Pyruvate Kinase M2‐Responsive Release of Paclitaxel and Indoleamine 2,3‐Dioxygenase Inhibitor for Immuno‐Chemotherapy of Nonsmall Cell Lung Cancer DOI Creative Commons

Haisi Wu,

Xianbao Sun, Kaiming Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Abstract Paclitaxel (PTX) is a first‐line chemotherapeutic drug for non‐small cell lung cancer (NSCLC) but it can induce indoleamine 2,3‐dioxygenase (IDO) activation, which severely lowers down its immuno‐chemotherapeutic effect. To address this issue, smart peptide hydrogelator Nap–Phe–Phe–Phe–Lys–Ser–Thr–Gly–Gly–Lys–Ala–Pro–Arg–OH ( Nap‐T ), co‐assembles with PTX and an IDO inhibitor GDC0919 to form hydrogel GP@Gel Nap‐T, rationally designed. Upon specific phosphorylation by pyruvate kinase M2 (PKM2), overexpressed biomarker of NSCLC, gradually converted Nap–Phe–Phe–Phe–Lys–Ser–Thr(H 2 PO 3 )–Gly–Gly–Lys–Ala–Pro–Arg–OH Nap‐Tp leading dehydrogelation sustained release within NSCLC tissues. The released exerts chemotherapy on cells as well immunogenic death induction, while promotes the effect through inhibition. We find that enhances infiltration tumor‐infiltrating immune reduces number immunosuppressive in either tumor tissues or tumor‐draining lymph nodes, thus enhancing immuno‐chemotherapy toward NSCLC. With PKM2‐responsive strategy, platform might be applied treatment clinic near future.

Language: Английский

Stimulus‐Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy DOI Creative Commons
Haoyu Yu,

Rongyao Gao,

Yuxin Liu

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(1)

Published: Nov. 20, 2023

Abstract Deregulated inflammations induced by various factors are one of the most common diseases in people's daily life, while severe inflammation can even lead to death. Thus, efficient treatment has always been hot topic research medicine. In past decades, as a potential biomaterial, stimuli‐responsive hydrogels have focus attention for due their excellent biocompatibility and design flexibility. Recently, thanks rapid development nanotechnology material science, more efforts made develop safer, personal effective therapy some frequent but tough such sepsis, rheumatoid arthritis, osteoarthritis, periodontitis, ulcerative colitis. Herein, from recent studies articles, conventional emerging delivery anti‐inflammatory drugs summarized. And prospects clinical translation future also discussed further detail.

Language: Английский

Citations

49
Design of Fatigue‐Resistant Hydrogels DOI
Zilong Han, Yuchen Lu, Shaoxing Qu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(21)

Published: Jan. 4, 2024

Abstract Hydrogels are made tough to resist crack propagation. However, for seamless integration into devices and machines, it necessitates robustness against cyclic loads. Central this objective is enhancing fatigue resistance, an indispensable attribute facilitating the optimal performance of hydrogels within a multitude biological contexts, spanning various plant animal tissues, as well diverse biomedical engineering areas. In review, recent research concerning behavior hydrogels, presenting comprehensive consolidation inherent mechanisms that underpin strategies aimed at fortifying summarized. A critical facet in architectural blueprint fatigue‐resistant emphasized, involving imposition spatial constraints upon main chains tips, thereby effectuating protracted delay their fracture initiation during prolonged loading. The multiscale encompassing networks, interactions, media, structures stands pivotal factor design hydrogels. It hoped review will considerably propel pragmatic deployment across array applications, thus catalyzing advancements multiple fields.

Language: Английский

Citations

36
Physical strategies to engineer supramolecular composite hydrogels for advanced biomedical applications DOI

Sravan Baddi,

Auphedeous Y. Dang-i,

Fengli Gao

et al.

Progress in Materials Science, Journal Year: 2025, Volume and Issue: 151, P. 101428 - 101428

Published: Jan. 9, 2025

Language: Английский

Citations

2
Smart core-shell microneedles for psoriasis therapy: In situ self-assembly of calcium ion-coordinated dexamethasone hydrogel DOI

Xinni He,

Wanchen Zhao,

Huihui Xu

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 786 - 796

Published: Jan. 25, 2025

Language: Английский

Citations

2
Supramolecular co-assembled hybrid hydrogels for antibacterial therapy DOI Creative Commons
Zakia Riaz,

Sravan Baddi,

Chuanliang Feng

et al.

Supramolecular Materials, Journal Year: 2024, Volume and Issue: 3, P. 100064 - 100064

Published: Jan. 18, 2024

Bacterial infections arising from antibiotic-resistant strains represent a formidable global health threat. In the realm of antibacterial therapies, supramolecular hydrogels stand out with unique advantages owing to their adaptable and flexible non-covalent interactions diverse biomolecules. Their ability encapsulate variety biologically active agents through co-assembly further amplifies efficacy, endowing these hybrid spectrum functionalities within unified system. Various encompass self-healing, injectability, tissue adhesion, facile drug loading, controlled release mechanisms, biocompatibility, properties, antioxidative attributes. This review article delves into two categories hydrogels: i) those intrinsic attributes ii) co-assembled formed integration an assortment agents, including various nanomaterials, antibiotics, compounds derived natural sources, polymers. The anticipated role hydrogels, coupled contemporary medical technologies devices, is paramount in development highly effective secure platforms for therapy. Furthermore, addresses current challenges while elucidating prospective future advancements this field.

