Critical role of single drop microextraction for drug isolation from complex matrix towards efficient pharmaceutical analysis: Advances and challenges

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118163 - 118163

Published: Jan. 1, 2025

Language: Английский

---

Rapid and Facile Organic Ion-Associate Liquid-Phase Extraction and Spectrophotometric Quantification of Nitrite in Environmental Water Samples

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1044 - 1044

Published: Feb. 25, 2025

Nitrite is a health and environmental hazard pollutes water sources globally, but sensitive, rapid, facile quantification methods are lacking. Herein, we report method for extracting quantifying low-concentration nitrite in surface using minimal sample solvent volumes. The reacted with sulfanilamide N-1-naphthylethylenediammonium dichloride (NED), yielding an azo dye extraction into organic ion-associate liquid phase (IALP) formed situ ethylhexyloxypropylammonium dodecyl sulfate ions. addition of sodium acetate increased the pH, decreasing cation charge from +2 to +1, improving efficiency. Further, adding NaCl doubled IALP volume, reduced required standing time, minimally affected absorbance, concentrated HCl enhanced absorbance intensity via protonation. Crucially, achieved 30-fold concentration factor compared traditional pre-treatment methods, even without centrifugation, as well limit detection 0.09 µg NO2-N/L. Spiked recovery tests river seawater samples (93-103%) matched those established methods. Digital imaging IALP-extracted lake yielded 0.4 efficient approach detection, enabling rapid monitoring spectrophotometry digital imaging.

Language: Английский

---

Rapid Isolation and Identification of Betaine From Massa Medicata Fermentata and Its Quantification by High Performance Liquid Chromatography Coupled With Solid‐Phase Extraction

Separation Science Plus, Journal Year: 2025, Volume and Issue: 8(3)

Published: March 1, 2025

ABSTRACT Liu Shenqu (Massa Medicata Fermentata [MMF]) is a natural fermented product of flour (and/or wheat bran) and five medicinal herbs, Prunus armeniaca , Vigna umbellata Artemisia annua Polygonum hydropiper Xanthium strumarium . Unprocessed, stir‐fried, charred MMF has been used therapeutically in China for over thousand years to treat conditions such as dyspepsia, abdominal distension, diarrhea. Variations quantities, fermentation conditions, processing procedures across different production regions can influence the quality products, ultimately affecting their efficacy. Therefore, it essential establish robust qualitative quantitative methods control MMF. In this study, betaine, bioactive compound, was identified via TLC, isolated using preparative TLC analyzed NMR spectroscopy Ultrasonic extraction betaine from samples optimized orthogonal experimental design. Following aluminum oxide (OH − type) solid‐phase extraction, simple, rapid, accurate HPLC method developed quantification utilizing HILIC column. Analysis 58 commercially available batches revealed that concentrations 49 (84.5%) ranged 0.75 4.0 mg/g, whereas only 9 contained below 0.5 mg/g. Notably, levels were significantly lower products compared with unprocessed ones ( p < 0.001), suggesting may serve potential biomarker

Language: Английский

---

Hydrophobic Deep Eutectic Solvents as New Supported Liquid Membranes for Extraction of β‐Blockers by Hollow Fiber–Electromembrane Extraction

Journal of Separation Science, Journal Year: 2025, Volume and Issue: 48(4)

Published: April 1, 2025

ABSTRACT In this work, an electromembrane extraction method is presented to extract some β‐blockers in biological samples. A new hydrophobic deep eutectic solvent, as a green was synthesized. The solvent immobilized the wall pores of hollow fiber membrane and used supported liquid membrane. β‐Blockers were transported from sample solution through SLM, including tris‐(2‐ethylhexyl) phosphate, into acceptor phase located lumen fiber. High‐performance chromatography with ultraviolet detection has been separate analyze β‐blockers. Effective parameters on efficiency such molar ratio (2:1), voltage (75 V), type ion carrier its concentration (tris‐(2‐ethylhexyl) 5%), pH donor phases (ultrapure water 100 mM HCl), length (7 cm), time (20 min), stirring speed (600 rpm), salt effect (0%) investigated optimized. provides decent linearity by coefficient determination values higher than 0.9946. Limits range 0.25–3.3 ng mL −1 , limits quantification found 0.75–10.0 water. Finally, successfully determine concentrations real urine plasma samples relative recoveries between 90.6% 108.6%.

Language: Английский

---

MASS SPECTROMETRY-BASED HIGH-THROUGHPUT SAMPLE TREATMENT METHODS FOR ANALYSIS OF XENOBIOTICS IN HUMAN BIOFLUIDS

Advances in Sample Preparation, Journal Year: 2025, Volume and Issue: 14, P. 100183 - 100183

Published: April 28, 2025

Language: Английский

---

Green Liquid-Phase Microextraction Using Nonanoic Acid as a Novel Extractant for the Spectrophotometric Determination of Rhodamine B in Cosmetics

Analytical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: July 24, 2024

A new method for separating and concentrating Rhodamine B (RhB) in cosmetics has been developed using nonanoic acid liquid-phase microextraction (NA-LPmE) with spectrophotometric determination. Nonanoic is a novel environmentally friendly extractant that was used as single component the isolation. In contrast, supramolecular solvents deep eutectic are often combined mixture. The simple, quick, accurate, friendly. appropriate parameters (the volume of NA, pH, sample volume, matrix effects) were optimized these conditions resulted suitable linear range (20.5–1000 µg L−1), low detection limit (6.2 high pre-concentration factor (40). NA-LPmE successfully extracted determined RhB several employs small green solvent determination rapid analysis. combination first time.

Language: Английский

---

An eco-friendly kapok fiber-supported liquid microextraction using natural deep eutectic solvent as extractant for convenient biological samples preparations: A proof-of-concept study

Sustainable Chemistry and Pharmacy, Journal Year: 2024, Volume and Issue: 42, P. 101814 - 101814

Published: Oct. 23, 2024

Language: Английский

---