Driving research on successful aging and neuroprotection in Latin America: Insights from the inaugural symposium on brain resilience and healthy longevity
Alzheimer s & Dementia,
Journal Year:
2025,
Volume and Issue:
21(3)
Published: March 1, 2025
Abstract
INTRODUCTION
Global
life
expectancy
has
steadily
increased
in
recent
decades,
resulting
a
significant
rise
the
number
of
individuals
aged
80
years
and
older.
This
trend
is
also
evident
Latin
America,
where
improving,
though
at
varying
rates
across
countries
regions.
METHODS
Partnering
with
Neurosciences
Group
Antioquia
(GNA),
we
launched
Colombian
study
on
resilience
families
autosomal
dominant
Alzheimer's
disease
oldest‐old
population.
Over
past
2
years,
project
expanded
to
include
participants
from
Peru,
Chile,
Costa
Rica.
RESULTS
research
led
first
symposium
Brain
Resilience
Healthy
Longevity,
held
Medellín,
Colombia,
August
2024.
DISCUSSION
The
article
summarizes
key
discussions
symposium,
highlighting
most
promising
opportunities
for
brain
prevention
region
offering
recommendations
future
promote
healthy
aging
dementia‐free
communities.
Highlights
Uncovering
genetic
physiological
drivers
cognitive
resilience,
neurodegeneration
resistance,
longevity
essential
maintaining
function
as
age.
“Superagers”
cognitively
resilient
American
offer
valuable
insights
into
protection
mechanisms.
Studying
interplay
socio‐environmental
factors
understanding
improving
dementia
prevention.
inaugural
Longevity
Symposium
highlights
need
global
collaboration
uncover
that
drive
advancing
Language: Английский
New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop
Alzheimer s & Dementia Translational Research & Clinical Interventions,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Jan. 1, 2024
Abstract
INTRODUCTION
In
September
2022,
The
Jackson
Laboratory
Center
for
Alzheimer's
and
Dementia
Research
(JAX
CADR)
hosted
a
workshop
with
leading
researchers
in
the
disease
related
dementias
(ADRD)
field.
METHODS
During
workshop,
participants
brainstormed
new
directions
to
overcome
current
barriers
providing
patients
effective
ADRD
therapeutics.
outlined
specific
areas
of
focus.
Following
each
group
used
standard
literature
search
methods
provide
background
topic.
RESULTS
team
invited
experts
identified
four
key
that
can
be
collectively
addressed
make
significant
impact
field:
(1)
Prioritize
diversification
targets,
(2)
enhance
factors
promoting
resilience,
(3)
de‐risk
clinical
pipeline,
(4)
centralize
data
management.
DISCUSSION
this
report,
we
review
these
objectives
propose
innovations
expedite
therapeutic
pipelines.
Language: Английский