Advances in Wound Care,
Journal Year:
2024,
Volume and Issue:
13(11), P. 584 - 599
Published: June 18, 2024
Significance:
The
study
of
extracellular
vesicles
(EV),
especially
exosomes,
has
unlocked
new
avenues
in
understanding
cellular
communication
and
potential
therapeutic
avenues.
Recent
Advances:
Advancements
EV
research
have
shown
significant
contributions
from
the
International
Society
for
Extracellular
Vesicles
(ISEV),
establishing
methodological
standards.
evolution
MISEV
guidelines
2014
to
2023
reflects
enhanced
rigor
reproducibility.
launch
EV-TRACK
platform
promotes
uniformity
reproducibility
by
providing
a
centralized
repository
data
sharing
standardization
practices.
Furthermore,
databases
like
EVpedia
ExoCarta
facilitated
collaboration
within
scientific
community.
Concurrently,
exosome-based
therapies
emerged
as
forefront
area
regenerative
medicine
targeted
drug
delivery,
showcasing
exosomes
promoting
tissue
regeneration.
Critical
Issues:
Despite
advancements,
field
grapples
with
challenges
such
vesicular
heterogeneity,
isolation
complexity,
standardization.
These
issues
impact
clinical
applications.
inconsistency
exosomal
preparations
trials
poses
efficacy
safety.
Future
Directions:
review
outlines
critical
areas
future
research,
including
need
technological
innovation
characterization,
establishment
standardized
protocols,
deeper
exosome
biology.
also
highlights
reassess
guidelines,
develop
characterization
technologies,
establish
protocols
overcome
current
limitations.
Emphasis
is
placed
on
interdisciplinary
address
complexities
biology,
improve
trial
design,
ultimately
realize
exosome's
diagnostic
potential.
Continued
evaluation
rigorous
validation
are
essential
successful
integration.
Medicinal Research Reviews,
Journal Year:
2024,
Volume and Issue:
44(4), P. 1923 - 1966
Published: March 18, 2024
Over
the
past
few
decades,
there
has
been
a
notable
increase
in
global
burden
of
central
nervous
system
(CNS)
diseases.
Despite
advances
technology
and
therapeutic
options,
neurological
neurodegenerative
disorders
persist
as
significant
challenges
treatment
cure.
Recently,
remarkable
surge
interest
extracellular
vesicles
(EVs)
pivotal
mediators
intercellular
communication.
As
carriers
molecular
cargo,
EVs
demonstrate
ability
to
traverse
blood-brain
barrier,
enabling
bidirectional
result,
they
have
garnered
attention
potential
biomarkers
agents,
whether
their
natural
form
or
after
being
engineered
for
use
CNS.
This
review
article
aims
provide
comprehensive
introduction
EVs,
encompassing
various
aspects
such
diverse
isolation
methods,
characterization,
handling,
storage,
different
routes
EV
administration.
Additionally,
it
underscores
recent
applications
disorder
therapeutics.
By
exploring
unique
capabilities,
this
study
sheds
light
on
promising
future
clinical
research.
It
considers
inherent
limitations
these
emerging
while
incorporating
most
updates
field.
Advances in Wound Care,
Journal Year:
2024,
Volume and Issue:
13(11), P. 584 - 599
Published: June 18, 2024
Significance:
The
study
of
extracellular
vesicles
(EV),
especially
exosomes,
has
unlocked
new
avenues
in
understanding
cellular
communication
and
potential
therapeutic
avenues.
Recent
Advances:
Advancements
EV
research
have
shown
significant
contributions
from
the
International
Society
for
Extracellular
Vesicles
(ISEV),
establishing
methodological
standards.
evolution
MISEV
guidelines
2014
to
2023
reflects
enhanced
rigor
reproducibility.
launch
EV-TRACK
platform
promotes
uniformity
reproducibility
by
providing
a
centralized
repository
data
sharing
standardization
practices.
Furthermore,
databases
like
EVpedia
ExoCarta
facilitated
collaboration
within
scientific
community.
Concurrently,
exosome-based
therapies
emerged
as
forefront
area
regenerative
medicine
targeted
drug
delivery,
showcasing
exosomes
promoting
tissue
regeneration.
Critical
Issues:
Despite
advancements,
field
grapples
with
challenges
such
vesicular
heterogeneity,
isolation
complexity,
standardization.
These
issues
impact
clinical
applications.
inconsistency
exosomal
preparations
trials
poses
efficacy
safety.
Future
Directions:
review
outlines
critical
areas
future
research,
including
need
technological
innovation
characterization,
establishment
standardized
protocols,
deeper
exosome
biology.
also
highlights
reassess
guidelines,
develop
characterization
technologies,
establish
protocols
overcome
current
limitations.
Emphasis
is
placed
on
interdisciplinary
address
complexities
biology,
improve
trial
design,
ultimately
realize
exosome's
diagnostic
potential.
Continued
evaluation
rigorous
validation
are
essential
successful
integration.
