Biosynthesis of Silver and Gold Nanoparticles and Their Efficacy Towards Antibacterial, Antibiofilm, Cytotoxicity, and Antioxidant Activities

Applied Biochemistry and Biotechnology, Journal Year: 2022, Volume and Issue: 195(2), P. 1158 - 1183

Published: Nov. 7, 2022

The World Health Organization (WHO) reports that the emergence of multidrug-resistant and slow advent novel more potent antitumor antimicrobial chemotherapeutics continue to be highest concern for human health. Additionally, stability, low solubility, negative effects existing drugs make them ineffective. Studies into alternative tactics tackle such tenacious diseases was sparked by anticancer antibacterial. Silver (Ag) gold (Au) nanoparticles (NPs) were created from Trichoderma saturnisporum, much productive fungal strain. Functional extracellular enzymes proteins carried out activities synthesis capping generated nano-metals. Characterization done on obtained Ag-NPs Au-NPs through UV-vis, FTIR, XRD, TEM, SEM. versus methicillin-sensitive Staphylococcus aureus (MSSA) methicillin-resistant (MRSA), Pseudomonas aeruginosa, Klebsiella pneumoniae, antibacterial assessed. In particular, effective against pathogenic bacteria than Au-NPs. Furthermore, antibiofilm study shown had activity Ag-NPs. Interestingly, applying DPPH procedure, these noble metallic NPs antioxidant activity, in which IC50 73.5 μg/mL 190.0 μg/mL, respectively. According cytotoxicity evaluation results, alteration cells as loss their typical shape, partial or complete monolayer, granulation, shrinking, cell rounding with normal Vero 693.68 661.24 Au-NPs, While cancer (Mcf7) 370.56 394.79 produced via green have potential employed medical industry beneficial nanocompounds.

Language: Английский

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Recent developments in the use of gold and silver nanoparticles in biomedicine

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2022, Volume and Issue: 14(5)

Published: July 1, 2022

Abstract Gold and silver nanoparticles (NPs) are widely used in the biomedical research both therapeutic sensing/diagnostics fronts. Both metals share some common optical properties with surface plasmon resonance being most exploited property therapeutics diagnostics. Au NPs exhibit excellent light‐to‐heat conversion efficiencies hence have found applications primarily precision oncology, while Ag antibacterial which can be harnessed biomaterials' design. constitute biosensing platforms owing to their plasmonic now routinely various platforms. The utilization of COVID‐19 pandemic was rapidly expanded mostly point‐of‐care extent therapeutics. In this review article, main physicochemical discussed selective examples from recent literature. This article is categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine for Oncologic Disease Diagnostic Tools Vitro Nanoparticle‐Based Sensing Nanotechnology Biology Nanoscale Systems

Language: Английский

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A comprehensive review on nanofluids: Synthesis, cutting-edge applications, and future prospects

International Journal of Thermofluids, Journal Year: 2024, Volume and Issue: 22, P. 100595 - 100595

Published: Feb. 9, 2024

Nanofluids, which are fluid suspensions containing nanoparticles, exhibit remarkable property enhancements even at low nanoparticle concentrations. Much of the research on nanofluids aims to understand their behavior for applications where heat transfer enhancement is crucial, spanning industrial, nuclear, transportation, electronics, biomedical, and food sectors. Notably, can act as smart fluids, allowing controlled modulation transfer. This paper presents an overview recent advances in nanofluid research, covering preparation techniques a wide range existing potential energy, mechanical engineering, biomedicine. Furthermore, highlights avenues future this field. In light findings, concludes that comprehensive hybrid model understanding thermophysical properties lacking. Further exploration additional unexplored aspects, particularly deemed essential. To capture entirety our study, graphical abstract provides representation.

Language: Английский

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The quest for nanoparticle-powered vaccines in cancer immunotherapy

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 14, 2024

Abstract Despite recent advancements in cancer treatment, this disease still poses a serious threat to public health. Vaccines play an important role preventing illness by preparing the body's adaptive and innate immune responses combat diseases. As our understanding of malignancies their connection system improves, there has been growing interest priming fight more effectively comprehensively. One promising approach involves utilizing nanoparticle systems for antigen delivery, which shown potentiate as vaccines and/or adjuvants. In review, we comprehensively summarized immunological mechanisms while focusing specifically on applications various types nanoparticles field immunotherapy. By exploring these breakthroughs, hope identify significant challenges obstacles making nanoparticle-based adjuvants feasible clinical application. This review serves assess breakthroughs vaccinations shed light prospects potential barriers. doing so, aim inspire future immunotherapies that harness nanotechnology deliver effective targeted treatments. Graphical abstract

Language: Английский

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α-Amino Acids as Reducing and Capping Agents in Gold Nanoparticles Synthesis Using the Turkevich Method

