Integration of Functional Materials in Photonic and Optoelectronic Technologies for Advanced Medical Diagnostics

Biosensors, Journal Year: 2025, Volume and Issue: 15(1), P. 38 - 38

Published: Jan. 10, 2025

Integrating functional materials with photonic and optoelectronic technologies has revolutionized medical diagnostics, enhancing imaging sensing capabilities. This review provides a comprehensive overview of recent innovations in materials, such as quantum dots, perovskites, plasmonic nanomaterials, organic semiconductors, which have been instrumental the development diagnostic devices characterized by high sensitivity, specificity, resolution. Their unique optical properties enable real-time monitoring biological processes, advancing early disease detection personalized treatment. However, challenges material stability, reproducibility, scalability, environmental sustainability remain critical barriers to their clinical translation. Breakthroughs green synthesis, continuous flow production, advanced surface engineering are addressing these limitations, paving way for next-generation tools. article highlights transformative potential interdisciplinary research overcoming emphasizes importance sustainable scalable strategies harnessing diagnostics. The ultimate goal is inspire further innovation field, enabling creation practical, cost-effective, environmentally friendly solutions.

Language: Английский

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Optimizing CRISPR/Cas9 precision: Mitigating off-target effects for safe integration with photodynamic and stem cell therapies in cancer treatment

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117516 - 117516

Published: Sept. 26, 2024

Language: Английский

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Nanoparticles in Drug Delivery Systems: Challenges, Innovations, And Surface Modification for Targeted Therapeutics

Indus journal of bioscience research., Journal Year: 2025, Volume and Issue: 3(1), P. 325 - 336

Published: Jan. 16, 2025

Nanoparticles have become a transforming platform in drug delivery systems. Their remarkable advancement over traditional methods builds upon an improvement bioavailability, stability, and controlled of therapeutic agents. Here, we discuss the broad spectrum potential nanoparticle-based Challenges, innovations, surface modification strategies that affect their clinical translation are discussed. Notwithstanding they present, challenges including biocompatibility, toxicity, targeting efficiency persist restricting extensive utilization. The review emphasizes recent advancements, stimuli-responsive nanoparticles, which provide release reaction to environmental triggers, as well targeted delivery, facilitates selective accumulation agents at designated sites disease. Besides, techniques, such PEGylation, ligand conjugation, charge modulation, been highly promising improving stability reducing immunogenicity, enhancing cellular uptake. future systems based on nanoparticles will address these through new innovations nanoparticle design effect more effective treatments. While research advances, likely bring revolution personalized medicine, tailoring medical therapy for different diseases with minimal side effects better patient outcomes.

Language: Английский

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The photodynamic anti-cancer and anti-bacterial behaviour of meso-substituted trans-A2B2 porphyrin conjugated silica‑gold nanoparticles

Inorganica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 122584 - 122584

Published: Feb. 1, 2025

Language: Английский

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CDC25A inhibition sensitizes melanoma cells to doxorubicin and NK cell therapy

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 11, 2025

Abstract Cell division cycle 25 (CDC25) phosphatases serve as crucial regulators of cell phase transitions and essential components the checkpoint machinery involved in DNA damage response. Emerging evidence indicates oncogenic potential CDC25 family members across various cancers. However, comprehensive insights into expression pattern function diverse cancers remain unexplored. In our study, we investigated using multiple databases, including gene levels, molecular signatures, diagnosis value, prognostic value pan-cancer. Furthermore, focused on melanoma systematically explored CDC25A its clinical correlations. As a result, is significantly abnormal most cancers, correlating with poorer prognosis. are differently regulated by methylation genetic alterations addition, plays critical role malignant progression melanoma. Functional investigation reveals that inhibition suppresses proliferation cells sensitizes to chemotherapy NK therapy. conclusion, study suggests may significant biomarker for prognosis promising therapeutic target

Language: Английский

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Breaking the Resistance: Photodynamic Therapy in Cancer Stem Cell-Driven Tumorigenesis

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 559 - 559

Published: April 24, 2025

Cancer stem cells (CSCs) are essential for the growth of malignancies because they encourage resistance to cancer therapy and make metastasis relapse easier. To effectively tackle obstacles presented by CSCs, novel therapeutic approaches required. Photodynamic (PDT) is a promising treatment option cells, which uses light-sensitive medications that activated light wavelengths. This review investigates use PDT overcome driven CSCs have innate mechanisms. works causing tumor accumulate photosensitizers (PSs) selectively. The reactive oxygen species (ROS), kill released these PSs when stimulated light. According recent developments in PDT, its efficacy may go beyond traditional providing viable remedy shown CSCs. Researchers want improve targeted elimination selective targeting combining with new customized delivery systems. Studies emphasize how affects as well bulk cells. studies, not only limits CSC but also modifies their microenvironment, lowers possibility recovery. Additionally, studies being conducted on utilization immunotherapeutic techniques inherent In conclusion, strategy treating carcinogenesis By applying most advancements technologies recognizing it interacts this has potential surpass mechanisms future patients. Clinical preclinical highlight CSC-targeted current limitations. Future efforts should focus clinical validation, optimizing PS use, developing effective combination strategies target

