Optimized Synthesis of Biphasic Calcium Phosphate: Enhancing Bone Regeneration with Tailored β-tricalcium Phosphate/ Hydroxyapatite Ratio DOI
Dieu Linh Tran, Qui Thanh Hoai Ta, Manh Hoang Tran

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Biphasic calcium phosphate (BCP) is a bioceramic widely used in hard tissue engineering for bone replacement. BCP consists of β-tricalcium (β-TCP) - highly soluble and resorbable phase hydroxyapatite (HA) stable phase, creating balance between solubility resorption, optimally supporting cell interactions growth. The β-TCP/HA ratio significantly affects the solubility, cellular response, with higher β-TCP increasing resorption due to its solubility. commonly synthesized by calcining calcium-deficient apatite (CDA) at temperatures above 700 °C via direct or indirect methods. This study investigated effects pH sintering temperature on wet precipitation, aiming achieve an 80/20 ratio, which known be optimal regeneration. By maintaining constant Ca/P precursor 1.533, conditions were determined 5.5-6 900 °C, chosen material stability successful synthesis was confirmed using X-ray diffraction (XRD) Fourier transform infrared (FTIR) spectroscopy. At same time, material's physical chemical properties further characterized through scanning electron microscopy (SEM) degradation studies simulated body fluid (SBF). In vitro tests demonstrated excellent cytocompatibility osteogenic differentiation, while vivo rabbit femur defects significant regeneration, bone-to-tissue volume ratios exceeding 50% within four weeks. These results highlight potential BCPs biomaterials research.

Language: Английский

Optimized Synthesis of Biphasic Calcium Phosphate: Enhancing Bone Regeneration with Tailored β-tricalcium Phosphate/ Hydroxyapatite Ratio DOI
Dieu Linh Tran, Qui Thanh Hoai Ta, Manh Hoang Tran

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Biphasic calcium phosphate (BCP) is a bioceramic widely used in hard tissue engineering for bone replacement. BCP consists of β-tricalcium (β-TCP) - highly soluble and resorbable phase hydroxyapatite (HA) stable phase, creating balance between solubility resorption, optimally supporting cell interactions growth. The β-TCP/HA ratio significantly affects the solubility, cellular response, with higher β-TCP increasing resorption due to its solubility. commonly synthesized by calcining calcium-deficient apatite (CDA) at temperatures above 700 °C via direct or indirect methods. This study investigated effects pH sintering temperature on wet precipitation, aiming achieve an 80/20 ratio, which known be optimal regeneration. By maintaining constant Ca/P precursor 1.533, conditions were determined 5.5-6 900 °C, chosen material stability successful synthesis was confirmed using X-ray diffraction (XRD) Fourier transform infrared (FTIR) spectroscopy. At same time, material's physical chemical properties further characterized through scanning electron microscopy (SEM) degradation studies simulated body fluid (SBF). In vitro tests demonstrated excellent cytocompatibility osteogenic differentiation, while vivo rabbit femur defects significant regeneration, bone-to-tissue volume ratios exceeding 50% within four weeks. These results highlight potential BCPs biomaterials research.

Language: Английский

Citations

0