Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(21), P. 6296 - 6301
Published: May 15, 2024
Ion
transport
through
nanoporous
two-dimensional
(2D)
membranes
is
predicted
to
be
tunable
by
controlling
the
charging
status
of
membranes'
planar
surfaces,
behavior
which
though
remains
assessed
experimentally.
Here
we
investigate
ion
intrinsically
porous
made
2D
metal-organic-framework
layers.
In
presence
certain
cations,
observe
a
linear-to-nonlinear
transition
ionic
current
in
response
applied
electric
field,
analogous
cation
gating
effect
biological
channels.
Specifically,
currents
saturate
at
transmembrane
voltages
exceeding
few
hundreds
millivolts,
depending
on
concentration
cations.
This
attributed
binding
cations
tuning
states
there
and
affecting
entry/exit
process
translocating
ions.
Our
work
also
provides
as
candidates
for
building
nanofluidic
devices
with
properties.
Cell Death Discovery,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: Sept. 4, 2023
Abstract
Acid-sensing
ion
channel
1a
(ASIC1a),
a
prominent
member
of
the
acid-sensing
(ASIC)
superfamily
activated
by
extracellular
protons,
is
ubiquitously
expressed
throughout
human
body,
including
nervous
system
and
peripheral
tissues.
Excessive
accumulation
Ca
2+
ions
via
ASIC1a
activation
may
occur
in
acidified
microenvironment
blood
or
local
ASIC1a-mediated
‑induced
apoptosis
has
been
implicated
numerous
pathologies,
neurological
disorders,
cancer,
rheumatoid
arthritis.
This
review
summarizes
role
modulation
various
signaling
pathways
across
different
disease
states
to
provide
insights
for
future
studies
on
underlying
mechanisms
development
therapeutic
strategies.
Langmuir,
Journal Year:
2024,
Volume and Issue:
40(41), P. 21866 - 21875
Published: Oct. 3, 2024
Bipolar
nanopores,
with
asymmetric
charge
distributions,
can
induce
significant
ionic
current
rectification
(ICR)
at
ultra-short
lengths,
finding
potential
applications
in
nanofluidic
devices,
energy
conversion,
and
other
related
fields.
Here,
simulations,
we
investigated
the
characteristics
of
ion
transport
modulation
ICR
inside
bipolar
nanopores.
With
nanopores
half-positive
half-negative
surfaces,
most
phenomenon
appears
various
concentrations.
In
these
cases,
ratios
are
independent
electrolyte
types.
cases
where
have
oppositely
charged
surfaces
different
to
mobility
anions
cations.
The
pore
length
surface
density
enhance
ICR.
As
increases,
first
increase
then
approach
their
saturation
which
is
determined
by
density.
External
charges
promote
mainly
due
enhancement
enrichment
external
conductance.
effective
width
exterior
under
conditions
also
explored,
inversely
proportional
salt
concentration,
linearly
diameter,
density,
applied
voltage.
Our
results
may
provide
guidance
for
design
porous
membranes.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(21), P. 6296 - 6301
Published: May 15, 2024
Ion
transport
through
nanoporous
two-dimensional
(2D)
membranes
is
predicted
to
be
tunable
by
controlling
the
charging
status
of
membranes'
planar
surfaces,
behavior
which
though
remains
assessed
experimentally.
Here
we
investigate
ion
intrinsically
porous
made
2D
metal-organic-framework
layers.
In
presence
certain
cations,
observe
a
linear-to-nonlinear
transition
ionic
current
in
response
applied
electric
field,
analogous
cation
gating
effect
biological
channels.
Specifically,
currents
saturate
at
transmembrane
voltages
exceeding
few
hundreds
millivolts,
depending
on
concentration
cations.
This
attributed
binding
cations
tuning
states
there
and
affecting
entry/exit
process
translocating
ions.
Our
work
also
provides
as
candidates
for
building
nanofluidic
devices
with
properties.
