Regenerative Biomaterials,
Journal Year:
2023,
Volume and Issue:
10
Published: Jan. 1, 2023
Cu-mediated
chemodynamic
therapy
(CDT)
has
attracted
prominent
attention
owing
to
its
advantages
of
pH
independence
and
high
efficiency
comparing
Fe-mediated
CDT,
while
the
application
Cu-based
CDT
agents
was
impeded
due
copper
consumption
caused
by
metabolism
loss
resultant
potential
toxicity.
Herein,
we
developed
a
new
copper-mediated
agent
with
extremely
low
Cu
usage
anchoring
on
cross-linked
lipoic
acid
nanoparticles
(Cu@cLAs).
After
endocytosis
into
tumor
cells,
Cu@cLAs
were
dissociated
LA
dihydrolipoic
(DHLA)
(reduced
form
LA)
released
Cu2+
Cu+
(oxidized
Cu2+),
two
redox
couples
recycled
each
other
in
cells
achieve
efficient
killing
cancer
delaying
metabolic
increasing
ROS
level
cells.
The
self-recycling
confirmed
sustained
Cu/DHLA
content
persistent
generation
process.
antitumor
study
based
MCF-7/R
nude
mice
gave
inhibitory
rate
up
77.9%
at
0.05
mg
kg-1,
first
dosage
reported
so
far
lower
than
that
normal
serum
(0.83
±
0.21
kg-1).
This
work
provides
not
only
promising
clinical
strategy
for
excessive
use
but
also
gives
clue
metal
mediated
disease
therapies
consumption.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(17), P. 17199 - 17216
Published: Aug. 25, 2023
The
clinical
applications
of
currently
used
photosensitizers
are
limited
by
high
costs,
inconvenient
preparation,
suboptimal
biodegradability,
and
a
lack
biological
activity.
Humic
acids
(HAs)
show
photothermal
activity
can
be
as
photosensitizer
for
therapy.
In
the
presence
various
functional
groups,
HAs
endowed
with
anti-inflammatory
antioxidant
activities.
solubility
is
dependent
on
pH
value,
which
soluble
in
neutral
to
alkaline
conditions
undergoes
conformational
change
coiled
compact
structure
acidic
conditions.
Additionally,
Cu2+
an
emerging
therapeutic
agent
cutaneous
wounds
chelated
form
complexes.
this
study,
we
explore
ability
modulate
inflammatory
response,
particularly
macrophage
polarization,
potential
underlying
mechanism.
We
fabricate
near-infrared
(NIR)/pH
dual-responsive
Cu-HAs
nanoparticle
(NP)-based
poly(vinyl
alcohol)
(PVA)
hydrogel
film
loaded
SEW2871
(SEW),
recruitment
agent,
treat
bacteria-infected
wounds.
results
that
could
promote
M2
polarization
dose-dependent
manner.
NPs
successfully
eradicated
bacterial
infection
through
NIR-induced
local
hyperthermia.
This
PVA@Cu-HAs
NPs@SEW
improves
tissue
regeneration
promoting
alleviating
oxidative
stress,
enhancing
angiogenesis,
facilitating
collagen
deposition.
These
findings
highlight
treatment
bacterially
infected
wound
healing.
Progress in Materials Science,
Journal Year:
2024,
Volume and Issue:
144, P. 101292 - 101292
Published: April 6, 2024
The
prevalence
of
multidrug-resistant
(MDR)
bacterial
infections
has
emerged
as
a
serious
threat
to
clinical
treatment
and
global
human
health,
become
one
the
most
important
challenges
in
therapy.
Hence,
there
is
an
urgent
need
develop
safe,
effective,
new
antibacterial
strategies
based
on
multifunctional
nanomaterials
for
accurate
detection
MDR
infections.
Chemodynamic
therapy
(CDT)
emerging
therapeutic
strategy
that
uses
Fenton/Fenton-like
metal-based
nanocatalysts
convert
hydrogen
peroxide
(H2O2)
into
hydroxyl
radicals
(OH)
destroy
Despite
enormous
potential
CDT,
single
CDT
limitations
such
low
catalytic
efficacy
insufficient
production
H2O2.
In
this
regard,
can
be
combined
with
other
strategies,
photothermal
(PTT),
which
effectively
enhanced
by
PTT
heating
effect.
Thus,
rational
combination
nanoplatform
been
demonstrated
highly
efficient
achieving
better
This
review
summarizes
discusses
latest
advances
photothermal-enhanced
(PT/CDT)
infection
theranostics
well
advantages,
challenges,
future
research
directions
applications,
will
inspire
development
PT/CDT
Abstract
Cuproptosis,
the
current
form
of
regulated
cell
death
characterized
by
copper
overload,
oligomerization
lipoacylated
proteins,
and
loss
Fe–S
cluster
has
been
proposed
to
function
closely
with
human
diseases,
including
cancer.
Since
its
first
identification
in
2022,
many
strategies
have
developed
induce
cuproptosis
for
cancer
therapy,
such
as
small‐molecule
drugs
nanomaterials.
Although
reviews
related
reported,
they
remain
at
a
basic
mechanism
level,
summary
covering
recent
progress
field
nanotechnologies
cuproptosis‐based
therapy
not
yet
presented.
Therefore,
it
is
time
fill
gap
shed
light
on
future
directions
application
this
promising
tool
fight
against
In
minireview,
we
expounded
action
emphasized
feasibility
triggering
therapy.
The
treatments
based
nanoparticle‐induced
was
then
described.
Finally,
challenges
development
emerging
are
also
discussed.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 31, 2024
Cuproptosis
is
a
recently
discovered
form
of
cell
death
that
mediated
by
copper
(Cu)
and
non-apoptotic
related
to
oligomerization
lipoylated
proteins
loss
Fe-S
protein
clusters.
Since
its
discovery,
cuproptosis
has
been
extensively
studied
researchers
for
mechanism
potential
applications
in
the
treatment
cancer.
Therefore,
this
article
reviews
specific
currently
studied,
as
well
principles
strategies
use
anti-cancer
treatment,
with
aim
providing
reference
cuproptosis-based
cancer
therapy.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(21), P. 14722 - 14741
Published: Jan. 1, 2024
Manganese-based
nanomaterials
have
seen
rapid
development
in
chemodynamic
therapy
and
T
1
-enhanced
MRI
over
the
past
five
years,
holding
promising
prospects
various
combined
applications.
ACS Biomaterials Science & Engineering,
Journal Year:
2024,
Volume and Issue:
10(6), P. 3673 - 3692
Published: May 8, 2024
Copper
(Cu)
and
Cu-based
nanomaterials
have
received
tremendous
attention
in
recent
years
because
of
their
unique
physicochemical
properties
good
biocompatibility
the
treatment
various
diseases,
especially
cancer.
To
date,
researchers
designed
fabricated
a
variety
integrated
nanocomplexes
with
distinctive
nanostructures
applied
them
cancer
therapy,
mainly
including
chemotherapy,
radiotherapy
(RT),
photothermal
therapy
(PTT),
chemodynamic
(CDT),
photodynamic
(PDT),
cuproptosis-mediated
etc.
Due
to
limited
effect
single
method,
development
composite
diagnostic
nanosystems
that
integrate
PTT,
CDT,
PDT,
other
treatments
is
great
significance
offers
potential
for
next
generation
anticancer
nanomedicines.
In
view
rapid
field
this
review
focuses
on
current
state
research
nanomaterials,
followed
by
discussion
combined
therapy.
Moreover,
challenges
future
prospects
clinical
translation
are
proposed
provide
some
insights
into
design
nanotherapeutic
platforms.
