Hesperidin has a protective effect on paclitaxel-induced testicular toxicity through regulating oxidative stress, apoptosis, inflammation and endoplasmic reticulum stress

Reproductive Toxicology, Journal Year: 2023, Volume and Issue: 118, P. 108369 - 108369

Published: March 24, 2023

Language: Английский

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Zingerone reduces sodium arsenite-induced nephrotoxicity by regulating oxidative stress, inflammation, apoptosis and histopathological changes

Chemico-Biological Interactions, Journal Year: 2023, Volume and Issue: 374, P. 110410 - 110410

Published: Feb. 22, 2023

Language: Английский

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Beneficial effects of Chrysin on Cadmium‐induced nephrotoxicity in rats: Modulating the levels of Nrf2/HO‐1, RAGE/NLRP3, and Caspase-3/Bax/Bcl-2 signaling pathways

Gene, Journal Year: 2023, Volume and Issue: 875, P. 147502 - 147502

Published: May 22, 2023

Language: Английский

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Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2/HO-1 and caspase-3/Bax/Bcl-2 signaling pathways

Chemico-Biological Interactions, Journal Year: 2022, Volume and Issue: 365, P. 110073 - 110073

Published: July 31, 2022

Language: Английский

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Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy

Molecular Biology Reports, Journal Year: 2022, Volume and Issue: 49(7), P. 6063 - 6074

Published: March 29, 2022

Language: Английский

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Avermectin induces carp neurotoxicity by mediating blood-brain barrier dysfunction, oxidative stress, inflammation, and apoptosis through PI3K/Akt and NF-κB pathways

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 243, P. 113961 - 113961

Published: Aug. 12, 2022

Avermectin, a "low toxicity insecticide", has been widely used in recent years, but its non-target toxicity, especially to aquatic organisms, neglected. In this study, we evaluated the neurotoxic effects of avermectin on carp by establishing 96 h acute test, and possible mechanism was discussed. The LC50 found be 24.04 μg/L. Therefore, 3.005 μg/L 12.02 were as low-dose high-dose groups, respectively, investigate carp. results high-performance liquid chromatography (HPLC) analysis showed that accumulated brain. Histopathological observation immunohistochemical (IHC) TNF-α Bax exposure led inflammatory cell infiltration neuronal necrosis. mRNA levels tight junction genes IHC ZO-1 Occludin structure blood-brain barrier (BBB) destroyed. Biochemical induced accumulation MDA brain decreased activity antioxidant enzymes CAT SOD, leading oxidative stress. addition, induces inflammation activating NF-κB pathway releasing factors IL-1β, IL-6, iNOS. TEM TUNEL assays apoptosis what is more, expression apoptosis-related proteins suggested avermectin-induced may associated with inhibition PI3K/Akt signaling pathway. This study also activation partially dependent upstream concludes can induce neurotoxicity disrupting generating stress, inflammation, pathways are involved process.

Language: Английский

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Microplastics Exacerbate Cadmium-Induced Kidney Injury by Enhancing Oxidative Stress, Autophagy, Apoptosis, and Fibrosis

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(22), P. 14411 - 14411

Published: Nov. 19, 2022

Cadmium (Cd) is a potential pathogenic factor in the urinary system that associated with various kidney diseases. Microplastics (MPs), comprising of plastic particles less than 5 mm diameter, are major carrier contaminants. We applied 10 mg/L particle μm MPs and 50 CdCl2 water for three months vivo assay to assess damaging effects Cd exposure on kidney. In tests showed exacerbated Cd-induced injury. addition, involvement oxidative stress, autophagy, apoptosis, fibrosis mouse kidneys were investigated. The results aggravated injury by enhancing fibrosis. These findings provide new insights into toxic

Language: Английский

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Carvacrol reduces abnormal and dead sperm counts by attenuating sodium arsenite‐induced oxidative stress, inflammation, apoptosis, and autophagy in the testicular tissues of rats

Environmental Toxicology, Journal Year: 2023, Volume and Issue: 38(6), P. 1265 - 1276

