Published: Jan. 1, 2024
Language: Английский
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160557 - 160557
Published: Feb. 1, 2025
Language: Английский
Citations
1
Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12
Published: Feb. 4, 2025
Aim To develop a new drug delivery system (DDS) that can load chemotherapy agents and photosensitizer chlorin e6 (Ce6) onto the pores surfaces of mesoporous silica nanoparticle (MSN) separately.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 27, 2025
Intracerebral hemorrhage (ICH), a specific subtype within the spectrum of stroke disorders, is characterized by its high mortality and significant risk long-term disability. The initiation progression neuroinflammation play central critical role in pathophysiology ICH. NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, protein complex involved initiating inflammation, focus this article. Microglia astrocytes roles inflammatory damage process associated with neuroinflammation. NLRP3 inflammasome expressed both types glial cells, activation drives these cells toward pro-inflammatory phenotype, which exacerbates brain. However, regulatory relationship between two cell remains to be explored. Targeting inflammasomes microglia or may provide an effective approach mitigate following This article first provides overview composition mechanisms inflammasome. Subsequently, it summarizes recent research findings on novel signaling pathways that regulate activity. Finally, we reviewed progress inhibitors, highlighting clinical translation potential certain candidates. These inhibitors hold promise as innovative strategies for managing inflammation
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101652 - 101652
Published: March 12, 2025
Intracerebral hemorrhage (ICH) remains a life-threatening condition due to its high mortality and limited treatment options. This study explores novel therapeutic strategy using engineered exosomes derived from endothelial progenitor cells (EPC-EXOs) improve ICH outcomes. EPC-EXOs were modified with CD47-enriched red blood cell membrane via co-extrusion enhance their anti-phagocytic properties, thereby reducing degradation by activated microglia after ICH. A minimally invasive endoscopic-guided delivery system was developed facilitate the targeted intranasal administration of these (m-Oe-EXOs), allowing direct entry into brain tissue. We confirmed m-Oe-EXOs' retention effective distribution in brain. Functional analysis demonstrated that significantly promoted proliferation, migration, angiogenesis microvascular (BMECs), proteomic identifying HSP90 as key protein activating Akt pathway BMECs. In vivo, m-Oe-EXOs efficacy improving blood-brain barrier integrity, hematoma volume, enhancing neurological recovery rats. Collectively, our findings highlight potential invasive, an innovative approach for treatment, providing new insights targeted, exosomes-based regenerative therapies.
Language: Английский
Citations
0
Advanced Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Ischemic stroke represents one of the leading cerebrovascular diseases with a high rate mortality and disability globally. To date, there are no effective clinical drugs available to improve long-term outcomes for post-stroke patients. A novel nucleic acid agent circSCMH1 which can promote sensorimotor function recovery in rodent nonhuman primate animal models has been found. However, still delivery challenges overcome its implementation. Besides, effects on cognitive functions remain unexplored. Herein, lipid nanoparticle circSCMH1@LNP1 is established deliver explore therapeutic efficacy comprehensively. Distribution experiments demonstrate that intranasal administration significantly increases distribution peri-infarct region reduces non-specific accumulation other organs compared intravenous injection. Therapeutic results indicate promotes synaptic plasticity, vascular repair, neuroinflammation relief, myelin sheath formation, thereby achieving enhanced mice. In conclusion, this research presents simple LNP system efficient via repair brain injury. It envisioned study may bridge crucial gap between basic translational application, paving way implementation patient management.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0