Editorial: Exploring the potential of nanobiomaterials in biomedical engineering: assessing biocompatibility, toxicity, and future prospects DOI Creative Commons
Narsimha Mamidi, Ebrahim Mostafavi, Murali M. Yallapu

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 23, 2024

The future of NBMs holds immense promise. By leveraging the capabilities nanotechnology and emulating intricate structures living tissues, offer exciting possibilities for diverse biomedical applications (Figure 1). These include targeted drug delivery systems to advanced implants improve human health. However, this progress hinges on a commitment rigorous safety assessments deep understanding how interact with biological systems. Through ongoing research development, can transform we diagnose, treat, prevent diseases, heralding new era personalized medicine. This special issue explores vital interactions between cells/tissues, focusing factors such as size, morphology, shape, surface chemistry NBM influence toxicity, biocompatibility, immunogenicity. elucidating these structure-function relationships, aim facilitate creation innovative tailored properties applications. includes three papers two review articles exploring recent advances in design, preparation, biocompatibility assessment NBMs.Guedri et al. investigated potential using alumina-ferrite (Al2O3-Fe3O4) hybrid nanoparticles thermal various fields, including biomedicine, electronics, mechanical engineering. 11 Their study focused interaction blood over 3D surface, considering like nonlinear radiation, stretching, velocity slippage, magnetic field. A mathematical model was developed nanofluid similarity rules. Numerical simulations were performed analyze behavior within blood. results showed that strong field effectively controlled motion nanoparticles, while stretching increased fluid movement. Thermal radiation found enhance both Al2O3-Fe3O4/blood Al2O3/blood. In iron sulfide-based nanozymes (ISNs), Shan highlighted growing interest due their stability, ease tunability. 12 They ISNs, widely studied nanomaterial enzyme-mimicking properties, outlining classification catalytic mechanisms followed by detailed examination use biosensors, tumor therapy, antibacterial other areas, underlining promise improving health.In another study, Puri explored green synthesis selenium (SeNPs) Terminalia arjuna bark extract. 13 abundant phenolics, flavonoids, tannins extract acted capping stabilizing agents, enabling formation stable, negatively charged, spherical TA-SeNPs. biogenic SeNPs exhibited excellent antioxidant, antibacterial, anticancer activities, making them promising candidates Notably, TA-SeNP-incorporated gel displayed desirable topical use. highlights safe sustainable development nanomedicines.Roma reviewed advancements graphene its derivatives dental 14 Highlighting unique activity, authors discuss methods, material characteristics, uses graphene-based materials. concludes challenges nanomaterials dentistry, aiming stimulate further research.A Dar effects nutrient sources rice growth yield. 15 Eight practices evaluated, recommended fertilizer dose (RFD), RFD silicon supplement, organic manure (FYM). treatment basal application Vigore (a commercial product) spray at panicle initiation (PI) stage (N3) resulted highest plant height, number tillers, density, weight, grain approach yielded 22-25% more than FYM or alone. suggests timing significantly yield.Altogether, presented highlight significant nanobiomaterials. We extend our sincere gratitude all contributing sharing valuable insights solutions. Special thanks go editors reviewers whose expertise enhanced quality papers. Despite advancements, remain. Future success deeper Continued hold revolutionize disease diagnosis, treatment, prevention, paving way trust will be informative inspiring, particularly young scholars eager contribute research.

Language: Английский

Bio-Inspired Nanomaterials for Micro/Nanodevices: A New Era in Biomedical Applications DOI Creative Commons
Mohammad Harun‐Ur‐Rashid, Israt Jahan, Tahmina Foyez

et al.

Micromachines, Journal Year: 2023, Volume and Issue: 14(9), P. 1786 - 1786

Published: Sept. 18, 2023

Exploring bio-inspired nanomaterials (BINMs) and incorporating them into micro/nanodevices represent a significant development in biomedical applications. Nanomaterials, engineered to imitate biological structures processes, exhibit distinctive attributes such as exceptional biocompatibility, multifunctionality, unparalleled versatility. The utilization of BINMs demonstrates potential diverse domains micro/nanodevices, encompassing biosensors, targeted drug delivery systems, advanced tissue engineering constructs. This article thoroughly examines the various BINMs, including those originating from proteins, DNA, biomimetic polymers. Significant attention is directed toward these entities subsequent ramifications that arise. review explores biomimicry’s structure–function correlations. Synthesis mosaics include bioprocesses, biomolecules, natural structures. These nanomaterials’ interfaces use functionalization geometric adaptations, transforming delivery, nanobiosensing, organ-on-chip cancer-on-chip models, wound healing dressing mats, antimicrobial surfaces. It provides an in-depth analysis existing challenges proposes prospective strategies improve efficiency, performance, reliability devices. Furthermore, this study offers forward-thinking viewpoint highlighting avenues for future exploration advancement. objective effectively utilize maximize application progression thereby propelling rapidly developing field its promising future.

Language: Английский

Citations

58
Advancements in Functional Nanomaterials Inspired by Viral Particles DOI

Xianxun Sun,

Yindong Lian,

Tao Tian

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: July 26, 2024

Abstract Virus‐like particles (VLPs) are nanostructures composed of one or more structural proteins, exhibiting stable and symmetrical structures. Their precise compositions dimensions provide versatile opportunities for modifications, enhancing their functionality. Consequently, VLP‐based nanomaterials have gained widespread adoption across diverse domains. This review focuses on three key aspects: the mechanisms viral capsid protein self‐assembly into VLPs, design methods constructing multifunctional strategies synthesizing multidimensional using VLPs. It provides a comprehensive overview advancements in virus‐inspired functional nanomaterials, encompassing VLP assembly, functionalization, synthesis nanomaterials. Additionally, this explores future directions, opportunities, challenges field aiming to shed light potential prospects exciting area research.