Langmuir, Journal Year: 2023, Volume and Issue: 39(25), P. 8646 - 8657

Published: June 14, 2023

Amino acid-capped gold nanoparticles (AuNPs) are a promising tool for various applications, including therapeutics and diagnostics. Most often, amino acids used to cap AuNPs synthesized with other reducing agents. However, only few studies have been dedicated using α-amino as capping agents in synthesis. Hence, there still several gaps understanding their role salts. Here, we 20 proteinogenic one non-proteinogenic acid analogy sodium citrate synthesizing the Turkevich method. Only four of twenty-one investigated not yielded nanoparticles. The shape, size distribution, stability, optical properties were characterized by scanning electron microscopy, differential centrifugal sedimentation, phase analysis light scattering technique, UV-vis spectroscopy. physicochemical characteristics varied reduction. We proposed that initial stage salts reduction most behave similarly different resulting from differences chemical structures significantly influence outcomes reactions.

Language: Английский

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Antimicrobial Peptides against Bacterial Pathogens: Innovative Delivery Nanosystems for Pharmaceutical Applications

Antibiotics, Journal Year: 2023, Volume and Issue: 12(1), P. 184 - 184

Published: Jan. 16, 2023

The introduction of antibiotics has revolutionized the treatment and prevention microbial infections. However, global spread pathogens resistant to available is a major concern. Recently, WHO updated priority list multidrug-resistant (MDR) species for which discovery new therapeutics urgently needed. In this scenario, antimicrobial peptides (AMPs) are potential alternative conventional antibiotics, as they show low risk developing resistance, thus preventing MDR bacterial there limitations challenges related clinical impact AMPs, well great scientific efforts find solutions aimed at improving their biological activity, in vivo stability, bioavailability by reducing eventual toxicity. To overcome some these issues, different types nanoparticles (NPs) have been developed AMP delivery over last decades. review, we provide an update on recent nanosystems applied with special attention pharmaceutical applications Among lipid nanomaterials, solid NPs nanocapsules employed enhance solubility protect from proteolytic degradation. addition, polymeric NPs, particularly nanogels, able help toxicity also increasing loading. boost activity instead, mesoporous silica or gold can be selected due easy surface functionalization. They used nanocarriers combinations, synergistically potentiating action against pathogens.

Language: Английский

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Nanostructures and nanoparticles as medical diagnostic imaging contrast agents: A review

Materials Today Chemistry, Journal Year: 2024, Volume and Issue: 40, P. 102233 - 102233

Published: Aug. 5, 2024

Language: Английский

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Nanotechnology in tissue engineering: expanding possibilities with nanoparticles

Nanotechnology, Journal Year: 2024, Volume and Issue: 35(39), P. 392002 - 392002

Published: June 28, 2024

Tissue engineering is a multidisciplinary field that merges engineering, material science, and medical biology in order to develop biological alternatives for repairing, replacing, maintaining, or boosting the functionality of tissues organs. The ultimate goal tissue create enhancing However, current landscape techniques presents several challenges, including lack suitable biomaterials, inadequate cell proliferation, limited methodologies replicating desired physiological structures, unstable insufficient production growth factors, which are essential facilitating communication appropriate cellular responses. Despite these there has been significant progress made recent years. Nanoparticles hold major role within realm nanotechnology due their unique qualities change with size. These particles, provide potential solutions issues met have helped propel its state prominence. substantial breakthroughs utilization nanoparticles over past two decades, full range addressing difficulties remains largely untapped. This fact advancements occurred relatively isolated pockets. In purpose this research conduct an in-depth investigation ways various types might be put use. addition this, it sheds light on challenges need conquered unlock maximum area.

Language: Английский

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Nanoscale Materials in Biomedical Applications of Sensors: Insights from a Comprehensive Landscape Analysis

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Since their inception in the early 1960s, use of nanoscale materials has progressed leaps and bounds, role diverse fields ranging from human health to energy is undeniable. Nanosensors are devices having dimensions designed detect, record, transmit signals provide valuable data information. In this review, we utilize CAS Content Collection, a vast repository scientific information extracted journals patent publications, identify emerging applications field. This involves understanding trends, such as growth certain topics over time, well establishing relationships between topics. Our analysis indicates that among various nanomorphologies explored nanosensors, nanoparticles, nanotubes, quantum dots tend lead. terms types chemical biological sensors account for nearly 80% publications. combination with bibliographic data, utilized our access Registry identified host across substance classes (polymers, small molecules, elements) associated nanosensor Finally, major application nanosensors appears be biomedical nature (cancer diagnosis/testing drug discovery, example). findings highlighted TrendScape map provides an overview research interest concepts We also snapshot commercial development briefly discuss currently under development. It hope review comprehensive field serves guide researchers/scientists.

Language: Английский

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Recent advances in nanomaterials and their mechanisms for infected wounds management

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101553 - 101553

Published: Feb. 5, 2025

Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient

Language: Английский

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