Anchoring silver nanoparticles on graphene quantum dots: A highly efficient, green, and rapid nano-catalyst for the reduction of nitro compounds and tandem reductive Ugi reactions
Saeed Torabi,
No information about this author
Tahereh Nasiriani,
No information about this author
Siamak Javanbakht
No information about this author
et al.
Journal of Physics and Chemistry of Solids,
Journal Year:
2025,
Volume and Issue:
unknown, P. 112633 - 112633
Published: Feb. 1, 2025
Language: Английский
Fluorinated Sulfonamides: Synthesis, Characterization, In Silico, Molecular Docking, ADME, DFT Predictions, and Structure‐Activity Relationships, as Well as Assessments of Antimicrobial and Antioxidant Activities
Mohamed Ahmed Mahmoud Abdel Reheim,
No information about this author
Basma Ghazal,
No information about this author
Sayeda A. Abdelhamid
No information about this author
et al.
Drug Development Research,
Journal Year:
2024,
Volume and Issue:
85(8)
Published: Dec. 1, 2024
ABSTRACT
The
design
and
synthesis
of
unique
two
series
fluorinated
sulfonamides
3a‐f
5a‐g
utilizing
nucleophilic
aromatic
substitution
reactions
tetrafluorophthalonitrile
1
with
various
2
under
a
variety
different
conditions
were
the
key
goals
current
research.
chemical
composition
generated
products
has
been
investigated
via
mass
spectroscopy,
HNMR,
13
CNMR,
infrared,
elemental
analyzes.
Antimicrobial
studies
conducted
in
vitro
to
evaluate
activity
all
new
synthesized
compounds
against
resistant
strains.
first
showed
high
potency
very
low
concentrations.
All
studied
DPPH
Radical
Scavenging
Activity
other
even
molar
ratio.
In
silico
molecular
docking
was
used
investigate
potential
binding
pathways
for
receptors:
dihydroprotien
synthase
protein
(ID
Code:
1AJ0)
as
an
antibacterial
EGFR
WT
co‐crystallized
erlotinib
[PDB
ID
code
1m17].
Furthermore,
good
ADME
predictions
Lipinski
rule
five
demonstrated
that
recently
had
drug‐likeness
qualities
when
physicochemical
parameter
most
powerful
novel
candidates
determined.
Moreover,
DFT/B3LYP
method
functionalized
6‐31G
(d,
p)
basis
set
employed
calculate
quantum
parameters,
MEP
analysis,
HUMO,
LUMO.
Language: Английский
Attempts on Fluorinative Transformation of Selected Functionalized Cycloalkene Scaffolds through Aziridination/Aziridine-Opening Protocol
Melinda Nonn,
No information about this author
Lóránd Kiss,
No information about this author
Tamás T. Novák
No information about this author
et al.
Synlett,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 24, 2024
Abstract
Studies
on
the
transformations
of
some
functionalized
cycloalkene
derivatives
through
their
ring
olefin-bond
aziridination/aziridine
opening
with
fluoride
are
presented.
The
selected
model
compounds
submitted
to
fluorinative
functionalization
were
an
amino
ester
and
diesters
a
cyclohexene
skeleton
as
well
cyclopentene-fused
β-lactam.
Functionalization
proceeded
across
substrate-directed
diastereoselective
aziridination,
followed
by
fluoride-mediated
aziridine
or
intramolecular
lactonization
giving
fluorinated
lactone
derivatives.
Language: Английский
Recent Advances on the Synthesis and Application of α,α-Difluoro-β-aminophosphonates
Youlong Du,
No information about this author
Qian Wang,
No information about this author
Haibo Mei
No information about this author
et al.
Chinese Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
44(12), P. 3686 - 3686
Published: Jan. 1, 2024
Language: Английский
Domino Reactions with Dicyanoalkenes and Fluorinated Conjugated Sulfinyl Imines. A Convenient Strategy for the Generation of Structural Diversity
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
366(4), P. 970 - 981
Published: Nov. 13, 2023
Abstract
Dicyanoalkenes
are
versatile
reagents
in
organic
synthesis
and
they
have
been
extensively
used
a
wide
variety
of
transformations.
However,
their
reactivity
towards
fluorinated
imines
remained
almost
unnoticed.
The
divergent
conjugated
sulfinyl
with
dicyanoalkenes
is
described
herein.
On
the
one
hand,
when
tert
‐butyl
were
employed,
cycloaromatization
cascade
process
took
place
preferentially,
rendering
valuable
trifluoromethyl
arenes.
other
reaction
p
‐tolyl
mainly
led
to
complex
tetracyclic
skeleton,
involving
an
azetidinimine
rearrangement
intermediate.
Finally,
1‐indanone‐derived
aromatization
was
interrupted,
new
family
diene
derivatives.
Theoretical
calculations
performed
order
shed
light
on
mechanistic
outcome
this
transformation.
Language: Английский