack propagation. study provides viable means fabricating soft materials isotropically extreme properties, thereby unlocking paths apply these advanced toward applications including robotics, flexible electronics, e-skins, and tissue patches.

Language: Английский

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Material Evolution with Nanotechnology, Nanoarchitectonics, and Materials Informatics: What will be the Next Paradigm Shift in Nanoporous Materials?

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(7)

Published: Oct. 13, 2021

Abstract Materials science and chemistry have played a central significant role in advancing society. With the shift toward sustainable living, it is anticipated that development of functional materials will continue to be vital for sustaining life on our planet. In recent decades, rapid progress has been made owing advances experimental, analytical, computational methods, thereby producing several novel useful materials. However, most problems material are highly complex. Here, best strategy via implementation three key concepts discussed: nanotechnology as game changer, nanoarchitectonics an integrator, informatics super‐accelerator. Discussions from conceptual viewpoints example developments, chiefly focused nanoporous materials, presented. It coupling these strategies together open advanced routes swift design exploratory search truly solving real‐world problems. These result evolution

Language: Английский

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There is still plenty of room for layer-by-layer assembly for constructing nanoarchitectonics-based materials and devices

Physical Chemistry Chemical Physics, Journal Year: 2021, Volume and Issue: 24(7), P. 4097 - 4115

Published: Dec. 2, 2021

While the layer-by-layer (LbL) assembly method has already reached a certain maturity, there is still plenty of room for expanding its usefulness fabrication nanoarchitectonics-based materials and devices.

Language: Английский

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Materials Nanoarchitectonics from Atom to Living Cell: A Method for Everything

Bulletin of the Chemical Society of Japan, Journal Year: 2022, Volume and Issue: 95(5), P. 774 - 795

Published: March 22, 2022

Abstract Promoted understanding of nanostructures and their functions significantly rely on rapid progress nanotechnology within a few decades. It would be fruitful way to consider materials science through regulation nanostructure regulations the basis nanotechnological accomplishments. As post-nanotechnology concept, new concept nanoarchitectonics has recently emerged as methodology produce functional from nanoscale units. In this review article, we discuss recent advances related approaches atom-scales living cell sizes. The multiscale are exemplified discussed including atom molecules nanoarchitectonics, supramolecular at cell-scale. Next, supracell-level is organization designed surfaces, sheets layered three-dimensional biofilms bioinks, challenges for cells liquid interface. All formed with fundamental units, atoms, molecules, nanomaterials, therefore, basic units can hypothetically applied any kind material. Therefore, could method everything in an analogy theory physics.

Language: Английский

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Strong π–π Stacking Stabilized Nanophotosensitizers: Improving Tumor Retention for Enhanced Therapy for Large Tumors in Mice

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(6)

Published: Nov. 11, 2021

Conventional photosensitizers (PSs) often show poor tumor retention and are rapidly cleared from the bloodstream, which is one of key hindrances to guarantee precise efficient photodynamic therapy (PDT) in vivo. In this work, a photosensitizer assembly nanosystem that sharply enhances up ≈10 days present. The PSs synthesized by meso-substituting anthracene onto BODIPY scaffold (AN-BDP), then self-assembles into stable nanoparticles (AN-BDP NPs) with amphiphilic block copolymers due strong intermolecular π-π interaction anthracene. Additionally, incorporated excites PSs, producing singlet oxygen under red-light irradiation. Although AN-BDP NPs can completely suppress regular test size tumors (≈100 mm3 ) one-time radiation, only 12% growth inhibition rate observed case large-size (≈350 same conditions. Due long-time retention, allow single-dose injection three-time light treatments, resulting an over 90%, much more than single-time radiation conventional clinically used including chlorin-e6 (Ce6) porphyrin retention. results reveal importance long time for PDT, accelerate clinical development nanophotosensitizers.

Language: Английский

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