Bioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations
Biomaterials Research,
Journal Year:
2025,
Volume and Issue:
29
Published: Jan. 2, 2025
As
a
complex
and
dynamically
regulated
process,
wound
healing
is
collaboratively
carried
out
by
multiple
types
of
cells.
However,
the
precise
mechanisms
which
these
cells
contribute
to
immune
regulation
are
not
yet
fully
understood.
Although
research
on
bone
regeneration
has
been
quite
extensive,
application
bioactive
glass
(BG)
in
skin
tissue
repair
remains
still
relatively
underexplored.
The
review
focuses
principles
latest
progress
using
BGs
for
repair,
highlighting
BGs’
special
performance
requirements,
including
biological
activity,
biocompatibility,
biodegradability,
antibacterial
properties,
emphasizing
their
potential
repair.
In
addition,
play
substantial
role
regulating
various
inflammatory
(neutrophils,
macrophages,
mast
cells,
etc.)
[fibroblasts,
vascular
endothelial
mesenchymal
stem
(MSCs),
etc.]
involved
healing.
also
covers
recent
developments
composite
materials
incorporating
BGs,
demonstrating
ability
promote
angiogenesis,
inhibit
biofilms,
improve
responses
chronic
wounds.
Furthermore,
have
shown
effectiveness
promoting
epithelial
collagen
deposition
burn
wounds
as
well
applications
scar
management
post-tumor
resection
care.
Finally,
we
summarize
our
views
challenges
directions
emerging
field
future.
Language: Английский
Multifunctional hydrogel dressing composed of trichosanthes polysaccharide and carboxymethyl chitosan accelerate cachectic wound healing and reduce scar hyperplasia
Guihua Chen,
No information about this author
Chenxiao Yang,
No information about this author
Xingyu Xu
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et al.
Carbohydrate Polymers,
Journal Year:
2025,
Volume and Issue:
357, P. 123378 - 123378
Published: Feb. 18, 2025
Language: Английский
The role of macrophages in hypertrophic scarring: molecular to therapeutic insights
L Shen,
No information about this author
Yao Zhou,
No information about this author
Jie Gong
No information about this author
et al.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 28, 2025
Hypertrophic
Scar
(HS)
is
a
common
fibrotic
disease
of
the
skin,
usually
caused
by
injury
to
deep
dermis
due
trauma,
burns,
or
surgical
injury.
The
main
feature
HS
thickening
and
hardening
often
accompanied
itching
pain,
which
seriously
affects
patient's
quality
life.
Macrophages
are
involved
in
all
stages
genesis
through
phenotypic
changes.
M1-type
macrophages
primarily
function
early
inflammatory
phase
secreting
pro-inflammatory
factors,
while
M2-type
actively
contribute
tissue
repair
fibrosis.
Despite
advances
understanding
pathogenesis,
precise
mechanisms
linking
macrophage
changes
fibrosis
remain
incompletely
elucidated.
This
review
addresses
these
gaps
discussing
pathological
formation,
at
different
pathways
influence
progression.
Furthermore,
emerging
technologies
for
treatment
novel
therapeutic
strategies
targeting
highlighted,
offering
potential
avenues
improved
prevention
HS.
Language: Английский
Phe–Phe-Based Macroscopic Supramolecular Hydrogel Construction Strategies and Biomedical Applications
Chem & Bio Engineering,
Journal Year:
2024,
Volume and Issue:
1(8), P. 664 - 677
Published: Aug. 12, 2024
Since
the
phenylalanine
(Phe)
dipeptide
moiety
is
referred
to
as
an
essential
structure
for
building
amyloid-β
peptide
from
Alzheimer's
disease,
its
wonderful
assembly
ability
form
nanofibers
has
been
extensively
studied.
Cross-linked
Phe–Phe-based
can
construct
networks,
thus
encapsulating
drugs
supramolecular
hydrogels.
Recently,
scientists
have
proposed
a
variety
of
macroscopic
hydrogels
and
used
them
in
biomedical
applications.
Therefore,
we
summarize
construction
strategies
list
their
represented
applications
(e.g.,
wound
healing,
eye
protection,
cancer
therapy,
etc.)
since
birth
In
addition,
present
perspectives
challenges
Language: Английский