Pyruvate Kinase M2‐Responsive Release of Paclitaxel and Indoleamine 2,3‐Dioxygenase Inhibitor for Immuno‐Chemotherapy of Nonsmall Cell Lung Cancer DOI Creative Commons

Haisi Wu,

Xianbao Sun, Kaiming Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Abstract Paclitaxel (PTX) is a first‐line chemotherapeutic drug for non‐small cell lung cancer (NSCLC) but it can induce indoleamine 2,3‐dioxygenase (IDO) activation, which severely lowers down its immuno‐chemotherapeutic effect. To address this issue, smart peptide hydrogelator Nap–Phe–Phe–Phe–Lys–Ser–Thr–Gly–Gly–Lys–Ala–Pro–Arg–OH ( Nap‐T ), co‐assembles with PTX and an IDO inhibitor GDC0919 to form hydrogel GP@Gel Nap‐T, rationally designed. Upon specific phosphorylation by pyruvate kinase M2 (PKM2), overexpressed biomarker of NSCLC, gradually converted Nap–Phe–Phe–Phe–Lys–Ser–Thr(H 2 PO 3 )–Gly–Gly–Lys–Ala–Pro–Arg–OH Nap‐Tp leading dehydrogelation sustained release within NSCLC tissues. The released exerts chemotherapy on cells as well immunogenic death induction, while promotes the effect through inhibition. We find that enhances infiltration tumor‐infiltrating immune reduces number immunosuppressive in either tumor tissues or tumor‐draining lymph nodes, thus enhancing immuno‐chemotherapy toward NSCLC. With PKM2‐responsive strategy, platform might be applied treatment clinic near future.

Language: Английский

Physiologically compatible MWCNT-incorporated PNCPG self-healed ionic breathable hydrogel for wearable smart strain sensor application DOI
Animesh Sinha, Doheon Koo, Junho Kim

et al.

Nano Today, Journal Year: 2024, Volume and Issue: 61, P. 102606 - 102606

Published: Dec. 24, 2024

Language: Английский

Citations

1
Biochemical Signal‐Induced Supramolecular Hydrogelation for Structured Free‐Standing Soft Material Formation DOI

Dineshkumar Bharathidasan,

Akshay Sunil Salvi,

Suryasarathi Bose

et al.

Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: 24(12)

Published: Nov. 15, 2024

Cells coordinate their activity and regulate biological processes in response to chemical signals. Mimicking natural processes, control over the formation of artificial supramolecular materials is high interest for application biology medicine. Supramolecular material that can form signals important development autonomously responsive materials. Herein, a hydrogel system reported enabling situ generation hydrogelators specific signal. Using self-immolative chemistry, spatial structured free-standing objects via providing H

Language: Английский

Citations

1
Hydrogel-based Cardiac Patches for Myocardial Infarction Therapy: Recent Advances and Challenges DOI Creative Commons
Zhenqiu Liu, Zhi Zheng,

Jiahao Xie

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101331 - 101331

Published: Nov. 7, 2024

Myocardial infarction (MI) remains the leading cause of death related to cardiovascular diseases globally, presenting a significant clinical challenge due specificity lesion site and limited proliferative capacity cardiomyocytes (CMs) for repairing infarcted myocardium. Extensive studies reported so far has focused on utilization hydrogel-based cardiac patches MI treatment, highlighting their promising mechanical properties, conductivity, ability remodel microenvironment post-repair. However, majority developed have been myocardial tissue surface via suturing or adhesive administration. Suturing inevitably leads additional damage fragile myocardium, while uneven application adhesives may result in patch displacement compromised drug release. Based these critical issues, we systematically summarize advantages drawbacks using hydrogel treatment with emphasis elucidating various design strategies. Specifically, first describe changes pathological following MI. Next, discuss biomimetic types patches, functional design, corresponding strategies adaptation, emphasizing adhesion mechanisms, wet strategies, fabrication techniques patches. Finally, address potential challenges prospects hydrogels as therapy. The review is believed provide theoretical guidance development new therapeutic effectively treatment.

Language: Английский

Citations

0
Hydration effect and molecular geometry conformation as critical factors affecting the longevity stability of G4-structure-based supramolecular hydrogels DOI
Jiang Liu, Lideng Cao, Zheng Wang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(38), P. 9713 - 9726

Published: Jan. 1, 2024

Nucleoside-derived supramolecular hydrogels based on G4-structures have been extensively developed in the biomedical sector and recognized for superior excellent biocompatibility biodegradability. However, limited longevity stability present a significant challenge. Chemical modifications molecular structure shown to enhance of G4-structure-based hydrogels, but precise way which impacts consequently affects properties hydrogel remains be elucidated. This issue represents notable challenge field, restricts their further applications some extent. In this study, single crystals Gd, αGd αGd* were cultivated compared with G. Notably, before crystal structures all natural nucleosides, exception had determined. The investigation into self-assembly four guanosine analogs at atomic scale revealed that formation G-quartets is critical ability form hydrogels. sugar ring geometry conformation (an intrinsic factor) disorder strength hydration effect (extrinsic factors) are vital maintaining G4-structures. rapid cooling changes conformation, organic solvent effect, can improve instead chemical modifications. Consequently, lifespan was extended from 2 h over one week. advancement expected offer insights future research designing developing

Language: Английский

Citations

0
Pyruvate Kinase M2‐Responsive Release of Paclitaxel and Indoleamine 2,3‐Dioxygenase Inhibitor for Immuno‐Chemotherapy of Nonsmall Cell Lung Cancer DOI Creative Commons

Haisi Wu,

Xianbao Sun, Kaiming Li

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Abstract Paclitaxel (PTX) is a first‐line chemotherapeutic drug for non‐small cell lung cancer (NSCLC) but it can induce indoleamine 2,3‐dioxygenase (IDO) activation, which severely lowers down its immuno‐chemotherapeutic effect. To address this issue, smart peptide hydrogelator Nap–Phe–Phe–Phe–Lys–Ser–Thr–Gly–Gly–Lys–Ala–Pro–Arg–OH ( Nap‐T ), co‐assembles with PTX and an IDO inhibitor GDC0919 to form hydrogel GP@Gel Nap‐T, rationally designed. Upon specific phosphorylation by pyruvate kinase M2 (PKM2), overexpressed biomarker of NSCLC, gradually converted Nap–Phe–Phe–Phe–Lys–Ser–Thr(H 2 PO 3 )–Gly–Gly–Lys–Ala–Pro–Arg–OH Nap‐Tp leading dehydrogelation sustained release within NSCLC tissues. The released exerts chemotherapy on cells as well immunogenic death induction, while promotes the effect through inhibition. We find that enhances infiltration tumor‐infiltrating immune reduces number immunosuppressive in either tumor tissues or tumor‐draining lymph nodes, thus enhancing immuno‐chemotherapy toward NSCLC. With PKM2‐responsive strategy, platform might be applied treatment clinic near future.

Language: Английский

Citations

0