Exosome tropism and various pathways in lung cancer metastasis

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 14, 2025

Lung cancer, characterized by its high morbidity and mortality rates, has the capability to metastasize various organs, thereby amplifying detrimental impact fatality. The metastasis of lung cancer is a complex biological phenomenon involving numerous physiological transformations. Exosomes, small membranous vesicles enriched with biologically active components, are pivotal in mediating intercellular communication regulating functions due their specificity stability. Extensive research elucidated production exosomes contexts. Multitude evidence demonstrates strong association between exosomes. Additionally, concept pre-metastatic niche crucial metastatic process facilitated This review emphasizes role on disease’s development progression other tissues. Furthermore, it explores potential as biomarkers for metastasis, offering significant insights future clinical advancements.

Language: Английский

Visfatin Facilitates VEGF-D-Induced Lymphangiogenesis through Activating HIF-1α and Suppressing miR-2277-3p in Human Chondrosarcoma

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5142 - 5142

Published: May 9, 2024

Chondrosarcoma is a malignant bone tumor that arises from abnormalities in cartilaginous tissue and associated with lung metastases. Lymphangiogenesis plays an essential role cancer metastasis. Visfatin adipokine reported to enhance metastasis, but its relationship VEGF-D generation lymphangiogenesis chondrosarcoma remains undetermined. Our results clinical samples reveal levels are markedly higher patients than normal individuals. stimulation promotes VEGF-D-dependent lymphatic endothelial cell lymphangiogenesis. We also found visfatin induces production by activating HIF-1α reducing miR-2277-3p through the Raf/MEK/ERK signaling cascade. Importantly, controls chondrosarcoma-related vivo. Therefore, promising target treatment of

Language: Английский

Genetic associations of visfatin polymorphisms with clinicopathologic characteristics of prostate cancer in Taiwanese males

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(13), P. 2494 - 2501

Published: Jan. 1, 2024

The most general cancer in men is prostate (PCa), with its risk increasing due to age and obesity. Visfatin, a member of adipokines, related progression metastasis, but relationship PCa remains undetermined. In addition, no knowledge available regarding relations between

Language: Английский