Computational exploration of flavonoids from the genus Knema with anti-inflammatory potential DOI Creative Commons
Abubakar Siddiq Salihu, Wan Mohd Nuzul Hakimi Wan Salleh, Tomisin Happy Ogunwa

et al.

Journal of the Serbian Chemical Society, Journal Year: 2023, Volume and Issue: 89(7-8), P. 1039 - 1051

Published: Dec. 12, 2023

Inflammation, a widespread biological process linked to various diseases, poses significant global health challenge. Recent research targeting the development of new anti-inflammatory drugs has prioritized plant-derived compounds due their cost-effectiveness and minimal side effects compared synthetic drugs. Flavonoids, polyphenolic in plants, show potential for treating inflammation-related diseases. This study evaluates antiinflammatory activity flavonoids from Knema genus, member Myristicaceae family. We focused on inhibiting two pro-inflammatory proteins, human murine interleukin-1B (IL-1) interleukin-6 (IL-6). Molecular docking ADMET prediction identified sulfuretin (?)-catechin with high binding affinity IL-6, whereas 4'-hydroxy-7-methoxyflavanone 7,2'-dihydroxy-6,8-dimethyl-4',5'-methylenedioxyflavan stably bind IL-6. interaction analyses revealed that hydrogen ??? bonds contribute interaction. Notably, these exhibited affinities comparable celecoxib. Our computational predictions support suitability as drug candidates, indicating promise natural agents capable modulating signaling pathways.

Language: Английский

Chemical Composition of Essential Oil from Knema squamulosa and its Biological Activity DOI
Dau B. Thin, B. B. Thinh

Chemistry of Natural Compounds, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

0
Crystal structure of 5,6,3′,4′,5′-pentamethoxy-flavone dihydrate, C20H24O9 DOI Creative Commons
Abubakar Siddiq Salihu, Wan Mohd Nuzul Hakimi Wan Salleh, Amalina Mohd Tajuddin

et al.

Zeitschrift für Kristallographie - New Crystal Structures, Journal Year: 2024, Volume and Issue: 239(4), P. 759 - 761

Published: June 19, 2024

Abstract C 20 H 24 O 9 , monoclinic, P 2 1 / c (no. 14), a = 9.7647(2) Å, b 7.3098(10) 27.7075(4) β 92.138(10)°, V 1976.33(6) Å 3 Z 4, R gt ( F ) 0.0479, wR ref 0.1504, T 300(2) K.

Language: Английский

Citations

0
Intermedianin, a new furofuran lignan from the leaves of Knema intermedia Warb DOI
Abubakar Siddiq Salihu, Wan Mohd Nuzul Hakimi Wan Salleh, David Barker

et al.

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: April 24, 2024

Phytochemical investigation of the leaves Knema intermedia has led to isolation a new furofuran lignan, intermedianin 1 together with five known lignans, α-cubebin 2, β-cubebin 3, bicubebin A 4, B 5, and C 6. The characterisation structural elucidation isolated compounds were established by extensive spectroscopic data analysis comparison literature data. antifungal activity was tested using broth microdilution assay, whereas microbial biofilms determined semi-quantitative static biofilm. Compound exhibited against C. albicans, lusitanae, auris, (each MIC/MFC value 250 µg/mL) increased biofilm auris (64.07 ± 3.83%) Candida lusitanae (62.90 3.41%) when treated 500 µg/mL.

Language: Английский

Citations

0
Computational exploration of flavonoids from the genus Knema with anti-inflammatory potential DOI Creative Commons
Abubakar Siddiq Salihu, Wan Mohd Nuzul Hakimi Wan Salleh, Tomisin Happy Ogunwa

et al.

Journal of the Serbian Chemical Society, Journal Year: 2023, Volume and Issue: 89(7-8), P. 1039 - 1051

Published: Dec. 12, 2023

Inflammation, a widespread biological process linked to various diseases, poses significant global health challenge. Recent research targeting the development of new anti-inflammatory drugs has prioritized plant-derived compounds due their cost-effectiveness and minimal side effects compared synthetic drugs. Flavonoids, polyphenolic in plants, show potential for treating inflammation-related diseases. This study evaluates antiinflammatory activity flavonoids from Knema genus, member Myristicaceae family. We focused on inhibiting two pro-inflammatory proteins, human murine interleukin-1B (IL-1) interleukin-6 (IL-6). Molecular docking ADMET prediction identified sulfuretin (?)-catechin with high binding affinity IL-6, whereas 4'-hydroxy-7-methoxyflavanone 7,2'-dihydroxy-6,8-dimethyl-4',5'-methylenedioxyflavan stably bind IL-6. interaction analyses revealed that hydrogen ??? bonds contribute interaction. Notably, these exhibited affinities comparable celecoxib. Our computational predictions support suitability as drug candidates, indicating promise natural agents capable modulating signaling pathways.

Language: Английский

Citations

0