Bioactive Polymeric Scaffolds: Multivalent Functionalization by Thermal Azide–Alkyne Cycloaddition with Alkynyl Dicarbamates

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Multivalency enables interactions with higher affinities and specificities than monovalent interactions. The strategy exploited by nature to modulate biorecognition has inspired the design of multivalent conjugates therapeutic properties. However, chemical functionalization often requires coupling agents, additives, or metal catalysts that complicate isolation purification. Herein, azide–alkyne cycloaddition (AAC) alkynyl dicarbamates (Alk-R) is presented as a flexible, reliable, atom-economical, user-friendly for polymeric scaffolds. Alk-R functionalized biologically relevant ligands have been prepared used AAC azide-bearing dendrimers block copolymers. resulting polymers double multivalency reveal platform development bioinspired functional systems promising applications in drug delivery: copolymer micelles multifunctional nanocarriers synergistically integrated probes-ligands-drugs. extension this other scaffolds expected open up wide range diagnostic opportunities.

Language: Английский

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Unveiling Hierarchical Self‐Assembly of Triazolylferrocenyl Dendrimers: Producing Non‐Traditional Intrinsically Green Fluorescent Vesosomes for Nanotheranostics

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(32)

Published: Sept. 15, 2024

Abstract Dendrimers and supramolecular chemistry continue to fascinate researchers due the endless unrevealed potential of their combination. This study investigates self‐assembly process a series hydrophobic triazolylferrocenyl dendrimers in aqueous medium. Deep investigation through NMR spectroscopy, absorption UV–vis spectroscopy along with theoretical simulations demonstrates that ferrocenyl moieties interact intramolecularly intermolecularly driving process. Data obtained by DLS, NTA, SEM, TEM, EF‐TEM demonstrate these dendrimers, water, spontaneously self‐assemble hierarchical The first into uniform nanovesicles, which turn larger vesosomes. resulting vesosomes emit green non‐traditional intrinsic fluorescence, is property emerged from self‐assembled architectures. are efficiently uptaken cancer cells induce significant cytotoxic activity against cell line MCF‐7, up submicromolar concentration. Positive dendritic effects identified fluorescence intensity vesosomes, follow trend G0‐9Fc < G1‐27Fc G2‐81Fc. work showcases remarkable combining two dynamic fields chemistry, resulted fluorescent capable performing dual role imaging killing, applications nanotheranostics.

Language: Английский

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Recent advances in PAMAM mediated nano-vehicles for targeted drug delivery in Cancer Therapy

Journal of drug targeting, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 21

Published: Nov. 12, 2024

3-D multi-faceted, nano-globular PAMAM dendritic skeleton is a highly significant polymer that offers applications in biomedical, industrial, environmental and agricultural fields. This mainly due to its enhanced properties, including adjustable surface functionalities, biocompatibility, non-toxicity, high uniformity reduced cytotoxicity, as well numerous internal cavities. trait inspires further exploration advancements tailoring approaches. The implementation of deliberate strategic modifications the morphological characteristics crucial through chemical biological interventions, addition therapeutic advancements. Thus, production peripheral groups remains prominent advanced technique molecular fabrication, aimed at boosting potential conjugates. Currently, there exist dendritic-hybrid materials, despite widespread use PAMAM-conjugated frameworks drug delivery systems, which are regarded for their efficacy enhancing potency incorporation functions. paper provides comprehensive review recent progress design assembly various components conjugates, focusing on unique formulations. encompasses synthetic methodologies, thorough evaluation applicability, an analysis functions context Drug Delivery Systems (DDS) current period.

Language: Английский

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How Dendrimers Impact Fibrin Clot Formation, Structure, and Properties

ACS Omega, Journal Year: 2024, Volume and Issue: 9(52), P. 51306 - 51319

Published: Dec. 18, 2024

Polyamidoamine (PAMAM) dendrimers, with their unique structural versatility and tunable surface functionalities, have emerged as promising nanomaterials for a wide range of biomedical applications. However, in vivo use raises concerns, unintended interactions between dendrimers blood components could disrupt the delicate hemostatic balance lead to serious complications like bleeding or thrombosis. In this study, we explored impact low-generation PAMAM on kinetics fibrin clot formation, along influence structure, properties, resistance lysis resulting clots. For purpose, employed multilevel characterization approach using purified fibrinogen, human plasma, whole assess effects four dendrimer types: G2-NH2, G4-NH2, G3.5-COOH, G4-OH. Among main findings, both G2-NH2 G4-NH2 significantly impaired thrombin generation delayed also promoting aggregation, increasing permeability, accelerating lysis. When present at high concentrations, G4-OH affected critical clotting parameters, delaying prolonging time. Notably, prolongation time by was evident plasma blood. Interestingly, G3.5-COOH showed potential safer option since it induced minimal alterations across most tested metrics. These results will be important guiding rational design identifying safe concentrations future clinical

Language: Английский

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Hybrid nano-stimulator for specific amplification of oxidative stress and precise tumor treatment

Journal of drug targeting, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: June 4, 2024

The use of reactive oxygen species (ROS) to target cancer cells has become a hot topic in tumor therapy.

Language: Английский

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