Tetrahedral DNA Nanostructure‐Modified Nanocoating for Improved Bioaffinity and Osseointegration of Titanium

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Abstract Titanium (Ti) is extensively used in the medical field because of its excellent biomechanical properties; however, how to precisely fabricate Ti surfaces at a nanoscale remains challenging. In this study, DNA nanocoating system functionalize via series sequential reactions involving hydroxylation, silanization, and click chemistry developed. Tetrahedral nanostructures (TDNs) two different sizes (≈7 30 nm) are assembled characterized for subsequent surface attachment. vitro vivo assays demonstrated significantly enhanced cell adhesion, spreading, proliferation, osteogenesis, osseointegration on modified with 30‐nm TDNs, compared slightly improved effects 7‐nm TDNs. Mechanistic studies showed that focal adhesion pathway contributed bioaffinity as evidenced by upregulated expression vinculin activation Akt signaling pathway. Moreover, under inflammatory or hypoxic conditions, TDNs maintained cellular performance comparable normal suggesting broader adaptability nanoparticles. Thus, better achieved following modification summary, proposed DNA‐guided provides novel efficient strategy nanofabrication Ti.

Language: Английский

Smart nucleic acid nanodrug delivery system for precision therapeutics

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216673 - 216673

Published: April 3, 2025

Language: Английский

Multifunctional DNA Nanomaterials: A New Frontier in Rheumatoid Arthritis Diagnosis and Treatment

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

DNA nanomaterials offer promising advancements in addressing the challenges of rheumatoid arthritis (RA) through targeted drug delivery, biomarker detection, and therapeutic innovation.

Language: Английский