Recent Advances in Two-Dimensional Nanomaterials for Healthcare Monitoring

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(4), P. 1706 - 1734

Published: April 2, 2024

The development of advanced technologies for the fabrication functional nanomaterials, nanostructures, and devices has facilitated biosensors analyses. Two-dimensional (2D) with unique hierarchical structures, a high surface area, ability to be functionalized target detection at surface, exhibit potential biosensing applications. electronic properties, mechanical flexibility, optical, electrochemical, physical properties 2D nanomaterials can easily modulated, enabling construction platforms various analytes targeted recognition, sensitivity, selectivity. This review provides an overview recent advances in nanostructures used biosensor wearable-sensor healthcare health-monitoring Finally, advantages 2D-nanomaterial-based several challenges their optimal operation have been discussed facilitate smart high-performance future.

Language: Английский

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Comparison of developmental toxicity of graphene oxide and graphdiyne to zebrafish larvae

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2024, Volume and Issue: 281, P. 109924 - 109924

Published: April 13, 2024

Language: Английский

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Influences of TiO₂ nanoparticle and fipronil co‐exposure on metabolite profiles in mouse intestines

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: 44(11), P. 1793 - 1803

Published: July 29, 2024

Abstract Food contaminates, such as insecticide, may influence the toxicity of nanoparticles (NPs) to intestine. The present study investigated combined TiO 2 NPs and fipronil male mouse Juvenile mice (8 weeks) were orally exposed 5.74 mg/kg NPs, 2.5 fipronil, or both, once a day, for 5 days. We found that both induced some pathological changes in intestines, accompanying with defective autophagy, but these effects not obviously enhanced after NP co‐exposure. Fipronil promoted Ti accumulation minimal impact on other trace elements NP‐exposed intestines. Metabolomics data revealed exposure altered metabolite profiles two KEGG pathways, namely, ascorbate aldarate metabolism (mmu00053) glutathione (mmu00480), only statistically significantly changed Five metabolites, including 2‐deoxy‐D‐erythro‐pentofuranose 5‐phosphate, 5alpha‐cholestanol, beta‐D‐glucopyranuronic acid, elaidic isopentadecanoic maltotriose, more up‐regulated co‐exposure, whereas trisaccharide xylonolactone down‐regulated by concluded had enhance intestines profiles.

Language: Английский

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Epigallocatechin gallate alleviated the in vivo toxicity of ZnO nanoparticles to mouse intestine

Journal of Applied Toxicology, Journal Year: 2023, Volume and Issue: 44(5), P. 686 - 698

Published: Dec. 14, 2023

Abstract To evaluate the oral toxicity of nanoparticles (NPs), it is necessary to consider interactions between NPs and nutrient molecules. Recently, we reported that epigallocatechin gallate (EGCG), a healthy component in green tea, alleviated ZnO 3D Caco‐2 spheroids vitro. The present study investigated combined effects EGCG mice vivo. Mice were administrated with 35 or 105 mg/kg bodyweight without presence 80 via gastric route, once day, for 21 days, influences on intestine investigated. We found altered colloidal properties both water artificial juice. As expected, induced toxicological effects, such as decreased bodyweight, higher Chiu's scores, ultrastructural changes intestine, whereas these effects. Combined exposure also changed trace element levels mouse intestine. For example, Ti, Co, Ni only significantly elevated after co‐exposure NPs, Fe by NPs. Western blot analysis suggested tight junction (TJ) endoplasmic reticulum (ER) proteins but inhibited this trend. Combined, data intestinal damage, imbalance, TJ/ER protein expression

Language: Английский

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Effects of Halloysite Nanotubes and Multi-walled Carbon Nanotubes on Kruppel-like Factor 15-Mediated Downstream Events in Mouse Hearts After Intravenous Injection

Cardiovascular Toxicology, Journal Year: 2024, Volume and Issue: 24(4), P. 408 - 421

Published: Feb. 27, 2024

Language: Английский

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Investigation of oral toxicity of WS₂ nanosheets to mouse intestine: Pathological injury, trace element balance, lipid profile changes, and autophagy

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 29, 2024

Abstract The success of graphene oxides has gained extensive research interests in developing novel 2D nanomaterials (NMs). WS 2 nanosheets (NSs) are transition metal‐based NMs, but their toxicity is unclear. In this study, we investigated the oral NSs to mouse intestines. Male mice were administrated with vehicles, 1, 10, or 100 mg/kg via intragastric route, once a day, for 5 days. results indicate that did not induce pathological ultrastructural changes There minimal trace elements exposure W accumulation, and only Co levels dose‐dependently increased. Lipid droplets observed all groups mice, lipidomics data significantly decreased four lipid species, belonging phosphatidylcholine (PC). proteins regulating autophagic lipolysis, namely, LC3, lysosomal associated membrane protein (LAMP2) perilipin (PLIN2), increased, it was statistically different LC3. study suggest repeated induced influences on injury, element balance, autophagy, profiles intestines, indicating relatively high biocompatibility intestine route.

Language: Английский

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Effects of orally exposed SiO2 nanoparticles on lipid profiles in gut-liver axis of mice

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 290, P. 117580 - 117580

Published: Dec. 20, 2024

Language: Английский

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