Biomedicines,
Journal Year:
2022,
Volume and Issue:
10(12), P. 3133 - 3133
Published: Dec. 5, 2022
We
previously
established
mouse
models
of
biliary
tract
cancer
(BTC)
based
on
the
injection
cells
with
epithelial
stem
cell
properties
derived
from
KRAS(G12V)-expressing
organoids
into
syngeneic
mice.
The
resulting
tumors
appeared
to
recapitulate
pathological
features
human
BTC.
Here
we
analyzed
images
hematoxylin
and
eosin
(H&E)
staining
for
both
tumor
tissue
cholangiocarcinoma
by
pixel-level
clustering
machine
learning.
A
pixel-clustering
model
that
was
via
training
revealed
homologies
structure
between
tumors,
suggesting
similarities
in
characteristics
independent
animal
species.
Analysis
samples
also
entropy
distribution
regions
higher
than
noncancer
regions,
pixels
thus
allowing
discrimination
these
two
types
regions.
Histograms
tended
be
broader
late-stage
cholangiocarcinoma.
These
analyses
indicate
our
BTC
are
appropriate
investigation
carcinogenesis
may
support
development
new
therapeutic
strategies.
In
addition,
is
highly
versatile
contribute
a
diagnostic
tool.
Sensors,
Journal Year:
2022,
Volume and Issue:
22(24), P. 9875 - 9875
Published: Dec. 15, 2022
Of
the
various
tumour
types,
colorectal
cancer
and
brain
tumours
are
still
considered
among
most
serious
deadly
diseases
in
world.
Therefore,
many
researchers
interested
improving
accuracy
reliability
of
diagnostic
medical
machine
learning
models.
In
computer-aided
diagnosis,
self-supervised
has
been
proven
to
be
an
effective
solution
when
dealing
with
datasets
insufficient
data
annotations.
However,
image
often
suffer
from
irregularities,
making
recognition
task
even
more
challenging.
The
class
decomposition
approach
provided
a
robust
such
challenging
problem
by
simplifying
boundaries
dataset.
this
paper,
we
propose
model,
called
XDecompo,
improve
transferability
features
pretext
downstream
task.
XDecompo
designed
based
on
affinity
propagation-based
effectively
encourage
explainable
component
highlight
important
pixels
that
contribute
classification
explain
effect
speciality
extracted
features.
We
also
explore
generalisability
handling
different
datasets,
as
histopathology
for
images.
quantitative
results
demonstrate
robustness
high
96.16%
94.30%
CRC
images,
respectively.
demonstrated
its
generalization
capability
achieved
(both
quantitatively
qualitatively)
compared
other
Moreover,
post
hoc
method
used
validate
feature
transferability,
demonstrating
highly
accurate
representations.
The
nodules
in
the
thyroid
region
can
be
cancerous
or
non-cancerous,
present
even
healthy
humans.
Early
diagnosis
of
cancer
is
helpful
for
prevention
and
treatment.
Diagnosing
using
traditional
approaches
a
hard-working
task
due
to
considerable
burden
on
healthcare
community.
In
this
paper,
we
analyzed
performance
AI
models
(Swin
Transformer,
Data
Efficient
Image
Mixer
Multi-layer
Perceptron)
extract
features
from
histopathological
ultrasound
images.
Locally
Linear
Embedding
(LLE)
used
reduce
dimensionality
feature
space.
These
transformed
are
utilized
training
five
classifiers
(Random
Forest
classifier,
Naive
Bayes,
Logistic
Regression,
Support
Vector
Classifier,
k-nearest
neighbors).
There
total
fifteen
possible
combination
tested
5-fold
cross-validation
technique,
three
metrics
calculated.
recently
proposed
TOPSIS
technique
benchmark
all
models,
based
scores,
rank
values
assigned.
distance
correlation-based
CRITIC
(CRiteria
Importance
Through
Intercriteria
Correlation)
employed
weight
calculation
different
criteria.
model
with
Swin
Transformer
as
extractor
Random
forest
classifier
outperformed
other
achieved
highest
score.
top-ranked
score
1.0000
an
accuracy
0.9335
0.8518
simple
deployed
resource-constrained
remote
edge
devices.
With
help
IoT
5G/6G
communication
technologies,
either
ensemble
created,
federated
learning
techniques
transfer
weights
order
train
cloud-based
global
model.
Biomedicines,
Journal Year:
2022,
Volume and Issue:
10(12), P. 3133 - 3133
Published: Dec. 5, 2022
We
previously
established
mouse
models
of
biliary
tract
cancer
(BTC)
based
on
the
injection
cells
with
epithelial
stem
cell
properties
derived
from
KRAS(G12V)-expressing
organoids
into
syngeneic
mice.
The
resulting
tumors
appeared
to
recapitulate
pathological
features
human
BTC.
Here
we
analyzed
images
hematoxylin
and
eosin
(H&E)
staining
for
both
tumor
tissue
cholangiocarcinoma
by
pixel-level
clustering
machine
learning.
A
pixel-clustering
model
that
was
via
training
revealed
homologies
structure
between
tumors,
suggesting
similarities
in
characteristics
independent
animal
species.
Analysis
samples
also
entropy
distribution
regions
higher
than
noncancer
regions,
pixels
thus
allowing
discrimination
these
two
types
regions.
Histograms
tended
be
broader
late-stage
cholangiocarcinoma.
These
analyses
indicate
our
BTC
are
appropriate
investigation
carcinogenesis
may
support
development
new
therapeutic
strategies.
In
addition,
is
highly
versatile
contribute
a
diagnostic
tool.