Tailored regulation of ferroptosis in periodontitis using thermosensitive ionic liquid hydrogel based on galangin/L-cysteine-decorated MoS2 nanoflowers DOI

Maomao Tang,

Rui Ma, Yang Ding

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113928 - 113928

Published: June 1, 2025

Language: Английский

Ni–Cu Bimetallic Nanozyme and Minoxidil Co-Loaded Dissolving Microneedles Reshape Hair Follicle Microenvironment for Androgenic Alopecia Treatment DOI
Beibei Wang,

Mengcheng Tang,

Yongjia Zhang

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский

Citations

0
Beacon of Hope for Age-Related Retinopathy: Antioxidative Mechanisms and Pre-Clinical Trials of Quercetin Therapy DOI Creative Commons

Ning Pu,

Siyu Li, Hao Wu

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 561 - 561

Published: May 8, 2025

Age-related retinopathy is one of the leading causes visual impairment and irreversible blindness, characterized by progressive neuronal myelin loss. The damages caused oxidation contributes to hallmarks aging represents fundamental components in pathological pathways that are thought drive multiple age-related retinopathies. Quercetin (Que), a natural polyphenol abundant vegetables, herbs, fruits, has been extensively studied for its long-term antioxidative effects mediated through diverse mechanisms. Additionally, Que derivatives exhibit broad spectrum pharmacological characteristics cellular responses induced oxidative stress, including anti-inflammatory, anti-neovascularization, regulatory, neuroprotective autophagy apoptosis processes. This review mainly focuses on mechanisms curative treatment various retinopathies, such as retinitis pigmentosa, diabetic retinopathy, macular degeneration, glaucoma. Furthermore, we discuss emerging technologies methods involving therapeutic strategies highlighting their promise clinical translation.

Language: Английский

Citations

0
Wireless In Situ Catalytic Electron Signaling‐Mediated Transcriptomic Reprogramming for Neuron Regeneration via Adaptable Antennas DOI Creative Commons

Hoi Man Iao,

Chih‐Ying Chen, Ya‐Hui Lin

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 11, 2025

Abstract Electron signaling and oxygen level are vital for regulating neural‐cell fate brain recovery. However, clinical challenges arise from the short half‐life difficulty of spatiotemporally controlled release electric signals. In this study, a wireless‐charging sustained conductive microgels (SOCO) served as an antenna on‐demand O 2 nerve regeneration is developed. Introducing “electromagnetic messenger”, using external alternating magnetic field (AMF) to enhance catalytic electrical stimulation promote reconstruction blood vessels neurons in vivo. SOCO also reduces TBI glial scarring by reducing activated microglia stellate cells, promoting infiltration new neurons. whole‐brain analyses, effective somatostatin (Sst) production inhibits gamma‐aminobutyric acid (GABA) synthesis injured areas, thereby improving function behavioral Furthermore, spatial multiomics combined with single‐cell deconvolution analysis reveals treatment reprogramming vivo transcriptome angiogenic markers (Il1a, Lgals3) GABAergic pathway via modulation GAD65/67 activity, guiding angiogenesis neuronal regeneration. This situ noncontact AMF presents messenger”‐based therapeutics neuro‐regeneration recovery TBI.

Language: Английский

Citations

0
Tailored regulation of ferroptosis in periodontitis using thermosensitive ionic liquid hydrogel based on galangin/L-cysteine-decorated MoS2 nanoflowers DOI

Maomao Tang,

Rui Ma, Yang Ding

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113928 - 113928

Published: June 1, 2025

Language: Английский

Citations

0