A Comprehensive Review on Deep Eutectic Solvents: Their Current Status and Potential for Extracting Active Compounds from Adaptogenic Plants

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4767 - 4767

Published: Oct. 9, 2024

Deep eutectic solvents (DESs) have attracted attention from researchers as novel compounds for extracting active substances because of their negligible toxicity, polarity, and ability to be tailored depending on the experiment. In this review, we discuss deep a promising medium extraction adaptogenic compounds. comparison traditional methods, with use DESs is great alternative excessive usage harmful organic solvents. It can conducted in mild conditions, designed different precursors, enhancing versatility. Adaptogenic herbs long medicinal history, especially Eastern Asia. They exhibit unique properties through structures, including saponins, flavonoids, polysaccharides, alkaloids. Therefore, they demonstrate wide range pharmaceutical effects, such anti-inflammatory, antibacterial, anticancer abilities. Since ancient times, many been discovered are well known,

Language: Английский

---

Trends in extraction and purification methods of Lignans in plant-derived foods

Food Chemistry X, Journal Year: 2025, Volume and Issue: 26, P. 102249 - 102249

Published: Feb. 1, 2025

Lignans are widely used as dietary supplements within health foods. However, excess addition of lignans can induce adverse reactions, therefore, it is necessary to develop rapid, effective, economical, and environmentally friendly extraction purification methods enhance lignan efficiency. Recently, the advancement sample pretreatment has been primarily directed towards application novel solvents (e.g., supramolecular solvents) in dispersive liquid-liquid microextraction, miniaturization solid-phase extraction, utilization innovative adsorbent materials microextraction matrix-assisted employment subcritical water technology. Up now, no systematic review encompassed these advancements. Consequently, this provides a comprehensive overview from plant-derived foods since 2017, with particular focus on technologies new materials. It also analyzes advantages disadvantages discusses their future developing trends.

Language: Английский

---

Optimization and Characterization of Microwave‐Assisted Extraction of Polyphenols and Antioxidant Compounds From Pithecellobium Dulce Leaves: Response Surface Methodology and Artificial Neural Network Approach

Separation Science Plus, Journal Year: 2025, Volume and Issue: 8(4)

Published: March 31, 2025

ABSTRACT This study investigates the impact of different solvents and extraction methods, such as conventional solvent extraction, (using soxhlet apparatus), microwave‐assisted (MAE), on efficiency extracting phenolic antioxidant compounds. A Box–Behnken design from response surface methodology (RSM) was used to optimize MAE process conditions extract bioactive constituents Pithecellobium dulce , using water an aqueous mixture (70 [acetone]/29.5 [water]/0.5 [acetic acid], v/v/v). In addition, artificial neural network (ANN) utilized for optimization, whereas Fourier transform infrared spectroscopy characterizes polyphenolic The results ANN were found be more substantial compared RSM. Optimum are determined powder‐to‐solvent ratio 26:17 mL a treatment time 17–29 s, resulting in 586.226 mg GAE/g total polyphenol content 93.44% activity, higher than that acetic acid mixture. Furthermore, exhibits additional statistical variables coefficient determination ( R 2 ) each response. yields obtained 525.94 ± 7.51 284.43 6.13 (solvent extraction), 154.37 2.7 (conventional extraction). concludes can alternative technique methods polyphenols leaves with water. When considering effectiveness, outperforms methodology.

Language: Английский

---

A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 9, 2025

Abstract Lignans derived from Schisandra chinensis have attracted significant attention for their diverse pharmacological activities and clinical potential. This review presents a comprehensive analysis of the properties lignans, including antioxidant, anti-inflammatory, neuroprotective, hepatoprotective, antibacterial/viral, antidiabetic anticancer effects. Their multifaceted mechanisms action hold promise therapeutic areas such as cancer, neurodegenerative diseases metabolic disorders, aligning with urgent needs. Additionally, this explores pharmacokinetics these bioactive compounds, highlighting challenges in absorption, distribution, metabolism excretion, which impact bioavailability. Recent advancements drug delivery systems are discussed, potential to enhance efficacy settings. Furthermore, synergistic effects combining lignans other agents considered strategy increase efficacy. Future research is imperative identify additional active components elucidate novel action, paving way expanded applications unlocking full disease prevention treatment.

Language: Английский

---

Ultrasonic-assisted extraction and biological activities of traditional Chinese/Mongolian medical herb Artemisia ordosica Krasch. using natural deep eutectic solvents

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113669 - 113669

Published: April 1, 2025

Language: Английский

---

Investigation of the Extraction of Chlorogenic Acid From Honeysuckle and Its Biological Activity Based on Deep Eutectic Solvents

Separation Science Plus, Journal Year: 2024, Volume and Issue: 7(11)

Published: Sept. 10, 2024

ABSTRACT Honeysuckle, a traditional Chinese medicine, holds significant medicinal value, making it ubiquitous in the medical field. However, efficient extraction of chlorogenic acid from herbal medicine while maintaining its pharmacological activity remains pressing challenge. To address issues environmental pollution and inefficient using solvents, there is need to develop novel solvent. Due their low cost, nontoxic, environmentally friendly characteristics, deep eutectic solvents can be used for extracting materials preserving active ingredients during process. In this study, we examined antibacterial acid, key component honeysuckle, after We gained preliminary insights into extract against various bacteria, including Escherichia coli , Staphylococcus aureus Pseudomonas aeruginosa . Furthermore, analyzed extracts different concentrations liquid medium, morphology bacteria inhibition was analyzed. These findings suggest that solvent (DES) an efficient, friendly, cost‐effective method components honeysuckle. Moreover, extracted DES retain robust physiological activity.

