Visible-Light-Mediated Decarboxylative (Amino)Alkylation of Azomethine Imines DOI

Seshadri Reddy Nasireddy,

Parashuram Sharma,

Kirti Khanna

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Herein, we report an efficient, organophotocatalyzed decarboxylative (amino)alkylation of azomethine imines using readily available carboxylic acids as alkylating agents. This transformation exhibits wide scope, and a variety acids, including glycine derivatives, were employed radical precursors. The use 4CzIPN the photocatalyst allowed application nonbenzylic secondary tertiary also, overcoming previous limitations. applicability nonprefunctionalized precursors, mild conditions are highlights this method. intermediacy key intermediates was established by trapping experiments.

Language: Английский

Direct C1 Homologation of Carboxylic Acids: Free Radical Approach Enabled by Acridine Catalysis DOI

Zakhar M. Rubanov,

Vitalij V. Levin, Alexander D. Dilman

et al.

Organic Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Homologation of carboxylic acids with a tosylhydrazone reagent is described. The reaction performed using dual acridine/decatungstate photocatalytic system.

Language: Английский

Citations

0
Visible-Light-Mediated Decarboxylative (Amino)Alkylation of Azomethine Imines DOI

Seshadri Reddy Nasireddy,

Parashuram Sharma,

Kirti Khanna

et al.

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Herein, we report an efficient, organophotocatalyzed decarboxylative (amino)alkylation of azomethine imines using readily available carboxylic acids as alkylating agents. This transformation exhibits wide scope, and a variety acids, including glycine derivatives, were employed radical precursors. The use 4CzIPN the photocatalyst allowed application nonbenzylic secondary tertiary also, overcoming previous limitations. applicability nonprefunctionalized precursors, mild conditions are highlights this method. intermediacy key intermediates was established by trapping experiments.

Language: Английский

Citations

0