Human Vaccines & Immunotherapeutics,
Journal Year:
2024,
Volume and Issue:
20(1)
Published: Dec. 10, 2024
Immunogenic
cell
death
(ICD)
is
a
distinct
type
of
stress-induced
regulated
that
can
lead
to
adaptive
immune
responses
and
the
establishment
immunological
memory.
ICD
exhibits
both
similarities
differences
when
compared
apoptosis
other
non-apoptotic
forms
(RCD).
The
interplay
between
ICD-mediated
immunosurveillance
against
cancer
ability
cells
evade
influences
host-tumor
interaction.
Consequently,
restoration
development
effective
strategies
induce
have
emerged
as
crucial
considerations
in
treatment
within
context
immunotherapy.
To
enhance
comprehension
setting
cancer,
this
paper
examines
interconnected
responsive
pathways
associated
with
ICD,
corresponding
biomarkers
indicative
mechanisms
through
which
tumors
subvert
ICD.
Additionally,
review
explores
for
reinstating
therapeutic
potential
harnessing
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(9), P. 10243 - 10256
Published: April 24, 2024
Immunotherapy
has
emerged
as
a
promising
cancer
treatment
method.
However,
it
previously
been
centered
on
adjuvant
therapy,
often
falling
short
preoperative
of
solid
cancers,
largely
attributed
to
the
hypoxic
and
immunosuppressive
microenvironments
untreated
tumors.
Herein,
we
develop
multifunctional
nanoagent
based
edge-oxidized
graphene
(EOG)
for
tumor
imaging
neoadjuvant
thermal
immunotherapy.
EOG,
readily
synthesized
from
selective
oxidation
mechanical
exfoliation
flakes,
exhibits
good
biocompatibility
remarkable
microwave
absorption
capabilities
owing
its
large
aromatic
domains.
Consequently,
demonstrated
utility
in
both
microwave-induced
thermoacoustic
therapy
mouse
hepatoma
model.
Furthermore,
EOG-based
is
combined
with
immunotherapy,
which
can
significantly
reduce
volume
inhibit
growth.
A
mechanistic
study
reveals
that
energy
alleviates
hypoxia,
promotes
immunogenic
cell
death,
ultimately
enhances
antitumor
immune
responses.
This
work
pioneers
microwave-based
imaging-guided
immunotherapy
strategy
tumors
cell-level
pathway
involved
suppression.
Tissue Engineering Part B Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 30, 2024
There
is
a
critical
need
for
novel
approaches
to
translate
cell
therapy
and
regenerative
medicine
clinical
practice.
Magnetic
targeting
with
site
specificity
has
started
open
avenues
in
these
fields
as
potential
therapeutic
platform.
gaining
popularity
the
field
of
biomedicine
due
its
ability
concentrate
retain
at
target
while
minimizing
deleterious
effects
off-target
sites.
It
regarded
relatively
straightforward
safe
approach
wide
range
applications.
This
review
discusses
latest
advancements
magnetic
using
endocytosed
surface-bound
nanoparticles
well
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
38, P. 321 - 330
Published: May 9, 2024
Given
their
dangerous
effects
on
the
nervous
system,
neurotoxins
represent
a
significant
threat
to
public
health.
Various
therapeutic
approaches,
including
chelating
agents,
receptor
decoys,
and
toxin-neutralizing
antibodies,
have
been
explored.
While
prophylactic
vaccines
are
desirable,
it
is
oftentimes
difficult
effectively
balance
safety
efficacy
given
highly
nature
of
neurotoxins.
To
address
this,
we
report
here
nanovaccine
against
that
leverages
detoxifying
properties
cell
membrane-coated
nanoparticles.
A
genetically
modified
line
with
constitutive
overexpression
α7
nicotinic
acetylcholine
developed
as
membrane
source
generate
biomimetic
nanoparticles
can
irreversibly
bind
α-bungarotoxin,
model
neurotoxin.
This
abrogates
biological
activity
toxin,
enabling
resulting
nanotoxoid
be
safely
delivered
into
body
processed
by
immune
system.
When
co-administered
an
immunological
adjuvant,
strong
humoral
response
α-bungarotoxin
generated
protects
vaccinated
mice
lethal
dose
toxin.
Overall,
this
work
highlights
potential
using
genetic
modification
strategies
develop
formulations
various
threats.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 26, 2024
Abstract
Mild
photothermal
therapy
(MPTT)
has
emerged
as
a
promising
therapeutic
modality
for
attenuating
thermal
damage
to
the
normal
tissues
surrounding
tumors,
while
heat‐induced
upregulation
of
heat
shock
proteins
(HSPs)
greatly
compromises
curative
efficacy
MPTT
by
increasing
cellular
thermo‐tolerance.
Ferroptosis
been
identified
suppress
overexpression
HSPs
accumulation
lipid
peroxides
and
reactive
oxygen
species
(ROS),
but
is
restricted
overexpressed
glutathione
(GSH)
in
tumor
microenvironment
undesirable
ROS
generation
efficiency.
Herein,
synergistic
strategy
based
on
mutual
enhancement
ferroptosis
proposed
cleaving
recover
cell
sensitivity.
A
facile
method
fabricating
series
Fe‐based
metal‐quinone
networks
(MQNs)
coordinated
assembly
representative
FTP
MQNs
possess
high
conversion
efficiency
(69.3
%).
Upon
808
nm
laser
irradiation,
not
only
trigger
effective
induce
apoptosis
more
significantly,
potentiate
Fenton
reaction
marked
GSH
consumption
boost
ferroptosis,
reinforced
effect
turn
can
alleviate
resistance
declining
HSP70
defense
reducing
ATP
levels.
This
study
provides
valuable
rationale
constructing
large
library
achieving
ferroptosis.
Human Vaccines & Immunotherapeutics,
Journal Year:
2024,
Volume and Issue:
20(1)
Published: Dec. 10, 2024
Immunogenic
cell
death
(ICD)
is
a
distinct
type
of
stress-induced
regulated
that
can
lead
to
adaptive
immune
responses
and
the
establishment
immunological
memory.
ICD
exhibits
both
similarities
differences
when
compared
apoptosis
other
non-apoptotic
forms
(RCD).
The
interplay
between
ICD-mediated
immunosurveillance
against
cancer
ability
cells
evade
influences
host-tumor
interaction.
Consequently,
restoration
development
effective
strategies
induce
have
emerged
as
crucial
considerations
in
treatment
within
context
immunotherapy.
To
enhance
comprehension
setting
cancer,
this
paper
examines
interconnected
responsive
pathways
associated
with
ICD,
corresponding
biomarkers
indicative
mechanisms
through
which
tumors
subvert
ICD.
Additionally,
review
explores
for
reinstating
therapeutic
potential
harnessing