Language: Английский

---

Optimization of Eugenol Extraction From Piper betle Leaves Using Natural Deep Eutectic Solvents and Ultrasound‐Assisted Extraction

Separation Science Plus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

ABSTRACT Piper betle L. (Piperaceae) is a herbal plant used in Thai traditional medicine for its antifungal and antiallergic properties, particularly through topical application. This study aimed to optimize the extraction of leaves using natural deep eutectic solvents enhance efficiency eugenol, active compound leaves. Various types hydrogen bond donors—including glycolic acid, lactic malic tartaric ascorbic citric acid—were combined with acceptor, choline chloride, prepare solvents. The results indicated that acid was most effective donor eugenol extraction. Subsequently, chloride:lactic molar ratios, solvent:water mass ultrasonication times were varied. Results showed optimal conditions based on one‐factor‐at‐a‐time approach ratio 1:5, 2:1, an time 30 min. Under these conditions, concentration reached 457.22 ± 21.68 µg/mL, compared 224.76 6.99 µg/mL when ethanol used. In conclusion, this successfully optimized from These findings suggest could be more solvent eugenol.

Language: Английский

---

Development of analytical method for determination of 1,3‐dimethylamylamine in sports nutrition and bodybuilding supplements using pH‐switchable deep eutectic solvents followed by high‐performance liquid chromatography‐diode array detector

Journal of Separation Science, Journal Year: 2024, Volume and Issue: 47(17)

Published: Aug. 31, 2024

In this work, an easy, safe, simple, and efficient pH‐switchable deep eutectic solvents (DESs)‐based liquid phase microextraction followed by high‐performance chromatography‐diode array detector analysis was developed for the determination of 1,3‐dimethylamylamine (DMAA). The switchability obtained DESs investigated changing pH. Then best‐selected DES characterized application selected in extraction DMAA from sports nutrition bodybuilding supplements investigated. synthesized l ‐menthol: oleic acid a molar ratio 1:2 had highest efficiency target compound. Under optimum conditions, (50 µL DES, 100 4 mol/L KOH, HCl, time 40 s without salt addition) calibration graph linear range 0.05–100 µg/kg limit detection 0.02 µg/kg. relative standard deviations including intra‐day inter‐day 10.0 real samples were 2.7% ( n = 7) 5.3% 7), respectively. enrichment factor percentage recovery method 283 85%, recoveries different 90%–109%.

Language: Английский

---

Optimization of Microwave‐Assisted Extraction of Curcuma zedoaria Rhizome: A Comparative Study of Castor Oil and Sesame Oil

Separation Science Plus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

ABSTRACT Curcuma zedoaria (Christm.) Roscoe is a curcuminoid‐rich plant with potential applications in cosmetic products. This study aimed to optimize the microwave‐assisted extraction (MAE) conditions for C. rhizomes using castor oil and sesame as solvents. A full factorial design was employed, investigating microwave power levels of 600 800 W, times 30 90 s. The results showed that time significantly affected yield, individual total curcuminoid content while did not. optimal maximizing yield were W s oil, 80 oil. Stability testing revealed curcuminoids more stable than when stored at 4°C, 30°C/75% relative humidity (RH), 40°C/75% RH over 3 months. In conclusion, this demonstrates MAE an effective method extracting from , showing superior preservation content. These findings suggest could be preferable solvent stabilization applications.

Language: Английский

---

Fatty Acid–Based pH‐Switchable Deep Eutectic Solvents for the Extraction and Preconcentration of Chlorobenzenes From Water Samples Followed by Gas Chromatography–Electron Capture Detection

Separation Science Plus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

ABSTRACT An easy, safe, simple, and efficient pH‐switchable hydrophobic deep eutectic solvent (DES)‐based liquid‐phase microextraction was developed for the extraction of chlorobenzenes (CBs) from water samples followed by a gas chromatography–electron capture detector (GC–ECD). The switchability synthesized DESs tested changing pH. DES thymol:octanoic acid (OA) in molar ratio 2:1 had highest efficiency extracting CBs samples. 1,4‐Dibromobenzene used as internal standard (IS). optimal conditions were established to be 20.0 µL thymol:OA (2:1), 100 5 mol L −1 KOH, HCl, 60 s time, without salt addition. Under optimum conditions, calibration graphs linear range 0.005–150 µg , limits detection 0.001–0.03 . relative deviations, including intraday inter‐day 5.0 dichlorobenzene isomers, 2.0 trichlorobenzene tetrachlorobenzene 0.50 pentachlorobenzene hexachlorobenzene isomers with using IS, 0.6%–3.2% ( n = 7) 3.8%–6.7% 7), respectively. accuracies, intraday, 93.5%–106.3% 91.7%–109.4%,

Language: Английский

---