Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(41), P. 8832 - 8836
Published: Oct. 9, 2024
A
nickel-catalyzed
tandem
alkoxylation/claisen
rearrangement
strategy
for
the
oxy-difluoroallylation
of
ynamides
has
been
developed.
In
this
reaction,
3,3-difluoroallyl
alcohol
was
used
as
a
fluorine-containing
building
block
to
construct
C–CF2
bond
first
time.
This
approach
is
recognized
its
robust
tolerance
functional
groups,
impressive
yields,
and
excellent
atomic
efficiency,
all
achieved
under
mild
reaction
conditions.
series
β,β-difluoromethyleneamide
derivatives
were
efficiently
obtained
through
simple
operations,
their
practicality
confirmed
gram-scale
synthesis
product
derivatization.
JACS Au,
Journal Year:
2025,
Volume and Issue:
5(2), P. 1031 - 1038
Published: Jan. 23, 2025
A
primary
explosive
is
a
perfect
chemical
compound
for
starting
ignition
in
military
and
commercial
uses.
Over
the
past
century,
quest
lead-free,
environmentally
friendly
explosives
has
been
significant
challenge
long-standing
goal.
Here,
an
innovative
organic
explosive,
(E)-1,2-bis(3-azido-5-(trifluoromethyl)-4H-1,2,4-triazol-4-yl)diazene
(4),
designed
synthesized
through
straightforward
three-step
reaction
from
commercially
available
reagents.
Importantly,
this
integrated
two
trifluoromethyl
azido
groups
into
N,N′-azo-1,2,4-triazole
backbone
to
enhance
performance
safety.
With
combination,
it
meets
stringent
criteria
safer,
explosives:
being
metal
perchlorate-free,
possessing
high
density,
excellent
priming
ability,
unique
sensitivities
nonexplosive
stimuli.
It
shows
robust
environmental
resistance,
good
thermal
stability,
effective
detonation
also
can
be
effectively
initiated
with
laser.
Moreover,
test,
4
successfully
detonated
500
mg
of
PETN
ultralow
minimum
primer
charge
(MPC)
40
mg,
similar
traditional
LA
(MPC:
mg)
outperforming
metal-free
ICM-103
60
DDNP
70
mg).
The
power,
combined
its
synthesis,
cost-effectiveness,
easy
large-scale
manufacturing,
makes
superior
alternative
currently
used
such
as
lead
azide
(LA)
diazodinitrophenol
(DDNP).
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(3), P. 1806 - 1812
Published: Jan. 9, 2024
Controllable
fluorocarbon
chain
elongation
(CFCE)
is
a
promising
yet
underdeveloped
strategy
for
the
well-defined
synthesis
of
structurally
novel
polyfluorinated
compounds.
Herein,
direct
and
efficient
trifluorovinylation
pentafluorocyclopropylation
aldehydes
are
described
by
using
TMSCF
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(19), P. 4037 - 4042
Published: May 8, 2024
A
novel
phosphine-catalyzed
domino
annulation
reaction
of
γ-vinyl
allenoates
and
o-aminotrifluoacetophenones
for
the
construction
terahydrofuro[3,2-c]quinoline
derivatives
has
been
developed.
In
this
reaction,
two
kinds
compounds
containing
CF3
groups
were
obtained
with
good
yields
under
mild
conditions,
three
new
C–N,
C–C,
C–O
bonds
can
be
built
in
one
step,
selectivity
is
achieved
by
adjusting
conditions.
Furthermore,
preliminary
studies
on
an
asymmetric
variant
proceeded
moderate
enantioselectivity.
Chemical Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
In
this
study,
we
explore
the
potential
of
difluoro(trifluoromethoxy)methyl
group,
CF
2
–O–CF
3
,
an
underexplored
but
promising
structural
analog
trifluoromethoxy
group
(OCF
).
The Journal of Physical Chemistry A,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
F-containing
explosives
with
additional
F
atoms
compared
to
traditional
CHON
ones
should
contain
a
more
complex
decomposition
mechanism.
Nevertheless,
understanding
the
mechanism
and
effect
of
groups
on
stability
remains
limited.
This
study
investigates
thermal
mechanisms
two
typical
compounds,
3,3,7,7-tetrakis(difluoramino)-octahydro-1,5-dinitro-1,5-diazocine
(HNFX)
1,3,5-trinitro-2,2-bis(trifluoromethyl)-1,3,5-triazinane
(TNBFT),
using
ground-state
ab
initio
molecular
dynamics
simulations
compares
them
RDX.
The
results
show
that
HNFX
decomposes
from
partition
–NF2
form
NF3
HF
at
1500
K
above
2000
K,
respectively,
while
TNBFT
undergoes
concerted
H
transfer
HONO
elimination
N–NO2
bond
cleavage
relatively
high
temperatures.
Additionally,
fluorocarbons,
as
primary
fluorinated
products,
lower
yields
H2O
CO2
RDX,
but
they
can
act
oxidizers
in
combustion
Al
particles.
Moreover,
it
is
found
significantly
weaken
bonds
nearby
total
stability.
Based
our
strength
analysis
simulation
results,
reported
experimental
confirmation
may
be
questionable.
insight
expected
deepen
guide
design
high-performance
composites
thereof.
