Harnessing Competitive Interactions to Regulate Supramolecular “Micelle-Droplet-Fiber” Transition and Reversibility in Water

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(43), P. 29759 - 29766

Published: Oct. 15, 2024

The supramolecular assembly of proteins into irreversible fibrils is often associated with diseases in which aberrant phase transitions occur. Due to the complexity biological systems and their surrounding environments, mechanism underlying separation-mediated poorly understood, making reversal so-called fibrillization a significant challenge. Therefore, it crucial develop simple model that provide insights mechanistic process monomers phase-separated droplets ordered assemblies. Such models can help investigating strategies either reverse or modulate these states. Herein, we present synthetic system composed three components, including benzene-1,3,5-tricarboxamide-based monomer, surfactant, water, mimic condensate pathway observed systems. This highly dynamic undergo "micelle-droplet-fiber" transition over time space concentration gradient field, regulated by competitive interactions. Importantly, manipulating interactions through guest molecules, temperature changes, cosolvents fibers disordered liquid micellar state. Our provides new critical balance between various among components determine reversibility process. Extending this "competitive interaction" approach from complex macromolecules, e.g., proteins, could open avenues for biomedical applications, such as condensate-modifying therapeutics.

Language: Английский

Harnessing competitive interactions to regulate supramolecular “micelle-droplet-fiber” transition and reversibility in water

Published: Aug. 16, 2024

Supramolecular assembly of proteins into irreversible fibrils is often associated with diseases where aberrant phase transitions occur. Due to the complexity biological systems and their surrounding environments, mechanism underlying separation-mediated supramolecular poorly understood, making reversal so-called fibrillization a significant challenge. Therefore, it crucial develop simple model that provide insights mechanistic process monomers phase-separated droplets ordered assemblies. Such models can help in investigating strategies either reverse or modulate these states. Herein, we present synthetic system composed three components, including benzene-1,3,5-tricarboxamide-based monomer, surfactant, water, mimic condensate pathway observed systems. This highly dynamic undergo “micelle-droplet-fiber” transition over time space gradient field, regulated by competitive interactions. Importantly, manipulating interactions through guest molecules, temperature changes, co-solvent fibers back disordered liquid micellar state. Our provides new critical balance between various among components determine reversibility process. Extending this ‘competitive-interactions’ approach from complex macromolecules, e.g., proteins, could open avenues for biomedical applications, such as condensate-modifying therapeutics.

Language: Английский

Bioinspired programmable coacervate droplets and self-assembled fibers through pH regulation of monomers

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Demonstration of transient coacervate droplets and programmable fibers was achieved by temporally regulating the pH solution through biocatalytic modulation.

Language: Английский