Nucleus‐Spike 3D Hierarchical Superstructures via a Lecithin‐Mediated Biomineralization Approach DOI Open Access

Jiaxin Rui,

Tingting Wu, Zhiwei Zhang

et al.

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract 3D hierarchical superstructures (3DHSs) are key products of nature's evolution and have raised wide interest. However, the preparation 3DHSs composed building blocks with different structures is rarely reported, regulating their structural parameters challenging. Herein, a simple lecithin‐mediated biomineralization approach reported for first time to prepare gold 0D nucleus 1D protruding dendritic spikes. It demonstrated that hydrophobic complex by coordination disulfiram (DSF) share chloroauric acid forming 3DHSs. Under lecithin mediation, reduced form nucleus, followed spike growth through reduction complex. The prepared possess well‐defined morphology length ≈95 nm. Notably, density systematically manipulated from 38.9% 74.3% controlling DSF concentrations. Moreover, diameter regulated 9.2 12.9 nm selecting concentrations tune process. Finite‐difference time‐domain (FDTD) simulations reveal spikes “hot spots”. dense structure endows sound performance in surface‐enhanced Raman scattering (SERS) applications.

Language: Английский

Dual-Shell Nanocomposites for Enhanced Therapeutic Applications in Cancer Treatment DOI

Zhaoguo Wu,

Xuezhi Zhou, Aiwu Zhao

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: 8(5), P. 2280 - 2290

Published: Jan. 24, 2025

A combination of endoskeleton and exoskeleton in a dual shell has been considered for simultaneously improving the core–satellite binding efficiency stability. two-step preassembling-postgrowth approach fabricating stimulus-responsive core–shell–satellite–shell (CSSS) nanocomposites. CSSS therapeutic nanosystem designed controllable release drug situ monitoring chemotherapy via mode. Incorporation bifunctional SH-PNIPAM-COOH (TPNIC) nanocomposites plays role cross-linking core–satellites Raman enhancement. On one hand, TPNIC swelling status can act as cross-linker assembling Au satellites on PFe3O4 (PEI-functionalized Fe3O4) core. other adjust alteration temperature; moreover, it induces optical hot-spot generation giving coupling plasmonic effect to produce much stronger SERS performance than simple assembling. Thus, collapse layer above lower critical solution temperature (LCST) be adopted enhanced chemotherapeutics releasing doxorubicin tumor microenvironment (TME). The contribute delivering anticancer efficiently penetrating cell membrane retarding TME. obvious advantages are its facile magnetic recycling regeneration so realize sustainable tumor.

Language: Английский

Citations

0
Nucleus‐Spike 3D Hierarchical Superstructures via a Lecithin‐Mediated Biomineralization Approach DOI Open Access

Jiaxin Rui,

Tingting Wu, Zhiwei Zhang

et al.

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract 3D hierarchical superstructures (3DHSs) are key products of nature's evolution and have raised wide interest. However, the preparation 3DHSs composed building blocks with different structures is rarely reported, regulating their structural parameters challenging. Herein, a simple lecithin‐mediated biomineralization approach reported for first time to prepare gold 0D nucleus 1D protruding dendritic spikes. It demonstrated that hydrophobic complex by coordination disulfiram (DSF) share chloroauric acid forming 3DHSs. Under lecithin mediation, reduced form nucleus, followed spike growth through reduction complex. The prepared possess well‐defined morphology length ≈95 nm. Notably, density systematically manipulated from 38.9% 74.3% controlling DSF concentrations. Moreover, diameter regulated 9.2 12.9 nm selecting concentrations tune process. Finite‐difference time‐domain (FDTD) simulations reveal spikes “hot spots”. dense structure endows sound performance in surface‐enhanced Raman scattering (SERS) applications.

Language: Английский

Citations

0