SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis

American Journal of Obstetrics and Gynecology, Journal Year: 2021, Volume and Issue: 226(1), P. 68 - 89.e3

Published: July 21, 2021

To examine the relationship between SARS-CoV-2 infection during pregnancy and risk for preeclampsia.

Language: Английский

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COVID-19 in pregnancy: implications for fetal brain development

Trends in Molecular Medicine, Journal Year: 2022, Volume and Issue: 28(4), P. 319 - 330

Published: Feb. 14, 2022

The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy on the developing fetal brain is poorly understood. Other antenatal infections such as influenza have been associated with adverse neurodevelopmental outcomes in offspring. Although vertical transmission has rarely observed SARS-CoV-2 to date, given potential for profound maternal immune activation (MIA), likely. Here we review evidence that and other viral can result maternal, placental, activation, ultimately offspring morbidity. Finally, highlight need cellular models development better understand short- long-term impacts next generation.

Language: Английский

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Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study

European Journal of Obstetrics & Gynecology and Reproductive Biology, Journal Year: 2022, Volume and Issue: 276, P. 161 - 167

Published: July 19, 2022

To assess perinatal outcomes for pregnancies affected by suspected or confirmed SARS-CoV-2 infection.Prospective, web-based registry. Pregnant women were invited to participate if they had infection between 1st January 2020 and 31st March 2021 the impact of on maternal including miscarriage, stillbirth, fetal growth restriction, pre-term birth transmission infant.Between April 2021, study recruited 8239 participants who SARs-CoV-2 episodes in pregnancy 2021. Maternal death 14/8197 (0.2%) participants, 176/8187 (2.2%) required ventilatory support. Pre-eclampsia 389/8189 (4.8%) eclampsia was reported 40/ 8024 (0.5%) all participants. Stillbirth 35/8187 (0.4 %) In delivering within 2 weeks delivery 21/2686 (0.8 stillbirth compared with 8/4596 (0.2 ≥ after (95 % CI 0.3-1.0). SGA 744/7696 (9.3 livebirths, FGR 360/8175 (4.4 pregnancies. Pre-term occurred 922/8066 (11.5%), majority these indicated births, 220/7987 (2.8%) experienced spontaneous births. Early neonatal deaths 11/8050 livebirths. Of neonates, 80/7993 (1.0%) tested positive SARS-CoV-2.Infection associated birth, most commonly compromise. The overall proportions not higher than expected, however there proportion significantly those infection. We suggest that clinicians' threshold should be low are concerns movements heart rate monitoring time around pre-eclampsia amongst would although we report a expected eclampsia. There appears no effect birthweight congenital malformations is uncommon. This reflects population range severity SARS-COV-2 pregnancy, generalisable whole obstetric populations.

Language: Английский

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Preeclampsia and severe acute respiratory syndrome coronavirus 2 infection: a systematic review

Journal of Hypertension, Journal Year: 2022, Volume and Issue: 40(9), P. 1629 - 1638

Published: July 22, 2022

Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of disease 2019 (COVID-19) that has rapidly spread worldwide, causing hundreds thousand deaths. Normal placentation characterized by many processes strictly regulated during pregnancy. If impaired, it can lead to gestational disorders, such as preeclampsia a multisystem disorder occurs in 2–8% pregnancies worldwide. Methods: We performed systematic search understand potential involvement SARS-CoV-2 onset using databases, PubMed and Web Science until 31 January 2022. Results: infection not only causes damage system but also infect human placenta cells impairing pivotal necessary for normal development. The inflammatory response trigged COVID-19 very similar one found suggesting possible link between Conclusion: Some studies showed affected had higher incidence compared with SARS-CoV-2-negative ones. However, increased blood pressure does allow associate hypertension common factor both conditions. At present, no diagnostic tools are available discriminate real from preeclampsia-like patients infection. Thus, new specific assure an appropriate diagnosis these patients, especially case severe disease.

Language: Английский

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Preeclampsia among women with COVID-19 during pregnancy and its impact on maternal and perinatal outcomes: Results from a national multicenter study on COVID in Brazil, the REBRACO initiative

Pregnancy Hypertension, Journal Year: 2022, Volume and Issue: 28, P. 168 - 173

Published: May 10, 2022

Language: Английский

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Immune Responses to SARS-CoV-2 in Pregnancy: Implications for the Health of the Next Generation

The Journal of Immunology, Journal Year: 2022, Volume and Issue: 209(8), P. 1465 - 1473

Published: Oct. 15, 2022

Abstract Widespread SARS-CoV-2 infection among pregnant individuals has led to a generation of fetuses exposed in utero, but the long-term impact such exposure remains unknown. Although fetal is rare, children born mothers with may be at increased risk for adverse neurodevelopmental and cardiometabolic outcomes. Fetal programming effects are likely mediated least part by maternal immune activation. In this review, we discuss recent evidence regarding prenatal on maternal, placental, response, as well implications health offspring. Extrapolating from what known about activation other contexts (e.g., obesity, HIV, influenza), review potential morbidity Based available data suggesting risk, highlight importance establishing large cohorts monitor offspring SARS-CoV-2–positive sequelae.

