A chemomechanical model of sperm locomotion reveals two modes of swimming DOI Creative Commons
Chenji Li, Brato Chakrabarti, Pedro Castilla

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: April 10, 2022

The propulsion of mammalian spermatozoa during reproduction relies on the spontaneous periodic oscillation their flagella. These oscillations are driven internally by coordinated action ATP-powered dynein motors that exert active sliding forces between microtubule doublets, resulting in bending waves propagate along flagellum and enable locomotion cell through viscous medium. In this work, we present a chemomechanical model freely swimming spermatozoon uses sliding-control flagellar axoneme capturing coupling motor kinetics with elastic deformations accounts for effect non-local hydrodynamic interactions sperm head flagellum. Nonlinear simulations equations shown to produce realistic beating patterns trajectories, which analyze as function number activity. Our results demonstrate velocity does not vary monotonically activity, but instead displays two local maxima corresponding distinct modes swimming, each characterized qualitatively different waveforms trajectories.

Language: Английский

A chemomechanical model of sperm locomotion reveals two modes of swimming DOI Creative Commons
Chenji Li, Brato Chakrabarti, Pedro Castilla

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: April 10, 2022

The propulsion of mammalian spermatozoa during reproduction relies on the spontaneous periodic oscillation their flagella. These oscillations are driven internally by coordinated action ATP-powered dynein motors that exert active sliding forces between microtubule doublets, resulting in bending waves propagate along flagellum and enable locomotion cell through viscous medium. In this work, we present a chemomechanical model freely swimming spermatozoon uses sliding-control flagellar axoneme capturing coupling motor kinetics with elastic deformations accounts for effect non-local hydrodynamic interactions sperm head flagellum. Nonlinear simulations equations shown to produce realistic beating patterns trajectories, which analyze as function number activity. Our results demonstrate velocity does not vary monotonically activity, but instead displays two local maxima corresponding distinct modes swimming, each characterized qualitatively different waveforms trajectories.

Language: Английский

Citations

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