Phytic Acid Functionalized Hierarchical Porous Metal‐Organic Framework Microspheres for Efficient Extraction of Uranium from Seawater

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Abstract Uranium is a critical resource in the development of nuclear energy, and its extraction from natural seawater has been identified as potential solution to address uranium shortages. In this study, hierarchical meso‐/micro‐ porous metal‐organic framework functionalized with phytic acid (PA) microspheres (denoted H‐UiO‐66‐PA) are rationally synthesized for efficient extraction. This unique design allowed large adsorption capacity fast kinetics, making it promising material Due hierarchically structure, H‐UiO‐66‐NH 2 materials not only provide more sites grafting PA, thus enhance capacity, but also facilitate rapid diffusion uranyl ions which can quickly effectively access interior H‐UiO‐66‐PA adsorbent. Therefore, obtained achieve an impressive absorption efficiency 6.76 mg g −1 actual within 15 days. Meanwhile, possesses good five adsorption/desorption cycles. work proposes feasible strategy constructing functional MOFs removal.

Language: Английский

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Nanomedicine with simple structure for programmable heat-shock protein inhibition and sensitized synergistic therapy

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161307 - 161307

Published: March 1, 2025

Language: Английский

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Clickable Polymer-Based Coatings for Modulating the Interaction of Metal–Organic Framework Nanocrystals with Living Cells

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Nanosized microporous metal-organic-frameworks (NMOFs) serve as versatile drug delivery systems capable of navigating complex microenvironments and interacting with cells in specific tissues. The physicochemical properties NMOFs, such size, composition, porosity, colloidal stability, external surface functionalization are essential for their success efficient carriers. This study introduces a flexible, clickable coating using an amphiphilic polymer derivatized dibenzo cyclooctyne groups universal, postsynthetic tool. To prove its universality, nanosized MOFs different structure composition (UiO-67, NU-1000, PCN-222, ZIF-8) were produced high monodispersity coated clickable, polymer. resulting polymer-coated NMOFs display exceptional structural stability biologically relevant media. For comparative purposes, we selected two size-equivalent ZIF-8 UiO-67, which functionalized library azide-derivatized (macro)molecules, including poly(ethylene glycol), mannose, dynein-binding cell-penetrating peptide, bioorthogonal reaction. choice both 150 nm size but distinct coordination chemistries, is pivotal due to differing acid base characteristics, may potentially influence performance cellular environments. track vitro, the loaded cresyl violet, common histological stain lysosomal marker. Cellular internalization surface-functionalized was markedly governed by (macro)molecule characteristics. demonstrates that critically uptake efficiency, while also highlighting versatility effectiveness proposed strategy. In particular, one peptide demonstrated higher rate compared other NMOFs. contrast, derivatizations mannose glycol) associated substantial reduction uptake, suggesting stealth behavior. These results provide alternative engineering aiming improve targeted effectiveness.

Language: Английский

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Engineered cell membrane-cloaked metal-organic framework nanocrystals for intracellular cargo delivery

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 682, P. 31 - 40

Published: Nov. 23, 2024

Language: Английский

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