The Photomodification Method Allows for Determining the Composition of the Full and Soft Protein Corona on the Lipid Surface of Composite Nanoparticles DOI Creative Commons
Anna V. Epanchintseva, Svetlana V. Baranova, Julia E. Poletaeva

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(23), P. 1976 - 1976

Published: Dec. 9, 2024

A protein corona (PC) is formed and maintained on the surface of any nanoparticle (NP) introduced into biological media. The full PC by a hard soft corona, latter determines nature interaction NPs with cells body's liquids. Nanomedicines are becoming increasingly important in modern health services, making information about composition PCs critically for "managing" behavior nano-objects body. Currently, only few studies report complete PC, since isolation preservation NP extremely difficult. Recently, we proposed first time photomodification method to fix lipid composite NPs, along their purification. In this work, using tandem mass spectrometry, successively determined also identified corona. To test method, changed medium whose proteins found changes its composition.

Language: Английский

The Photomodification Method Allows for Determining the Composition of the Full and Soft Protein Corona on the Lipid Surface of Composite Nanoparticles DOI Creative Commons
Anna V. Epanchintseva, Svetlana V. Baranova, Julia E. Poletaeva

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(23), P. 1976 - 1976

Published: Dec. 9, 2024

A protein corona (PC) is formed and maintained on the surface of any nanoparticle (NP) introduced into biological media. The full PC by a hard soft corona, latter determines nature interaction NPs with cells body's liquids. Nanomedicines are becoming increasingly important in modern health services, making information about composition PCs critically for "managing" behavior nano-objects body. Currently, only few studies report complete PC, since isolation preservation NP extremely difficult. Recently, we proposed first time photomodification method to fix lipid composite NPs, along their purification. In this work, using tandem mass spectrometry, successively determined also identified corona. To test method, changed medium whose proteins found changes its composition.

Language: Английский

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