Emerging Delivery Systems for Enabling Precision Nucleic Acid Therapeutics

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Nucleic acid therapeutics represent a highly promising treatment approach in modern medicine, treating diseases at the genetic level. However, these face numerous challenges practical applications, particularly regarding their stability, effectiveness, cellular uptake efficiency, and limitations delivering them specifically to target tissues. To overcome obstacles, researchers have developed various innovative delivery systems, including viral vectors, lipid nanoparticles, polymer inorganic protein carriers, exosomes, antibody oligonucleotide conjugates, DNA nanostructure-based systems. These systems enhance therapeutic efficacy of nucleic drugs by improving targeting specificity, half-life vivo. In this review, we systematically discuss different types drugs, analyze major barriers encountered delivery, summarize current research progress emerging We also highlight latest advancements application for diseases, infectious cancer, brain wound healing. This review aims provide comprehensive overview drug systems' status future directions integrating nanotechnology, biomaterials science, gene editing technologies, emphasizing transformative potential precision medicine.

Language: Английский

A review of RNA nanoparticles for drug/gene/protein delivery in advanced therapies: Current state and future prospects

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139532 - 139532

Published: Jan. 5, 2025

Language: Английский

Functionalized polyesters based on valerolactones and [12]aneN₃ as effective non-viral gene vectors in HepG2 cells

Polymer Chemistry, Journal Year: 2024, Volume and Issue: 15(34), P. 3480 - 3491

Published: Jan. 1, 2024

Block polyesters with BODIPY and [12]aneN 3 moieties showed efficient cell-specific nucleic acid expression anti-tumor gene therapy in vitro .

Language: Английский