Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(75), P. 10394 - 10397
Published: Jan. 1, 2024
Compounds
comprising
S-S
bonds
serve
as
significant
pharmacological
scaffolds
in
medicinal
chemistry
and
natural
products.
We
have
devised
an
efficient
electrochemical
method
for
the
construction
of
asymmetric
disulfide
bonds,
leading
to
synthesis
unsymmetric
thiosulfonates.
Compared
with
existing
methods,
our
work
not
only
avoids
use
metals
oxidants,
but
also
realizes
operation
a
one-pot
three-component
method,
which
makes
this
strategy
extremely
attractive.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(7), P. 4912 - 4917
Published: Feb. 18, 2022
Herein,
an
unprecedented
electrochemical
approach
for
the
synthesis
of
α-keto
acetals
has
been
established
from
readily
available
terminal
alkynes
and
alcohols.
By
merging
organoselenium-catalyzed
processes,
desired
products
are
obtained
at
room
temperature
in
absence
basic
or
metallic
additives,
with
carbonyl
acetal
motifs
incorporated
simultaneously
across
triple
bonds
a
single
operation.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(6), P. 1274 - 1279
Published: Feb. 3, 2022
An
efficient
synthetic
route
for
the
construction
of
N2-aryl
1,2,3-triazoles
is
reported
via
sequential
C-N
bond
formation
and
electro-oxidative
N-N
coupling
under
metal-free
conditions.
Readily
accessible
2-aminoacrylates
aryldiazonium
salts
were
used
as
starting
materials,
developed
protocol
displays
excellent
functional
group
tolerance,
allowing
an
extensive
range
substrate
scope
up
to
91%
isolated
yield.
Various
mechanistic
studies,
along
with
isolation
intermediate
adduct,
refer
successive
ionic
radical
reaction
sequences.
ChemElectroChem,
Journal Year:
2024,
Volume and Issue:
11(17)
Published: Aug. 12, 2024
Abstract
Electrochemistry
became
a
unique
and
powerful
tool
for
the
preparation
of
plethora
valuable
chemical
species
including
functional
materials,
drug
candidates
clinically
approved
pharmaceuticals.
Organic
electrosynthesis
well
satisfies
main
goals
green
chemistry
development
is
considered
as
one
useful
approaches
toward
creation
sustainable
future.
Since
nitrogen
heterocyclic
scaffolds
still
retain
their
importance
construction
novel
materials
medications,
emerging
trends
in
organic
electrochemistry
discovery
synthetic
methods
assembly
subunits.
In
this
regard,
provides
an
efficient
platform
environmentally
benign
generation
various
nitrogen‐centered
radicals
which
are
prominent
intermediates
synthesis
heterocycles.
Review,
recent
developments
heterocycles
via
electrochemical
summarized.
The
special
emphasis
devoted
to
influence
solvent,
electrodes
electrolytes
on
step,
since
these
crucial
parameters
regulate
process
efficiency.
Chemical Science,
Journal Year:
2021,
Volume and Issue:
12(43), P. 14343 - 14352
Published: Jan. 1, 2021
For
more
than
a
century,
the
dehydrogenative
formation
of
N–N
bonds
has
remained
mostly
confidential.
Several
cross-dehydrogenative
coupling
methods
have
appeared
recently,
promising
soon
to
come
broad
applicability
concept.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2022,
Volume and Issue:
10(31), P. 10294 - 10302
Published: July 27, 2022
Synthetic
photoelectrochemistry
shows
significant
advantages
in
handling
of
reactive
intermediates
via
a
sustainable
way
and
has
developed
to
be
the
frontier
single
electron
transfer
chemistry.
The
exploration
new
photoelectrocatalysts,
especially
uncommon
metal-based
ones,
will
contribute
exploitation
synthetic
strategies.
Benefiting
from
reversible
redox
ability
photoactivity,
cerium
salt
is
expected
become
photo-electro-response
medium
generate
active
species.
In
this
work,
with
green
reaction
system
(neutral
conditions
renewable
light
electricity
as
energy
sources),
we
novel
type
generation
Cl·
electrooxidation
photoinduced
ligand-to-metal
charge
by
using
CeCl3
photoelectrocatalyst
oxydichlorination
aryl
acetylene.
Importantly,
found
that
slow
releasing
chloride
ions
chlorine
radicals
played
an
important
role
radical
chlorination.
addition,
several
analytical
methods
including
cyclic
voltammetry,
X-ray
photoelectron
spectroscopy,
paramagnetic
resonance,
control
experiments
were
conducted
investigate
reasonable
mechanism.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(5), P. 1283 - 1288
Published: Jan. 1, 2023
An
environmentally
friendly
electrochemical
fluorotrifluoromethylation
of
styrenes
is
developed
using
CF
3
SO
2
Na
and
Et
N·3HF
as
the
F-containing
donor
reagents.
This
synthetic
strategy
features
step
economy
sustainability.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(17), P. 11656 - 11668
Published: Aug. 12, 2022
Using
phenyliodine
diacetate
as
an
oxidant
and
nickel
acetate
a
promoter,
wide
range
of
unsymmetric
thiosulfonates
could
be
furnished
easily
in
moderate
to
excellent
yields
starting
from
N-substituted
O-thiocarbamates
sodium
sulfinates.
This
protocol
features
mild
conditions,
short
reaction
times,
high
atomic
utilization,
which
can
provide
alternative
method
for
the
synthesis
thiosulfonates.
In
addition,
scaled
up
on
gram
scale,
showing
potential
application
value
industry.