Published: March 6, 2023

Arsenic (As) is a highly toxic metalloid. Carvacrol (CAR) the active ingredient of Lamiaceae plants and has various biological pharmacological properties. The present study investigated protective effects carvacrol against testicular toxicity induced by sodium arsenite (SA). Rats were given SA (10 mg/kg) and/or CAR (25 or 50 for 14 days. Semen analyzes showed that increased sperm motility decreased percentage abnormal dead sperm. It was determined oxidative stress with increase Nrf-2 HO-1 expressions, SOD, CAT, GPx, GSH levels, MDA levels after treatment. observed autophagy inflammation triggered in tissue alleviated suppressing expressions LC3A, LC3B, MAPK-14, NF-κB, TNF-α, IL-1β, iNOS, COX-2 biomarkers rats CAR. Also, treatment suppressed SA-induced apoptosis inhibiting Bax Caspase-3 testicles up-regulating Bcl-2 expression. Histopathological had deterioration tubule structure spermatogenesis cell line, especially serious loss spermatogonia cells, atrophy seminiferous tubules, germinal epithelium. In group CAR, epithelium connective normal morphological an diameters observed. As result, it stress, inflammation, autophagy, thus protecting from damage increasing semen quality.

Language: Английский

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Contribution of Oxidative Stress, Apoptosis, Endoplasmic Reticulum Stress and Autophagy Pathways to the Ameliorative Effects of Hesperidin in NaF‐Induced Testicular Toxicity

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 20(3)

Published: Feb. 20, 2023

The ameliorative effects of hesperidin (HES) on the toxicities created by sodium fluoride (NaF) in testes tissue rats were studied via oxidative stress, apoptosis and endoplasmic reticulum (ER) stress pathways. animals divided into five distinct groups (7 each group). Group 1 was control group, group 2 received NaF-only (600 ppm), 3 HES-only (200 mg/kg bw); 4 NaF ppm)+HES (100 bw) 5 for 14 days. NaF-induced damage reducing activities superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPx) levels (GSH), increasing lipid peroxidation levels. treatment significantly downregulated mRNA SOD1, CAT GPx. supplementation caused upregulating p53, NFkB, caspase-3, caspase-6, caspase-9, Bax downregulating Bcl-2. Furthermore, ER transcript PERK, IRE1, ATF-6 GRP78. led to autophagy upregulation Beclin1, LC3A, LC3B AKT2. In tissue, however, co-treatment with HES at doses 100 200 reduced apoptosis, stress. Overall, findings this study suggest that may help reduce toxicity.

Language: Английский

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Protective effects of naringin on colistin‐induced damage in rat testicular tissue: Modulating the levels of Nrf‐2/HO‐1, AKT‐2/FOXO1A, Bax/Bcl2/Caspase‐3, and Beclin‐1/LC3A/LC3B signaling pathways

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(2)

Published: Jan. 21, 2024

Abstract Antimicrobial agent resistance has become a growing health issue across the world. Colistin (COL) is one of drugs used in treatment multidrug‐resistant bacteria resulting toxic effects. Naringin (NRG), natural flavonoid, come to fore as its antioxidant, anti‐inflammatory, and antiapoptotic activities. The aim present study was determine whether NRG protective effects on COL‐induced toxicity testicular tissue. Thirty‐five male Spraque rats were randomly divided into five groups ( n = 7 per group): Control, COL, NRG, COL + 50, 100. (15 mg/kg b.w., i.p., once per/day), (50 or 100 mg/kg, oral, b.w./once per/day) administered for days. parameters oxidative stress, inflammation, apoptosis, autophagic damage evaluated by using biochemical, molecular, western blot, histological methods issues. reversed increased malondialdehyde level reduced antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione) levels due administration p < 0.001), stress mitigated. Nuclear factor erythroid 2‐related factor‐2 pathway, antioxidant defence systems, stimulated 0.001). markers pathways apoptotic 0.001) damages induced COL. Sperm viability live/dead ratio but enhanced treatment. Testicular tissue integrity damaged showed tendency improve NRG. In conclusion, exhibited effect elevating autophagy, damage. demonstrated alleviating

Language: Английский

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