Difluorocarbene-Enabled Trifluoromethylation and Cyclization for the Synthesis of 3-(Trifluoromethyl)-4H-pyrans
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 27, 2024
A
three-component
annulation
reaction
and
trifluoromethylation
for
the
construction
of
3-(trifluoromethyl)-4
Language: Английский
Efficiently nucleophilic trifluoromethylation of aldehydes over MgSO4/ZrO2 catalyst
Molecular Catalysis,
Journal Year:
2024,
Volume and Issue:
556, P. 113948 - 113948
Published: Feb. 16, 2024
Language: Английский
Efficient Trifluoromethylation of Halogenated Hydrocarbons Using Novel [(bpy)Cu(O2CCF2SO2F)2] Reagent
Xiong Wu,
No information about this author
Xin Qiu,
No information about this author
Wenrun Lou
No information about this author
et al.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(12), P. 2849 - 2849
Published: June 14, 2024
This
study
introduces
a
novel
trifluoromethylating
reagent,
[(bpy)Cu(O2CCF2SO2F)2],
notable
for
not
only
its
practical
synthesis
from
cost-effective
starting
materials
and
scalability
but
also
nonhygroscopic
nature.
The
reagent
demonstrates
high
efficiency
in
facilitating
trifluoromethylation
reactions
with
various
halogenated
hydrocarbons,
yielding
products
good
yields
exhibiting
broad
functional
group
compatibility.
development
of
[(bpy)Cu(O2CCF2SO2F)2]
represents
an
advancement
the
field
organic
synthesis,
potentially
serving
as
valuable
addition
to
arsenal
existing
agents.
Language: Английский
A Continuous Flow Process for the Defluorosilylation of HFC-23 and HFO-1234yf
S Patrick,
No information about this author
James A. Bull,
No information about this author
Philip L. Miller
No information about this author
et al.
Published: Aug. 30, 2024
A
continuous
flow
process
has
been
developed
for
the
defluorosilylation
of
trifluoromethane
(HFC-23)
and
2,3,3,3-propene
(HFO-1234yf)
through
reaction
with
lithium
silanide
reagents
under
inert
conditions.
Design
experiment
optimization
improved
conditions
including
productivity,
yields,
reduction
solvent
use,
gas
destruction.
The
small
chain
fluorinated
organosilane
products
R3SiCF2H
R3SiCH2C(F)=CF2
were
competent
nucleophiles
in
fluoride-catalyzed
difluoromethylation
aldehydes,
trifluoroallylation
ketones,
imines.
Stepwise
treatment
KHMDS
IPrCuCl
gave
IPrCuCC–CF2H,
which
reacted
allyl
acyl
halides
to
transfer
propyne
motif.
Language: Английский
A Continuous Flow Process for the Defluorosilylation of HFC-23 and HFO-1234yf
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 1, 2024
A
continuous
flow
process
has
been
developed
for
the
defluorosilylation
of
trifluoromethane
(HFC-23)
and
2,3,3,3-tetrafluoropropene
(HFO-1234yf)
through
reaction
with
lithium
silanide
reagents
under
inert
conditions.
Design
experiment
optimization
improved
conditions,
including
productivity,
yields,
reduction
solvent
use,
gas
destruction.
The
small
chain
fluorinated
organosilane
products
R
Language: Английский
Flow Chemistry of Metal Carbenoid Species towards Selective Organic Synthesis
Synthesis,
Journal Year:
2024,
Volume and Issue:
56(18), P. 2899 - 2908
Published: April 9, 2024
Abstract
This
review
deals
with
C1
carbenoid
chemistry,
a
focus
on
lithium
species
generated
in
flash
flow
systems.
Strict
control
of
the
temperature,
residence
time,
and
mixing
efficiency
has
led
to
various
transformation
reactions
involving
epoxidation,
cyclopropanation,
homologation,
among
others.
The
use
other
metal
species,
including
trifluoromethylpotassium
(CF3K)
magnesium/
zinc
carbenoids,
systems
is
also
introduced.
1
Introduction
1.1
Lithium
Carbenoids
Chemistry
1.2
Flow
for
2
Reactions
Involving
Carbenoid
Species
2.1
Deprotonative
Generation
2.2
via
Halogen–Lithium
Exchange
2.3
Reductive
Lithiation
2.4
Alkyllithiation
2.5
Trifluoromethylpotassium
2.6
Other
Metal
3
Conclusion
Language: Английский