Reprogramming of DNA methylation patterns mediates perfluorooctane sulfonate-induced fetal cardiac dysplasia

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 919, P. 170905 - 170905

Published: Feb. 11, 2024

Language: Английский

---

Cannabidiol attenuates arsenic-induced nephrotoxicity via the NOX4 and NF-κB pathways in mice

Research in Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 19(4), P. 447 - 458

Published: July 1, 2024

Background and purpose: Cannabidiol (CBD) is a phenolic terpene compound with anticancer, antioxidant, anti-inflammatory, antibacterial, neuroprotective, anticonvulsant properties. Since the effects of CBD on sodium arsenite (As)-induced nephrotoxicity have not been fully determined, this study investigated effect As-induced by evaluating NOX4 NF-kB pathways in mice. Experimental approach: 48 male mice were divided into six groups (8 each) including group 1, receiving saline for 14 days; 2, (10 mg/kg, intraperitoneally) from 7 th to day; 3, As mg/kg) days gavage; treatment 4-6, (2.5, 5, 10 i.p.) 1.5 h before mg/kg gavage, days) day. Mice anesthetized after overnight fasting day 15, blood sample was collected their hearts. The level antioxidants pro-inflammatory factors, expression ROS TNF-α, NF-kB, NOX4, iNOS, cleaved PARP, caspase-3 proteins measured histological studies performed. Findings/Results: Exposure significantly increased kidney markers, oxidative stress, apoptosis, inflammation tissue, pretreatment reversed these changes. In addition, decreased levels factors PARP antioxidants. Conclusion implications: ameliorated related inhibiting inflammation, potentially through NF-kB/Nox4 pathway.

Language: Английский

---

Melatonin alleviates 3,3′,4,4′,5‐pentachlorobenzene induced colon injury by relieving oxidative stress

Environmental Toxicology, Journal Year: 2023, Volume and Issue: 38(12), P. 2993 - 3005

Published: Aug. 20, 2023

3,3',4,4',5-pentachlorobiphenyl (PCB126) is widely distributed, non-degradable and bioaccumulative, which can affect the function of tissues organs living organisms. Melatonin (MT) a sort indole neurohormone that mainly secreted by pineal gland. Numerous studies have shown MT alleviate intestinal injury through various mechanisms such as antioxidant, anti-inflammatory, anti-apoptosis. For above reasons, aim this study to explore mechanism in mice after exposure PCB126 well antagonistic effect MT. Mice were respectively fed (0.326 mg/kg) and/or (10 vivo. In vitro, colonic epithelial cells (MCEC) treated with (150 μM) (2 mM). We found microscopic structure colon tissue was impaired PCB126. The levels oxidative stress, protein mRNA expression inflammatory related factors significantly increased tight junction decreased. Notably, promote Nrf2/HO-1 level reduce caused Further vitro treatment reactive oxygen species inhibitors (NAC) showed it alleviated PCB126-induced MCEC cell damage. summary, results suggested alleviates inflammation inhibiting overproduction (ROS) up-regulating protein. Our contribute further comprehension toxicity effects significant role preserving injury.

Language: Английский

---

"Cannabinoids as Potential Therapeutic Agents for Kidney and Liver Toxicity: A Review"

Journal of advanced Biomedical and Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 6(4), P. 184 - 187

Published: Oct. 1, 2023

Cannabinoids have many important properties, such as anti-inflammatory, antioxidant, and neuroprotective effects that make cannabinoids promising to reduce kidney liver toxicity.There are some conditions, oxidative stress fibrosis, well inflammation, associated with nephrotoxicity hepatotoxicity.Cannabinoids showed the ability these effects.According numerous experimental investigations preclinical models, compounds appear play a part in controlling inflammation cell death by activating certain receptors regulating cellular pathways.However, assure safety effectiveness of cannabinoids, further research is required develop dose regimens comprehend medication interactions.Measurements cannabinoid optimal dosages, frequency, duration treatment need be addressed carefully.

Language: Английский

---