Language: Английский

Citations

4
DNA Nanostructures for Rational Regulation of Cellular Organelles DOI Creative Commons

Petra Elblová,

Judita Anthi, Minghui Liu

et al.

JACS Au, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

DNA nanotechnology has revolutionized materials science and biomedicine by enabling precise manipulation of matter at the nanoscale. nanostructures (DNs) in particular represent a promising frontier for targeted therapeutics. Engineered DNs offer unprecedented molecular programmability, biocompatibility, structural versatility, making them ideal candidates advanced drug delivery, organelle regulation, cellular function modulation. This Perspective explores emerging role modulating behavior through organelle-targeted interventions. We highlight current advances nuclear, mitochondrial, lysosomal targeting, showcasing applications ranging from gene delivery to cancer For instance, have enabled precision mitochondrial disruption cells, pH modulation enhance silencing, nuclear gene-editing templates. While hold immense promise advancing nanomedicine, outstanding challenges include optimizing biological interactions addressing safety concerns. highlights potential rational control organelles, which could lead novel therapeutic strategies advancement nanomedicines future.

Language: Английский

Citations

0
Recent advances in biomimetic nanodelivery systems for cancer Immunotherapy DOI Creative Commons
Jiawei Yang, Xueqi Li, Tongyu Li

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101726 - 101726

Published: April 1, 2025

Language: Английский

Citations

0
From innovation to application: safety concerns in nanomaterial implant coatings DOI Creative Commons

Eileen Tabrizi,

Bingyun Li

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 4

Published: March 19, 2025

Language: Английский

Citations

0
Targeted and intelligent nano-drug delivery systems for colorectal cancer treatment DOI Creative Commons

Meihong Chai,

Shihua Wang, Yuxin Chen

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: April 25, 2025

Colorectal cancer (CRC) remains a highly heterogeneous malignancy with significant morbidity and mortality worldwide. Despite advancements in surgery, chemotherapy, immunotherapy, targeted therapy, treatment efficacy is often hampered by drug resistance systemic toxicity. In recent years, nano-drug delivery systems (NDDS) have emerged as promising strategy to enhance therapeutic precision, reduce adverse effects, overcome CRC treatment. This review discusses the NDDS for treatment, focusing on optimization of oral systems, development tumor-specific targeting strategies, design intelligent responsive tumor microenvironment (TME). Furthermore, we summarize current challenges translation explore future research directions enhancing their clinical feasibility impact.

Language: Английский

Citations

0
Revealing chemistry-structure-function relationships in shark vertebrae across length scales DOI

Dawn Raja Somu,

Malena Fuentes,

Lihua Lou

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

1
Electrodynamic therapy: Novel nanodynamic strategy for anticancer and anti-infection therapy DOI
Wenxin Liu, Ning Wu,

Jinze Song

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 494, P. 152882 - 152882

Published: June 5, 2024

Language: Английский

Citations

1
Advancements in Designing Smart and Intelligent Nanocoatings DOI
Mukhtar Iderawumi Abdulraheem, Abiodun Yusuff Moshood, Yongqi Chen

et al.

Advances in chemical and materials engineering book series, Journal Year: 2024, Volume and Issue: unknown, P. 57 - 87

Published: Feb. 27, 2024

Smart and intelligent nanocoatings have emerged as crucial components in various industries, offering enhanced functionalities improved performance. This chapter explores the recent advancements studying smart nanocoatings, encompassing their design, synthesis, characterization, applications. The aims to provide a comprehensive understanding of current state-of-the-art this field highlight potential for future development research. concluded that developing has significantly industries' performance, durability, safety. However, research focuses on reducing costs, scaling up production, creating more advanced systems with existing technologies, such sensors actuators.

Language: Английский

Citations

0
Biosustainable Hybrid Nanoplatforms as Photoacoustic Agents DOI
Giulio Pota, Paolo Armanetti, Brigida Silvestri

et al.

Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: 24(7)

Published: March 21, 2024

The development of biosafe theranostic nanoplatforms has attracted great attention due to their multifunctional behavior, reduced potential toxicity, and improved long-term safety. When considering photoacoustic contrast agents photothermal conversion tools, melanin constructs like are highly appealing ability absorb optical energy convert it into heat. Following a sustainable approach, in this study, silver-melanin like-silica synthesized exploiting different bio-available inexpensive phenolic acids as melanogenic precursors exploring role tuning the final systems architecture. UV-Vis combined with X-Ray Diffraction investigation proves metallic silver formation, while Transmission Electron Microscopy analysis reveals that morphologies can be obtained by properly selecting precursors. By looking at characterization results, tentative formation mechanism is proposed explain how precursors' redox behavior may affect nanoplatforms' structure. antibacterial activity experiments showed all have strong inhibitory effect on Escherichia coli, even low concentrations. Furthermore, very sensitive Photoacoustic Imaging capabilities significant under laser irradiation exhibited. Finally, marked influence phenol nature system architecture revealed resulting both biological features systems. These melanin-based hybrid exhibit excellent triggerable for various biomedical applications.

Language: Английский

Citations

0