Language: Английский

Citations

5
Exploring a Solvent Dependent Strategy to Control Self‐Assembling Behavior and Cellular Interaction in Laminin‐Mimetic Short Peptide based Supramolecular Hydrogels DOI

Shambhavi Kashyap,

Vijay Kumar Pal, Sweta Mohanty

et al.

ChemBioChem, Journal Year: 2024, Volume and Issue: 25(8)

Published: Feb. 23, 2024

Self-assembled hydrogels, fabricated through diverse non-covalent interactions, have been extensively studied in regenerative medicines. Inspired from bioactive functional motifs of ECM protein, short peptide sequences shown remarkable abilities to replicate the intrinsic features natural extracellular milieu. In this direction, we two hydrophobic derived laminin protein i. e., IKVAV and YIGSR. Based on substantial hydrophobicity these peptides, selected a co-solvent approach as suitable gelation technique that included different concentrations DMSO an organic phase along with aqueous solution containing 0.1 % TFA. These laminin-based peptides limited solubility physiological environment showed significantly enhanced higher content water. The resulted extensive intermolecular interactions led formation hydrogels higher-order entangled network improved mechanical properties. Interestingly, by simply modulating content, highly tunable gels were accessed same gelator domain displayed differential physicochemical Further, cellular studies substantiated potential laminin-derived enhancing cell-matrix thereby reinforcing their applications tissue engineering.

Language: Английский

Citations

5
Hydrogel-based drug delivery systems - a review DOI

Kamini Bhardwaj,

Dinesh Puri

Polymer-Plastics Technology and Materials, Journal Year: 2024, Volume and Issue: 63(16), P. 2213 - 2236

Published: June 30, 2024

Hydrogels are unique polymer materials that possess hydrophilic chains, allowing them to effectively retain a considerable amount of water within their interstitial structures. The first hydrogel, developed in 1955 by Professor Lim and Wichterle from Prague, was specifically designed for manufacturing contact lenses. Hydrogel has the ability absorb significant without dissolving. These gels consist three-dimensional (3D) network structure composed cross-linked polymers. can undergo changes properties or behavior response different stimuli. There two main problems addressed when using hydrogels: Firstly, it is imperative conduct more vivo research how they behave after being implanted humans. Secondly, it's crucial create new, effective, ecologically responsible ways make hydrogels. have emerged as unparalleled vehicles drug delivery, particularly context brain spinal cord lesions, heavy metal removal, tissue engineering, biosensor, regeneration, cancer, bioprinting, soft robots, photonics, perfumery food industry. In future, will be profitable focus on development sophisticated biopolymer-based hydrogels, combining natural polymers with elastin-cellulose elastin-alginate mixes. Such developments would very helpful regeneration.

Language: Английский

Citations

4
Biomimetic PVA Hydrogel and MMT reinforced TPU Water-Lubricated Bearing Materials for Superior Frictional Properties and Wear Resistance DOI
Zhiwei Guo,

Yu Bi,

Zumin Wu

et al.

Wear, Journal Year: 2025, Volume and Issue: unknown, P. 205786 - 205786

Published: Jan. 1, 2025

Language: Английский

Citations

0
Advances in cellulose-based hydrogels: tunable swelling dynamics and their versatile real-time applications DOI Creative Commons
Md. Mahamudul Hasan Rumon

RSC Advances, Journal Year: 2025, Volume and Issue: 15(15), P. 11688 - 11729

Published: Jan. 1, 2025

Cellulose-derived hydrogels have emerged as game-changing materials in biomedical research, offering an exceptional combination of water absorption capacity, mechanical resilience, and innate biocompatibility.

Language: Английский

Citations

0
Deceptive Ceropegia sandersonii uses an arabinogalactan for trapping its fly pollinators DOI Creative Commons

Philipp Feichtlbauer,

Mario Schubert,

Caroline Mortier

et al.

New Phytologist, Journal Year: 2025, Volume and Issue: unknown

Published: April 20, 2025

Summary Many plant species have evolved surfaces that reduce insect attachment. Among such plants are deceptive trap flowers of Ceropegia . Their gliding zones consist convex epidermal cells, each with a bristle‐like central protuberance and single small liquid droplet on its tip. So far, the molecular physical mechanisms controlling function these droplets unknown. We analyzed sandersonii by microscopic approaches, studied how they behave when getting in contact feet fly pollinators, their chemical composition. The contaminate feet, which solidify. As main component, negatively charged polysaccharide containing β1,3‐galactan backbone Rha‐α1,4‐GlcA‐β1,6‐[Araf‐α1,3‐]Gal‐β1,6 side chains or truncated versions it was identified. structure represents rudimentary version an arabinogalactan, is supported binding to β‐ d ‐glucosyl Yariv reagent. Candidates arabinogalactan proteins were identified might be connected. high amount GlcA helps explain unusual characteristics droplets, like viscoelasticity hygroscopy. add new arabinogalactans discuss why polymer well suited for catching temporarily trapping pollinators.

Language: Английский

Citations

0