Language: Английский

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Combining Photodynamic Therapy and Targeted Drug Delivery Systems: Enhancing Mitochondrial Toxicity for Improved Cancer Outcomes

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10796 - 10796

Published: Oct. 8, 2024

Cancer treatment continues to be a substantial problem due tumor complexities and persistence, demanding novel therapeutic techniques. This review investigates the synergistic potential of combining photodynamic therapy (PDT) tailored medication delivery technologies increase mitochondrial toxicity improve cancer outcomes. PDT induces selective cellular damage death by activating photosensitizers (PS) with certain wavelengths light. However, PDT's efficacy can hampered issues such as poor light penetration lack selectivity. To overcome these challenges, targeted drug systems have emerged promising technique for precisely delivering medicines cells while avoiding off-target effects. We investigate how targeting damage, which is critical causing cell death. The combination method seeks capitalize on advantages both modalities: activation specific delivery. current preclinical clinical evidence supporting this therapy, focusing case studies experimental models. also addresses safety, distribution efficiency, resistance mechanisms, costs. prospects further research include advances in agents technology, focus personalized treatment. In conclusion, provides frontier ability limits open way more effective, treatments.

Language: Английский

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Vaginal Ovule Loaded with Bismuth Lipophilic Nanoparticles and Cetylpyridinium Chloride Inhibits Human Cervical Carcinoma and Candida albicans Growth

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(8), P. 206 - 206

Published: July 25, 2024

Bismuth lipophilic nanoparticles (BisBAL NPs) and cetylpyridinium chloride (CPC) are antineoplastic antimicrobial in vitro. As a next pre-clinical step, clinically viable dosage form for vaginal application was developed. Compendial pharmacopeial tests (mass uniformity, disintegration, compressive mechanics) inductively coupled plasma optical emission spectroscopy were conducted on in-house developed glycerinated gelatin (60:15

Language: Английский

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Advancing Photodynamic Therapy with Nano-Conjugated Hypocrellin: Mechanisms and Clinical Applications

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 11023 - 11038

Published: Oct. 31, 2024

Hypocrellin-based photodynamic therapy (PDT) is developing as a viable cancer therapeutic option, especially when enhanced by nanoconjugation. This review investigates the methods which nano-conjugated hypocrellin enhances efficacy and precision targeting cells. These nanoconjugates encapsulate or covalently bind photosensitizers (PSs), allowing them to accumulate preferentially in malignancies. When activated light, produce singlet oxygen other reactive species (ROS), resulting oxidative stress that selectively destroys cells while protecting healthy tissues. We look at how they can be used treat variety of cancers. Clinical preclinical studies show have advantages such increased water solubility, improved tumor penetration, longer circulation times, tailored delivery, all contribute fewer off-target effects overall toxicity. Ongoing research focuses on improving these for better targeting, drug release kinetics, overcoming biological obstacles. Furthermore, incorporation technologies stimuli-responsive nanocarriers combination therapies opens exciting opportunities enhancing hypocrellin-based PDT. In conclusion, nanotechnology constitutes significant approach treatment, increasing safety Future will seek create conjugates including hypocrellin, herceptin, gold nanoparticles induce apoptosis human breast vitro, opening possibilities applications.

Language: Английский

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Activity of Hydrophilic, Biocompatible, Fluorescent, Organic Nanoparticles Functionalized with Purpurin-18 in Photodynamic Therapy for Colorectal Cancer

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(19), P. 1557 - 1557

Published: Sept. 26, 2024

Photodynamic therapy (PDT) is a clinically approved, non-invasive currently used for several solid tumors, triggering cell death through the generation of reactive oxygen species (ROS). However, hydrophobic nature most photosensitizers used, such as chlorins, limits overall effectiveness PDT. To address this limitation, use nanocarriers seems to be powerful approach. From perspective, we have recently developed water-soluble and biocompatible, fluorescent, organic nanoparticles (FONPs) functionalized with purpurin-18 its derivative, chlorin p6 (Cp6), new PDT agents. In study, aimed investigate induced mechanism mediated by these after photoactivation. Our results show strong phototoxic effects FONPs[Cp6], intracellular ROS generation, subcellular localization in HCT116 HT-29 human colorectal cancer (CRC) cells. Additionally, proved that, post-PDT, FONPs[Cp6] induce apoptosis via intrinsic mitochondrial pathway, shown significant upregulation Bax/Bcl-2 ratio, activation caspases 9, 3, 7, leading poly-ADP-ribose polymerase (PARP-1) cleavage, DNA fragmentation. work demonstrates photodynamic activity nanoparticles, making them promising candidates treatment CRC.

Language: Английский

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