Language: Английский

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The coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis

Obstetrics & Gynecology Science, Journal Year: 2023, Volume and Issue: 66(4), P. 270 - 289

Published: May 17, 2023

The coronavirus disease 2019 (COVID-19) outbreak which started in December rapidly developed into a global health concern. Pregnant women are susceptible to respiratory infections and can experience adverse outcomes. This systematic review meta-analysis compared pregnancy outcomes according COVID-19 status. MEDLINE, EMBASE, Cochrane Library databases were searched for relevant articles published between 1, 2019, October 19, 2022. Main inclusion criterion was any population-based, cross-sectional, cohort, or case-control study that assessed with without laboratory-confirmed COVID-19. Sixty-nine studies including 1,606,543 pregnant (39,716 [2.4%] diagnosed COVID-19) retrieved. COVID-19-infected had higher risk of preterm birth (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.42-1.78), preeclampsia (OR, 1.41; CI, 1.30-1.53), low weight 1.52; 1.30-1.79), cesarean delivery 1.20; 1.10-1.30), stillbirth 1.71; 1.39-2.10), fetal distress 2.49; 1.54-4.03), neonatal intensive care unit admission 2.33; 1.72-3.16), perinatal mortality 1.96; 1.15-3.34), maternal 6.15; 3.74-10.10). There no significant differences total miscarriage, premature rupture membranes, postpartum hemorrhage, cholestasis, chorioamnionitis infection. demonstrates infection during lead information could aid researchers clinicians preparing another pandemic caused by newly discovered viruses. findings this may assist evidence-based counseling help manage

Language: Английский

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Maternal infection with COVID-19 and increased risk of adverse pregnancy outcomes: a meta-analysis

The Journal of Maternal-Fetal & Neonatal Medicine, Journal Year: 2022, Volume and Issue: 35(25), P. 9368 - 9375

Published: Feb. 13, 2022

Background: The Coronavirus disease 2019 (COVID-19) pandemic has become worldwide, posing particularly severe challenges. Pregnancy brings changes that might make individuals more vulnerable to this viral infection. To date, the impact of COVID-19 infection on pregnancy outcomes remains controversial.Method: We performed a meta-analysis address outcomes. searched PubMed and China National Knowledge infrastructure (CNKI) databases for related articles. odds ratio (OR) corresponding 95% confidence interval (95% CI) was used define INFECTION severity statistical heterogeneity among studies batched with Q-test I2 statistics.Results: collected 38 including 127,805 women. Our revealed pregnant women have been linked an increased risk premature birth (OR = 1.66, CI 1.41–1.96), stillbirth 1.98, 1.22–3.21), pre-eclampsia 1.46, 1.18–1.80), PROM 1.39, 1.07–1.81).Conclusions: showed increases preterm birth, stillbirth, pre-eclampsia, PROM. Screening early care intervene is important, given adverse

Language: Английский

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Impact of SARS-CoV-2 on pregnancy and neonatal outcomes: An open prospective study of pregnant women in Brazil

Clinics, Journal Year: 2022, Volume and Issue: 77, P. 100073 - 100073

Published: Jan. 1, 2022

To determine the incidence and risk of adverse obstetric neonatal outcomes according to SARS-CoV-2 infection severity in pregnant women.Open prospective study women tested for by serological molecular assays during pregnancy or delivery two hospitals Sao Paulo, Brazil from April 12, 2020, February 28, 2021. Five groups were considered analysis: C0, negative COVID-19 results no symptoms; C1, positive results, C2, with mild C3, moderate C4, severe symptoms. The association between was determined using multivariate analysis.734 eligible enrolled as follows: C0 (n = 357), C1 127), C2 174), C3 37), C4 39). following associated COVID-19: oligohydramnios (adjusted Odds Ratio [aOR] 6.18; 95% CI 1.87‒20.39), fetal distress (aOR 4.01; Confidence Interval [CI] 1.84‒8.75), preterm birth 5.51; 1.47‒20.61), longer hospital stay 1.66; 1.36‒2.02), admission intensive care unit 19.36; CI, 5.86‒63.99). All maternal 6, 15.4%, p < 0.001) 5, 12.5%, deaths most 4, 9.8%, occurred group. Moderate 6.23; 1.93‒20.13) 3.60; 1.45‒9.27). Mild 3.77; 1.56‒9.07).Adverse symptomatic status, increased disease severity.

Language: Английский

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Cardiovascular Complications of COVID-19 among Pregnant Women and Their Fetuses: A Systematic Review

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(20), P. 6194 - 6194

Published: Oct. 20, 2022

COVID-19 is a viral infectious disease leading to spectrum of clinical complications, especially cardiovascular. Evidence shows that this infection can potentially accompany worse outcome in pregnant women. Cardiovascular complications mothers and their fetuses are reported by previous studies. In systematic review, we aim investigate the cardiovascular during pregnancy fetus, according published literature. We systematically searched online databases PubMed, Scopus, Web Science, Google Scholar, using relevant keywords up April 2022. included all observational studies reporting among COVID-19-affected women fetuses. 74 containing 47582 cases. Pre-eclampsia, hypertensive disorders, cardiomyopathy, heart failure, myocardial infarction, thrombosis formation, alterations maternal-fetal Doppler patterns, maternal fetal arrhythmia were as complications. The highest incidences pre-eclampsia/eclampsia cases, studies, 69% 62%, lowest 0.5% 3%. bradycardia 20% 3%, regarding tachycardia, 5.4% 1%, respectively. SARS-CoV-2 be associated with mother, particularly pre-eclampsia failure. Moreover, cause arrhythmia.

Language: Английский

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