Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(10)
Published: Nov. 27, 2023
Abstract
Precision
medicine
requires
precise
regulation
of
drugs
in
terms
time,
space,
and
dosage.
Exogenous
control
systems,
such
as
electrical
responsiveness,
have
made
great
progress.
However,
wearable
or
implantable
controlled
drug
release
devices
still
face
major
challenges
due
to
limitations
including
limited
battery
life,
large
size,
fixed
power
supply.
To
overcome
these
limitations,
the
fabrication
autonomous
is
available
endure
extended
periods
without
reliance
on
external
sources.
As
a
promising
strategy,
nanogenerators
(NGs)
turn
body
mechanical
energy
into
electricity,
powering
long‐term
release.
In
this
review,
current
status
delivery
systems
(DDS)
briefly
outlined
importance
self‐driven
emphasized.
The
main
types
operational
mechanisms
various
are
introduced.
This
review
also
focuses
summarizing
latest
progress
self‐powered
based
(NG‐based
CDRs).
Additionally,
their
applications
field
introduced
detail.
Finally,
existing
future
trends
NG‐based
CDRs
discussed
from
perspectives
clinical
needs
practical
translation.
Biomaterials Science,
Journal Year:
2022,
Volume and Issue:
11(2), P. 356 - 379
Published: Nov. 15, 2022
Bacterial
infection
is
one
of
the
leading
causes
death
globally,
although
modern
medicine
has
made
considerable
strides
in
past
century.
As
traditional
antibiotics
are
suffering
from
emergence
drug
resistance,
new
antibacterial
strategies
great
interest.
Responsive
materials
appealing
alternatives
that
have
shown
potential
combating
resistant
bacteria
and
avoiding
side
effects
antibiotics.
In
this
review,
responsive
introduced
terms
stimulus
signals
including
intrinsic
(pH,
enzyme,
ROS,
etc.)
extrinsic
(light,
temperature,
magnetic
fields,
stimuli.
Their
biomedical
applications
therapeutics
medical
devices
then
discussed.
Finally,
author's
perspective
challenge
future
such
a
system
provided.
Materials & Design,
Journal Year:
2023,
Volume and Issue:
230, P. 111982 - 111982
Published: May 5, 2023
Bacterial
infection
is
a
series
of
pathological
changes
caused
by
bacteria
invading
the
host
and
interacting
with
body.
Nowadays,
bacterial
remains
major
public
health
issue
severe
threat
to
human
life
health.
Traditional
antibiotic
therapy
less
effective
against
biofilms
easily
causes
resistance,
which
has
urged
development
substitute
antibacterial
strategy.
Recently,
nanomaterials
have
attracted
much
attention.
However,
traditional
face
some
problems
insufficient
drug
concentration
at
infectious
sites
toxicity
extravasated
damage
healthy
tissues.
On
contrary,
based
on
advanced
on-demand
precise
strategies
reduce
biological
effectively
while
improving
germicidal
efficacy,
since
these
type
nanodrugs
higher
spatiotemporal
controllability.
Currently,
smart
stimuli-responsive
targeting
been
successfully
constructed
achieve
therapies.
This
review
focuses
mechanisms,
working
principles
antimicrobial
properties
diverse
nanoparticles
strategies.
Meanwhile,
strengths
inferiorities
different
discussed.
Finally,
this
concludes
our
opinions
future
directions
for
exploiting
next-generation
Biomaterials Research,
Journal Year:
2023,
Volume and Issue:
27(1)
Published: Feb. 9, 2023
Studies
have
reported
on
the
significance
of
copper
incorporated
nanomaterials
(CINMs)
in
cancer
theranostics
and
tissue
regeneration.
Given
their
unique
physicochemical
properties
tunable
nanostructures,
CINMs
are
used
photothermal
therapy
(PTT)
photothermal-derived
combination
therapies.
They
potential
to
overcome
challenges
unsatisfactory
efficacy
conventional
therapies
an
efficient
non-invasive
manner.
This
review
summarizes
recent
advances
CINMs-based
PTT
biomedicine.
First,
classification
structure
introduced.
tumors
guided
by
multiple
imaging
modalities
then
reviewed.
Various
representative
designs
bone,
skin
other
organs
presented.
Furthermore,
biosafety
is
discussed.
Finally,
this
analysis
delves
into
current
that
researchers
face
offers
optimistic
outlook
prospects
clinical
translational
research
field.
aims
at
elucidating
applications
derived
biomedicine
encourage
future
design
translation.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(10)
Published: Nov. 27, 2023
Abstract
Precision
medicine
requires
precise
regulation
of
drugs
in
terms
time,
space,
and
dosage.
Exogenous
control
systems,
such
as
electrical
responsiveness,
have
made
great
progress.
However,
wearable
or
implantable
controlled
drug
release
devices
still
face
major
challenges
due
to
limitations
including
limited
battery
life,
large
size,
fixed
power
supply.
To
overcome
these
limitations,
the
fabrication
autonomous
is
available
endure
extended
periods
without
reliance
on
external
sources.
As
a
promising
strategy,
nanogenerators
(NGs)
turn
body
mechanical
energy
into
electricity,
powering
long‐term
release.
In
this
review,
current
status
delivery
systems
(DDS)
briefly
outlined
importance
self‐driven
emphasized.
The
main
types
operational
mechanisms
various
are
introduced.
This
review
also
focuses
summarizing
latest
progress
self‐powered
based
(NG‐based
CDRs).
Additionally,
their
applications
field
introduced
detail.
Finally,
existing
future
trends
NG‐based
CDRs
discussed
from
perspectives
clinical
needs
practical
translation.
